Advances in Metabolomics: A Comprehensive Review of Type 2 Diabetes and Cardiovascular Disease Interactions DOI Open Access
Lilian Fernandes Silva, Markku Laakso

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3572 - 3572

Published: April 10, 2025

Type 2 diabetes (T2D) and cardiovascular diseases (CVDs) are major public health challenges worldwide. Metabolomics, the exhaustive assessment of metabolites in biological systems, offers important insights regarding metabolic disturbances related to these disorders. Recent advances toward integration metabolomics into clinical practice facilitate discovery novel biomarkers that can improve diagnosis, prognosis, treatment T2D CVDs discussed this review. Metabolomics potential characterize key alterations associated with disease pathophysiology treatment. is a heterogeneous develops through diverse pathophysiological processes molecular mechanisms; therefore, disease-causing pathways not completely understood. studies have identified several robust clusters variants representing biologically meaningful, distinct pathways, such as beta cell proinsulin cluster pancreatic insulin secretion, obesity, lipodystrophy, liver/lipid cluster, glycemia, blood pressure, syndrome different causing resistance. Regarding CVDs, recent allowed metabolomic profile delineate contribute atherosclerosis heart failure, well development targeted therapy. This review also covers role integrated genomics other omics platforms better understand mechanisms, along transition precision medicine. further investigates use multi-metabolite modeling enhance risk prediction models for predicting first occurrence adverse events among individuals T2D, highlighting value approaches optimizing preventive therapeutic used practice.

Language: Английский

Key factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks. DOI Creative Commons
Michaël Maes, Ketsupar Jirakran, Laura de Oliveira Semeão

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Background Major depressive disorder (MDD) is associated with neuro-immune – metabolic oxidative (NIMETOX) pathways. Aims To examine the connections among NIMETOX pathways in outpatient MDD (OMDD) and without syndrome (MetS); to determine prevalence of aberrations a cohort OMDD patients. Methods We included 67 healthy controls 66 patients we assessed various Results successfully identified subgroup individuals pathways, including diminished lecithin-cholesterol acyltransferase (LCAT), paraoxonase 1 (PON1) activity, reverse cholesterol transport (RCT) activities, elevated atherogenicity, differentially expressed immune networks, advanced oxidation protein products (AOPP). A large part variance (around 44%) atherogenicity indices was AOPP, fasting blood glucose (FBG), PON1 activation. LCAT activity positively correlated negatively FBG, AOPP RCT related R/R 192 genotype FBG larger overall severity (50.4%), suicidal behaviors (27.7%), neuroticism (42.1%) adverse childhood experiences immune-related neurotoxicity, insulin, inversely neuroprotection. Conclusions Many (78.8%) show The features OMDD, illness, neuroticism, behaviors, are caused by intertwined that may exert additional effects depending on whether MetS present or not.

Language: Английский

Citations

0
Differential impacts of high-intensity interval training and moderate-intensity continuous training on obesity-induced behavioral and biochemical dysregulation in male mice DOI

Hossein Nazari,

Ayoob Sabaghi,

Ershad Nedaei

et al.

Sport Sciences for Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0
Advances in Metabolomics: A Comprehensive Review of Type 2 Diabetes and Cardiovascular Disease Interactions DOI Open Access
Lilian Fernandes Silva, Markku Laakso

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3572 - 3572

Published: April 10, 2025

Type 2 diabetes (T2D) and cardiovascular diseases (CVDs) are major public health challenges worldwide. Metabolomics, the exhaustive assessment of metabolites in biological systems, offers important insights regarding metabolic disturbances related to these disorders. Recent advances toward integration metabolomics into clinical practice facilitate discovery novel biomarkers that can improve diagnosis, prognosis, treatment T2D CVDs discussed this review. Metabolomics potential characterize key alterations associated with disease pathophysiology treatment. is a heterogeneous develops through diverse pathophysiological processes molecular mechanisms; therefore, disease-causing pathways not completely understood. studies have identified several robust clusters variants representing biologically meaningful, distinct pathways, such as beta cell proinsulin cluster pancreatic insulin secretion, obesity, lipodystrophy, liver/lipid cluster, glycemia, blood pressure, syndrome different causing resistance. Regarding CVDs, recent allowed metabolomic profile delineate contribute atherosclerosis heart failure, well development targeted therapy. This review also covers role integrated genomics other omics platforms better understand mechanisms, along transition precision medicine. further investigates use multi-metabolite modeling enhance risk prediction models for predicting first occurrence adverse events among individuals T2D, highlighting value approaches optimizing preventive therapeutic used practice.

Language: Английский

Citations

0