Thraustochytrids: Evolution, Ultrastructure, Biotechnology, and Modeling DOI Open Access
А. Г. Мензоров,

Daniil A. Iukhtanov,

Ludmila G. Naumenko

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13172 - 13172

Published: Dec. 7, 2024

The thraustochytrids are a group of marine protists known for their significant ecological roles as decomposers and parasites well potential biotechnological applications, yet evolutionary structural diversity remains poorly understood. Our review critically examines the phylogeny this taxa, utilizing available up-to-date knowledge taxonomic classifications. Additionally, advanced imaging techniques, including electron microscopy, employed to explore ultrastructural characteristics these organisms, revealing key features that contribute adaptive capabilities in varying environments. integration with omics data highlights huge thraustochytrids, particularly producing ω-3 fatty acids other bioactive compounds. underscores importance systems biology approach understanding urgent need novel, accurate research unlock full potential. Overall, aims foster deeper appreciation by synthesizing information on evolution, ultrastructure, practical thereby providing foundation future studies microbiology biotechnology.

Language: Английский

Marine cosmetics and the blue bioeconomy: from sourcing to success stories DOI Creative Commons
Ana Rotter,

Despoina Varamogianni-Mamatsi,

Alenka Zvonar Pobirk

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(12), P. 111339 - 111339

Published: Nov. 7, 2024

As the global population continues to grow, so does demand for longer, healthier lives and environmentally responsible choices. Consumers are increasingly drawn naturally sourced products with proven health wellbeing benefits. The marine environment presents a promising yet underexplored resource cosmetics industry, offering bioactive compounds potential safe biocompatible ingredients. This manuscript provides comprehensive overview of organisms production, highlighting marine-derived their applications in skin/hair/oral-care products, cosmeceuticals more. It also lays down critical safety considerations addresses methodologies sourcing compounds, including harvesting, biorefinery concept, use systems biology enhanced product development, relevant regulatory landscape. review is enriched by three case studies: design macroalgal skincare Iceland, establishment microalgal spin-off Italy, utilization proteins cosmeceutical applications.

Language: Английский

Citations

6
Lipids of Yeasts and Filamentous Fungi and Their Importance to Biotechnology DOI
Volkmar Passoth, Bettina Müller

Grand challenges in biology and biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 163 - 227

Published: Jan. 1, 2025

Language: Английский

Citations

0
Seasonal dynamics of thraustochytrids in mangrove rhizospheres for microbial interactions, PUFA production DOI Creative Commons
Kalidasan Kaliyamoorthy,

K. Kathiresan,

Suchana Chavanich

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 7, 2025

This study investigated seasonal variations of thraustochytrids in rhizosphere soil collected from two mangrove species Rhizophora apiculata and Avicennia marina natural planted stands. Thraustochytrid counts were higher the stand than site. The varied seasonally, being highest post-monsoon season followed by summer, monsoon, pre-monsoon. exhibited positive correlations (p < 0.01) with Total heterotrophic bacteria (THB), azotobacters, actinobacteria, fungi, yeasts, Trichoderma. However, a negative correlation was observed cyanobacteria. also had silt, clay, nitrogen, phosphorus, potassium, chromium, copper, magnesium, cadmium, zinc redox potential, but, temperature, pH, pore water salinity, total organic carbon sand content samples. In present study, 113 thraustochytrid strains isolated habitats. only 48 pure cultures survived after sub-cultured three times. Based on survivability, color, shape, isolates each sampling site selected. predominant 24 identified based their morphological, molecular characteristics classified under five genera: Thraustochytrium, Schizochytrium, Botryochytrium, Parietichytrium, Aurantiochytrium. Among isolates, Aurantiochytrium sp. (AKTSK-06) produced biomass 15.71 g/L (January-March, 2023), (PVTSK-03) accumulated lipid 61.33%. Thraustochytrids found to contain Omega-3 poly unsaturated fatty acids (PUFAs), such as EPA up 8.89% (VRTSK-01), DPA 9.65% (AKTSK-03), DHA 47.46% (AKTSK-06). Thus, mangroves provide an ideal ecological niche for abundant supply omega-3 potential industrial applications.

Language: Английский

Citations

0
Genetic Analysis of Polyunsaturated Fatty Acids Biosynthesis Pathway Determines Four Distinct Thraustochytrid Types DOI Creative Commons

Sou‐Yu Cheng,

Yijing Chen, Hsiu‐Chin Lin

et al.

