Phenotyping the Chemical Communications of the Intestinal Microbiota and the Host: Secondary Bile Acids as Postbiotics DOI Creative Commons

Ginevra Urbani,

Elena Rondini,

Eleonora Distrutti

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 595 - 595

Published: April 15, 2025

The current definition of a postbiotic is “preparation inanimate microorganisms and/or their components that confers health benefit on the host”. Postbiotics can be mainly classified as metabolites, derived from intestinal bacterial fermentation, or structural components, intrinsic constituents microbial cell. Secondary bile acids deoxycholic acid (DCA) and lithocholic (LCA) are metabolites generated by enzymatic modifications primary enzymes. function receptor ligands modulating activity family bile-acid-regulated receptors (BARRs), including GPBAR1, Vitamin D (VDR) RORγT expressed various cell types within entire human body. integrate postbiotics, exerting potential beneficial effects given ability to regulate multiple biological processes such glucose metabolism, energy expenditure inflammation/immunity. Although there evidence might harmful intestine, most this does not account for dysbiosis. This review examines novel conceptual framework secondary postbiotics how these mediators participate in maintaining host health.

Language: Английский

Phenotyping the Chemical Communications of the Intestinal Microbiota and the Host: Secondary Bile Acids as Postbiotics DOI Creative Commons

Ginevra Urbani,

Elena Rondini,

Eleonora Distrutti

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 595 - 595

Published: April 15, 2025

The current definition of a postbiotic is “preparation inanimate microorganisms and/or their components that confers health benefit on the host”. Postbiotics can be mainly classified as metabolites, derived from intestinal bacterial fermentation, or structural components, intrinsic constituents microbial cell. Secondary bile acids deoxycholic acid (DCA) and lithocholic (LCA) are metabolites generated by enzymatic modifications primary enzymes. function receptor ligands modulating activity family bile-acid-regulated receptors (BARRs), including GPBAR1, Vitamin D (VDR) RORγT expressed various cell types within entire human body. integrate postbiotics, exerting potential beneficial effects given ability to regulate multiple biological processes such glucose metabolism, energy expenditure inflammation/immunity. Although there evidence might harmful intestine, most this does not account for dysbiosis. This review examines novel conceptual framework secondary postbiotics how these mediators participate in maintaining host health.

Language: Английский

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