Molecular Immunology, Journal Year: 2025, Volume and Issue: 182, P. 54 - 61

Published: April 4, 2025

Natural Killer (NK) cells are a vital element of the innate immune system, and NK cell-based therapies have demonstrated efficacy against various malignancies. However, targeting solid tumors has been challenging due to low infiltration into effective evasion strategies employed by tumors. Recent studies shown that cell derived nanovesicles (NK-NV) can not only replicate functions but also offer more advantages in clinical applications. They capable transporting cellular components such as proteins, nucleic acids, lipids across distances, thereby facilitating intercellular communication among within tumor microenvironment (TME). With progress nanomedical technology, these vesicles be engineered carry range functional elements therapeutic agents enhance their antitumoral capabilities. In this review, we summarize current available literature on NK-NVs, discuss potential biological role non-coding RNAs (ncRNAs), explore application treatment

Language: Английский