The Role of Machine Learning in Predicting Titanium Dioxide Nanoparticles Induced Pulmonary Pathology Using Transcriptomic Biomarkers

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138240 - 138240

Published: April 1, 2025

Language: Английский

Titanium Dioxide Nanoparticles Negatively Influence Gill Metabolism in Pinctada fucata martensii

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 682 - 682

Published: Dec. 5, 2024

Background: In recent years, titanium dioxide (TiO2) nanoparticles (NPs) have been widely used in various industries due to their favorable chemical properties, and contamination of the environment has attracted much attention, especially aquatic animals. Methods: Therefore, we assessed impact TiO2 NPs (5 mg/L) on marine bivalve, pearl oyster (Pinctada fucata martensii), gill metabolism. Pearl oysters were exposed seawater containing 5 mg/L for 14 days, followed by 7 days recovery untreated seawater. Gill tissues hepatopancreatic sampled 0, 14, 21 experiment named C0, E14, R7, respectively. Results: Metabolomic analysis identified 102 significantly different metabolites (SDMs) gills tissue following exposure (C0 vs. E14). Compared with group E14 had 76 SDMs (such as acetylcholine, itaconic acid, citric taurine) higher concentrations 26 (including L-arginine isobutyryl-L-carnitine) lower concentrations. KEGG (Kyoto Encyclopedia Genes Genomes) showed that these enriched 28 pathways, including glycine, serine, threonine metabolism, neuroactive ligand–receptor interaction, taurine hypotaurine addition, 116 R7 oysters. 74 6-phosphogluconic isocitric acid) 42 uracil, glycerophosphocholine, N-Acetyl-D-glucosamine) The between 25 pentose phosphate pathway, glutathione citrate cycle (TCA cycle). energy metabolism-associated enzymes revealed reduced Ca2+/Mg2+-ATPase, Na+/K+-ATPase, Total-ATPase activities. Conclusions: These findings suggested may inhibit metabolism function hepatopancreas Meanwhile, affect normal functioning immune osmoregulatory functions even lead oxidative stress neurotoxicity. this study provide a reference analyzing bioadaptation bivalves potential negative effects bivalves.

Language: Английский

Omics Insights in Responses of Bivalves Exposed to Plastic Pollution

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 279, P. 107224 - 107224

Published: Dec. 28, 2024

Language: Английский