Targeting Aging Skin with GABALAGEN®: A Synergistic Marine Nutricosmetic Ingredient Validated Through Human Randomized Trials

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 245 - 245

Published: Feb. 20, 2025

This study introduces GABALAGEN® (GBL), a marine-derived ingredient combining low-molecular-weight fish collagen and gamma-aminobutyric acid (GABA) produced via lactobacillus fermentation. GBL contains approximately 10% GABA, making up 39% of its free amino profile. A 12-week, randomized, double-blind, placebo-controlled trial with 100 adults (aged 35-60) assessed effects on aging skin. Participants consumed 1500 mg/day in jelly form, 94% completing the study. By Week 12, group showed 20% increase skin hydration 15% reduction wrinkle depth. Improvements density elasticity were also observed, no adverse reported. In vitro tests demonstrated strong antioxidant anti-inflammatory effects, including enhanced superoxide dismutase activity reduced pro-inflammatory cytokine expression UVB-irradiated keratinocytes. exemplifies sustainable innovation by upcycling fishery byproducts into high-value materials while addressing stability issues common to seafood-derived products. The fermentation process ensures safety enhances GABA's bioavailability. scalable method aligns circular economic principles global sustainability goals, extending GBL's potential other functional which proved their safety. represents breakthrough nutricosmetics, efficacy, environmental sustainability, industrial innovation.

Language: Английский

Medicinal Plant Extracts Targeting UV-Induced Skin Damage: Molecular Mechanisms and Therapeutic Potential

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2278 - 2278

Published: March 4, 2025

The depletion of the ozone layer has intensified ultraviolet (UV) radiation exposure, leading to oxidative stress, DNA damage, inflammation, photoaging, and skin cancer. Medicinal plants, widely used in Traditional Herbal Medicine (THM), particularly Chinese (TCM), have demonstrated significant therapeutic potential due their well-characterized active compounds established photoprotective effects. This review systematically evaluates 18 medicinal plants selected based on traditional use skin-related conditions emerging evidence supporting efficacy against UV-induced damage. Their bioactive components exert antioxidant, anti-inflammatory, repair, depigmentation effects by modulating key signaling pathways, including Nrf2/ARE-, MAPK/AP-1-, PI3K/Akt-, MITF/TYR-related melanogenesis pathways. Moreover, novel drug delivery systems, such as exosomes, hydrogels, nanoemulsions, significantly enhanced stability, bioavailability, penetration these compounds. However, challenges remain standardizing plant-derived formulations, elucidating complex synergistic mechanisms, translating preclinical findings into clinical applications. Future interdisciplinary research technological advancements will be essential harness full for damage prevention treatment.

Language: Английский