Exercise Therapy for Knee Osteoarthritis: A Systematic Review and Network Meta-analysis

Orthopaedic Journal of Sports Medicine, Journal Year: 2023, Volume and Issue: 11(5)

Published: May 1, 2023

Background: Exercise is an effective nonpharmaceutical therapy for knee osteoarthritis (KOA). Purpose: To identify the most type of exercise KOA with regard to pain, stiffness, joint function, and quality life. Study Design: Systematic review; Level evidence, 3. Methods: The PubMed, Web Science, Embase, Cochrane Library databases were searched, from inception April 4, 2022. Included randomized controlled trials that assessed efficacy on among 5 different groups (aquatic [AE], stationary cycling [CY], resistance training [RT], traditional [TC], yoga [YG]) compared control group. Outcomes Western Ontario McMaster University Osteoarthritis Index (WOMAC), 6-minute walk test (6-MWT), visual analog scale (VAS) Knee injury Outcome Score (KOOS); weighted mean differences (WMDs) 95% confidence intervals calculated. Network meta-analyses comparing outcomes between all controls performed, group rankings calculated using surface under cumulative ranking curve (SUCRA). Results: A total 39 studies (N = 2646 participants) included. Most failed blind participants researchers, resulting in a high risk performance bias. Significantly worse WOMAC-Pain scores seen interventions except AE (WMD [95% CI]: CY, –4.45 [–5.69 –3.20]; RT, –4.28 [–5.48 –3.07]; TC, –4.20 [–5.37 –3.04]; YG, –0.57 [–1.04 –1.04]), YG regarding WOMAC-Stiffness (WMD, –1.40 CI, –2.45 –0.34]) WOMAC-Function –0.49 –0.95 –0.02]). According SUCRA, CY was improving (80.8%) 6-MWT (76.1%); (90.6%), (77.4%), KOOS–Activities Daily Living (72.0%), KOOS–Quality Life (79.1%); VAS pain (77.2%) KOOS-Pain (64.0%); RT KOOS-Symptoms (84.5%). Conclusion: All types able ameliorate KOA. (for relief) limited life) approaches, followed by TC.

Language: Английский

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Non-Pharmacological Pain Management for Osteoarthritis: Review Update

Current Rheumatology Reports, Journal Year: 2025, Volume and Issue: 27(1)

Published: Feb. 19, 2025

Language: Английский

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Effectiveness of Yijinjing exercise in the treatment of early-stage knee osteoarthritis: a randomized controlled trial protocol

BMJ Open, Journal Year: 2024, Volume and Issue: 14(3), P. e074508 - e074508

Published: March 1, 2024

Introduction Knee osteoarthritis (KOA) is still a challenging degenerative joint disease with high morbidity and burden. Early-stage KOA, the focus of this study, could present Window Opportunity to arrest process reduce Yijinjing exercise an important part physical psychological therapies in Traditional Chinese Exercise may be effective treatment. However, there no clinical efficacy assessment for patients early-stage KOA. Therefore, we designed randomised controlled trial evaluate effectiveness on Methods analysis This parallel-design, two-arm, analyst assessor-blinded, trial. In total, 60 KOA will recruited randomly assigned group (n=30) health education at ratio 1:1, receiving 12 weeks or accordingly. The primary outcome measured Western Ontario McMaster Universities Osteoarthritis Index, secondary outcomes include Visual Analogue Scale, Short-Form 36 Item Health Survey Questionnaire, Beck Depression Inventory, Perceived Stress Berg Balance Gait Analysis comprehensive assessment. Outcome measures are collected baseline, week ending intervention week, 24 48 follow-up. primay time point postintervention. Adverse events recorded safety Ethics dissemination study has been approved by ethical application Shanghai Municipal Hospital Medicine Committee (2021SHL-KY-78). Trial registration number ChiCTR2200065178

Language: Английский

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Traditional Chinese Rehabilitation Exercise (TCRE) for Myofascial Pain: Current Evidence and Further Challenges

Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 2801 - 2810

Published: Aug. 1, 2024

Myofascial as a holistic structure emphasizes approach to intervention and treatment of fascial-related disorders such neck pain (NP), low back (LBP), knee pain. There are currently adverse effects medication for diseases related myofascial. Traditional Chinese rehabilitation exercise (TCRE) is practical traditional medicine valuable option intervening in myofascial-related This article found some research evidence Baduanjin, Wuqinxi, Yijinjing clinical studies myofascial chain-related The summarizes the current finds that TCRE can enhance limb movement function through breathing slow movements, increase joint flexibility, reduce pathology stress-induced As future directions, focus on improving health older adults treating long-COVID syndrome, integrate robotic training frame safe effective models. Relevant have already been registered Clinical Trials Registry, study protocols published. be an alternative nonpharmacological therapy alleviate chronic rheumatic symptoms augment public management.

Language: Английский

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Hybrid Exercise Program for Sarcopenia in Older Adults: The Effectiveness of Explainable Artificial Intelligence-Based Clinical Assistance in Assessing Skeletal Muscle Area

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(16), P. 9952 - 9952

Published: Aug. 12, 2022

Background: Sarcopenia is a geriatric syndrome characterized by decreased skeletal muscle mass and function with age. It well-established that resistance exercise Yi Jin Jing improve the of older adults sarcopenia. Accordingly, we designed an program incorporating to increase reverse sarcopenia in adults. Additionally, machine learning simulations were used predict status after intervention. Method: This randomized controlled trial assessed effects For 24 weeks, 90 divided into intervention groups, including training group (YR, n = 30), (RT, control (CG, 30). Computed tomography (CT) scans abdomen quantify cross-sectional area at third lumbar vertebra (L3 SMA). Participants’ age, body mass, stature, BMI characteristics analyzed one-way ANOVA chi-squared test for categorical data. study explored improvement effect three interventions on participants’ L3 SMA, density SMD), interstitial fat region interest SMFA), SMFD), relative index (RSMI), infiltration (MFI), handgrip strength. Experimental data using two-way repeated-measures ANOVA. Eleven models trained tested 100 times assess model’s performance predicting whether could be reversed following Results: There was significant interaction SMA (p < 0.05), RSMI MFI strength 0.05). After intervention, participants YR RT groups showed improvements RSMI, Post hoc tests 0.05) yielded significantly better than CG Compared other models, stacking model exhibits best terms accuracy (85.7%) F1 (75.3%). Conclusion: One hybrid can among it possible based our model.

Language: Английский

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Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Aug. 10, 2022

Objective Although Traditional Chinese Yijinjing Qigong Exercise (YJJQE) as mind–body intervention is popularly used among adults to ameliorate depressive symptoms in China, no randomized controlled trials (RCTs) are available evaluate the effects of YJJQE patients with poststroke depression (PSD). This study aims explore clinical efficacy and neurological psychiatric mechanism brain network functional connectivity underlying electroencephalography (EEG). Materials methods A total 60 patients, diagnosed mild PSD, were randomly (1:1) assigned group ( n = 30) control routine segmental rehabilitation training for a 60-min exercise session once day 3 weeks. All outcome measures collected at baseline 3-weeks ending intervention. The primary was 24-item Hamilton Depression Scale (HAMD-24) score, evaluation more time points 1 month follow-up. secondary outcomes EEG data four frequency domains (δ, θ, α, β), global efficiency (GE), local (LE), GE/LE curve [areas under (AUC)], Phase Lag Index (PLI), Score correlation analysis. Results showed significant differences data. After weeks follow-up, demonstrated decreasing changes compared on HAMD-24 scores p &lt; 0.001). Furthermore, also reduction θ wave, an increase both GE LE. Compared group, significantly greater δ, β bands degree phase synchronization analysis negative wave Conclusion Our findings that estimated effectively alleviate depressed mood PSD by promoting information transmission its integration ability different regions. Therefore, would be useful non-pharmacological treatment prevent PSD. Clinical trial registration [ http://www.chictr.org.cn/showproj.aspx?proj=55789 ], identifier [ChiCTR2000035588].

