International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4216 - 4216
Published: April 29, 2025
The escalating challenge of antibacterial resistance has driven the widespread use silver nanoparticles (AgNPs) due to their potent antimicrobial properties. AgNPs can be synthesised through diverse methods, spanning conventional chemical and physical routes increasingly favoured biosynthesis approach. While offering environmental advantages, ecological impact biogenically synthesized AgNPs, especially on aquatic ecosystems, requires thorough evaluation. renal system, critical for maintaining physiological homeostasis via nephron-mediated waste removal, fluid regulation, electrolyte balance, is highly vulnerable toxicant-induced damage, which negatively affect organismal fitness. This study aimed assess nephrotoxic effects using entirely “green” zebrafish after 96-h exposures three distinct concentrations alongside a control group. Acridine orange fluorescence microscopy revealed dose-dependent histopathological alterations in tissues. Specifically, at 0.031 μg/L 0.250 μg/L, significant changes were observed, including glomerular shrinkage, proliferation hematopoietic tissue, dissociation dilation tubules, melanomacrophage aggregation. At 5.000 prolonged exposure beyond 48 h indicated potential tissue cell renewal, suggesting possible compensatory response. These results demonstrate sensitivity kidneys emphasize imperative comprehensive vivo toxicity testing, irrespective synthesis method, accurately evaluate adverse impacts ensure preservation ecosystem integrity.
Language: Английский