The neuroendocrine and endocrine systems in insect – Historical perspective and overview

Molecular and Cellular Endocrinology, Journal Year: 2023, Volume and Issue: 580, P. 112108 - 112108

Published: Nov. 11, 2023

Language: Английский

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Acetylcholine and Malpighian tubules of the kissing bug, Rhodnius prolixus: Evidence for expression of the non-neuronal cholinergic system and a diuretic action of acetylcholine

Journal of Insect Physiology, Journal Year: 2025, Volume and Issue: 161, P. 104752 - 104752

Published: Jan. 29, 2025

Acetylcholine (Ach) and its signaling pathways are expressed in peripheral tissues mammals, leading to the concept of a non-neuronal cholinergic system. This ACh is now known participate as an autocrine/paracrine many processes, including transport ions water, immunity, reproduction. Non-neuronal insects has only recently been explored, with transcriptome analyses disclosing presence transcripts for pivotal components system tissues, Malpighian tubules (MTs), ovaries, hemocytes, fat body. A recent analysis MTs Chagas disease vector Rhodnius prolixus revealed muscarinic receptors acetylcholinesterase, raising possibility that may play role control MTs. Here we provide evidence pathway R. prolixus. Transcripts expressed, capable stimulating small increases secretion by isolated (small, relative true diuretic neurohormones prolixus). The effects mimicked carbachol pilocarpine, atropine inhibiting ACh- pilocarpine-stimulated secretion. Blood gorging alters expression signaling. We discuss physiological relevance since much more than diuresis; they major roles detoxification, tolerance overall stress Perhaps component these essential functions might require increase rate separate from well described rapid post-prandial diuresis.

Language: Английский

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CRF Peptides in Non-mammals

Published: Jan. 1, 2025

Language: Английский

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Current status of innate immune responses in Malpighian tubules of insects: A review focusing on the Toll signaling pathway

Entomological Research, Journal Year: 2024, Volume and Issue: 54(3)

Published: Feb. 29, 2024

Abstract Innate immunity is the immediate and exclusive defense mechanism in invertebrates. It acts against foreign agents pathogens. In insects, this involves a combination of humoral cellular responses, orchestrated by specific recognition receptors activation various signaling pathways. Remarkably, Toll Toll‐related proteins play pivotal role insect inducing production antimicrobial peptides (AMPs) response to pathogen attacks. receptors, which are type I transmembrane proteins, significantly affect development innate immune response, primarily via nuclear factor kappa‐B pathway. The Malpighian tubules insects crucial waste elimination, hemostasis maintenance, defense. pathway mainly involved AMPs. This review provides valuable insights into mechanisms morphological physiological attributes tubules. Moreover, it discusses classification functionalities AMPs synthesized pathogens, thereby contributing our understanding insects.

Language: Английский

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The impact of altered dietary adenine concentrations on the gut microbiota in Drosophila

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 5, 2024

The gut microbiota influences host metabolism and health, impacting diseases. Research into how diet affects microbiome dynamics in model organisms is crucial but underexplored. Herein, we examined dietary adenine uric acid levels the over five generations of

Language: Английский

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Functional characterization of the kinin receptor in the Chagas disease vector Rhodnius prolixus; activity of native kinins and potent biostable Aib-containing insect kinin analogs

Peptides, Journal Year: 2023, Volume and Issue: 172, P. 171135 - 171135

Published: Dec. 14, 2023

Language: Английский

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