Environmental Microbiology, Journal Year: 2025, Volume and Issue: 27(4)

Published: March 28, 2025

ABSTRACT Thraustochytrids, diverse marine unicellular protists encompassing over 10 recognised genera, are renowned for synthesising polyunsaturated fatty acids (PUFAs), with content and composition varying substantially across genera. While PUFAs known to be produced via PUFA synthase (PUFA‐S) and/or elongase/desaturase (ELO/DES) pathways, the distinctions in genes involved remain unexplored. This study analysed biosynthetic 19 thraustochytrid strains six categorising them into four types. Type I exclusively utilises ELO/DES pathway, II employs both PUFA‐S complete while Types III IV primarily rely on PUFA‐S, lacking canonical Δ9 desaturase missing most elongase enzymes. Notably, ATP‐citrate lyase ( ACLY ) exclusive II, β‐carotene hydroxylase CrtZ is absent these absence suggests alternative acetyl‐CoA supply pathways IV, whereas implies either a lack of specific xanthophylls or II. Synteny analysis revealed conserved genomic organisation genes, indicating shared evolutionary trajectory. provides insights genetic diversity underlying biosynthesis thraustochytrids, proposing putative lineages.

Language: Английский

Citations

0
Metabolic regulation strategies for enhancing microbial docosahexaenoic acid production by Schizochytrium sp. DOI
Jingwen Liu, Feng Xue, Shang Wang

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(5)

Published: April 28, 2025

Language: Английский

Citations

0
Production of docosahexaenoic acid from furfural residue wastes through integrated whole-cell lignocellulosic saccharification and lipid fermentation by Aurantiochytrium DOI
Xiaojin Song,

Weijian Wan,

Yuedong Zhang

et al.

Bioresource Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132606 - 132606

Published: April 1, 2025

Language: Английский

Citations

0
Thraustochytrids and Algae as Sustainable Sources of Long-Chain Omega-3 Fatty Acids for Aquafeeds DOI Open Access
Christopher C. Parrish

Sustainability, Journal Year: 2024, Volume and Issue: 16(21), P. 9142 - 9142

Published: Oct. 22, 2024

There is limited ability to biosynthesize long-chain omega-3 fatty acids such as EPA and DHA in food webs leading humans. Seafood the key source of ω3 LC-PUFA, with aquaculture expected meet rising global demand; however, marine fish have a high dietary requirement for themselves. This was traditionally met using unsustainable oil meal, but supply environmental concerns dictated research on replacements. Among industrial sources DHA, microalgae especially thraustochytrids stand out resources concentrations. Although unicellular, are not they photosynthetic instead microheterotrophs. removes light facilitates yields monoculture production single-cell oils. The availability, concentrations, usually one or other essential acid permits calibration dose, which useful their effects mainly been considered together medical research. different cell function precursors bioactive compounds. Using thraustochytrids, microalgae, heterotrophic dinoflagellates, importance has investigated. optimizing growth early life stages scallops finfish preferentially incorporated into membrane phospholipids. microheterotrophs can contribute treatment wastewater waste gas, further enhancing sustainability reducing costs aquaculture.

Language: Английский

Citations

2
Thraustochytrids: Evolution, Ultrastructure, Biotechnology, and Modeling DOI Open Access
А. Г. Мензоров,

Daniil A. Iukhtanov,

Ludmila G. Naumenko

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13172 - 13172

Published: Dec. 7, 2024

The thraustochytrids are a group of marine protists known for their significant ecological roles as decomposers and parasites well potential biotechnological applications, yet evolutionary structural diversity remains poorly understood. Our review critically examines the phylogeny this taxa, utilizing available up-to-date knowledge taxonomic classifications. Additionally, advanced imaging techniques, including electron microscopy, employed to explore ultrastructural characteristics these organisms, revealing key features that contribute adaptive capabilities in varying environments. integration with omics data highlights huge thraustochytrids, particularly producing ω-3 fatty acids other bioactive compounds. underscores importance systems biology approach understanding urgent need novel, accurate research unlock full potential. Overall, aims foster deeper appreciation by synthesizing information on evolution, ultrastructure, practical thereby providing foundation future studies microbiology biotechnology.

Language: Английский

Citations

0