ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
This patent application presents the discovery and characterization of a novel series triazole-substituted imidazo[1,2-a]pyrimidine compounds as selective cGAS inhibitors. These effectively suppress enzymatic activity modulate downstream STING signaling, demonstrating potential for treating autoimmune inflammatory diseases driven by aberrant cytosolic DNA sensing.
Language: Английский
ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
This patent application presents the discovery and characterization of a novel series triazole-substituted imidazo[1,2-a]pyrimidine compounds as selective cGAS inhibitors. These effectively suppress enzymatic activity modulate downstream STING signaling, demonstrating potential for treating autoimmune inflammatory diseases driven by aberrant cytosolic DNA sensing.
Language: Английский
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