Language: Английский

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Exercise training-attenuated insulin resistance and liver injury in elderly pre-diabetic patients correlates with NLRP3 inflammasome

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 1, 2023

Diabetes is one of the most common metabolic diseases and continues to be a leading cause death worldwide. The NLRP3 inflammasome has been shown exert detrimental effects on diabetic models. However, evidence linking pre-diabetes scarcely explored. Herein, we aimed determine whether correlates with insulin resistance liver pathology in cohort pre-diabetic subjects.50 subjects were randomly assigned Pre-diabetes Control (DC, n=25) exercise (DEx, group. 25 Normal (NC) selected as controls. DEx group performed 6-month combined Yijingjing training intervention, while DC NC remained daily routines. Clinical parameters determined an automatic biochemistry analyzer; inflammatory cytokines quantified by ELISA assay; protein expressions components PBMCs evaluated Western Blot.The resistance, injury activity higher individuals than normal control intervention counteracted this trend, significantly improved sensitivity, reduced inhibited overactivation subjects. Moreover, positive correlations between also found.Our study suggests that effective strategy alleviate elderly which probably associated inhibition activity.

Language: Английский

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Effect of Wu Qin Xi exercises on pain and function in people with knee osteoarthritis: A systematic review and meta-analysis

Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 7, 2022

As a chronic disease that affects the whole world, there is no definite treatment for knee osteoarthritis (KOA). Wu Qin Xi (WQX) still in preliminary exploration as traditional Chinese exercise of knee. The purpose this study was to conduct meta-analysis previous studies and investigate efficacy WQX exercises on pain function patients with KOA.We searched six databases (Pubmed, Embase, Cochrane Library, Wanfang, CQVIP, CNKI) articles KOA up May 10, 2022. Literature search, selection, data extraction, quality evaluation were performed by two independent authors. In terms statistical results, we presented mean differences (MD), 95% CI, I2 show heterogeneity, and, based that, chose either random effects model or fixed model.Seven selected inclusion meta-analysis. intervention group showed both total Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) score its various bylaws, Visual Analogue Score (VAS), presence general functional control group. We also demonstrated clinically meaningful calculating minimum clinical importance difference (MCID) values met MCID WOMAC score. A sensitivity analysis subgroup greater it inferred follow-up time likely source heterogeneity.Despite some limitations, current effect improving symptoms joint KOA.https://www.crd.york.ac.uk/prospero/, identifier: CRD42022332209.

Language: Английский

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Long- and short-term effectiveness of traditional Chinese exercises in improving the overall physical capacity of patients with knee osteoarthritis: A systematic review and meta-analysis

Medicine, Journal Year: 2024, Volume and Issue: 103(36), P. e39520 - e39520

Published: Sept. 6, 2024

Background: The increasing global popularity of traditional Chinese exercise (TCE) provides substantial evidence its significant efficacy in treating knee osteoarthritis (KOA). To assess the impact different types TCE and varying durations on KOA patients, we conducted a systematic review meta-analysis randomized controlled trials (RCTs) this topic. Methods: Two investigators extensively searched four electronic databases (PubMed, Embase, Cochrane, Web Science) from their inception until December 16, 2023, to identify all relevant RCTs use for treatment. included studies were assessed risk bias using Cochrane Collaboration Risk Bias Tool (CCRBT), data analysis was performed Stata 15.0. Results: A total 20 RCTs, involving 1367 patients with KOA, met inclusion criteria. Compared control group, demonstrated improvement three subscale scores Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) [Pain (SMD = −0.44; P .0001); Stiffness −0.35; .001); Physical function −0.52; .0001)] two 36-item Short-Form (SF-36) [Physical score (WMD 2.76; Mental 2.49; patients. Subgroup showed that both long-term habitual (over 12 weeks) short-term (within more effective than group improving pain, joint stiffness, physical Tai Chi, among modalities analyzed, improvements indicators. Conclusion: Based results our meta-analysis, it can be concluded interventions are alleviating main symptoms patients’ function. However, due limited methodological quality inconsistent outcome measures further high-quality larger sample sizes longer-term necessary validate findings before recommended as treatment KOA.

Language: Английский

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Role of exercise on pain, functional capacity, and inflammatory biomarkers in osteoarthritis: A systematic review and meta-analysis

Annals of Physical and Rehabilitation Medicine, Journal Year: 2025, Volume and Issue: 68(3), P. 101909 - 101909

Published: Jan. 10, 2025

Language: Английский

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