Reduced autonomic function in patients with long-COVID-19 syndrome is mediated by cardiorespiratory fitness

Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: 49(9), P. 102732 - 102732

Published: July 1, 2024

Long-COVID-19 syndrome (LCS) exhibits neurological problems such as peripheral neuropathy and autonomic nervous system (ANS) dysfunction. Exercise intolerance and, consequently, low cardiorespiratory fitness (CRF) are some of the most common symptoms LCS. We describe a series individuals exhibiting LCS compared to control group posit that this condition may be related exercise capacity-mediated disruption ANS resulting particularly in intolerance.

Language: Английский

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Induced Relaxation Enhances the Cardiorespiratory Dynamics in COVID-19 Survivors

Entropy, Journal Year: 2023, Volume and Issue: 25(6), P. 874 - 874

Published: May 30, 2023

Most COVID-19 survivors report experiencing at least one persistent symptom after recovery, including sympathovagal imbalance. Relaxation techniques based on slow-paced breathing have proven to be beneficial for cardiovascular and respiratory dynamics in healthy subjects patients with various diseases. Therefore, the present study aimed explore cardiorespiratory by linear nonlinear analysis of photoplethysmographic time series under a psychophysiological assessment that includes breathing. We analyzed signals 49 assess rate variability (BRV), pulse (PRV), pulse-respiration quotient (PRQ) during assessment. Additionally, comorbidity-based was conducted evaluate group changes. Our results indicate all BRV indices significantly differed when performing Nonlinear parameters PRV were more appropriate identifying changes patterns than indices. Furthermore, mean standard deviation PRQ exhibited significant increase while sample fuzzy entropies decreased diaphragmatic Thus, our findings suggest may improve short term enhancing coupling via increased vagal activity.

Language: Английский

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The Impact of COVID-19 upon Intracardiac Hemodynamics and Heart Rate Variability in Stable Coronary Artery Disease Patients

Ukrainian journal of cardiovascular surgery, Journal Year: 2023, Volume and Issue: 31(1), P. 19 - 28

Published: March 27, 2023

The aim. To study the impact of COVID-19 upon intracardiac hemodynamics and heart rate variability (HRV) in stable coronary artery disease (SCAD) patients. Materials methods. In this cross-sectional we analyzed clinical instrumental data obtained from a sample 80 patients. patients were divided into three groups: group 1 included with SCAD without (n=30), 2 (n=25), 3 (n=25). control 30 relatively healthy volunteers. Results. changes HRV characterized by impaired left ventricular systolic diastolic function, dilation both ventricles elevated pulmonary pressure. Left end-diastolic volume was higher (205±21 ml) than that (176±33 ml; р<0.001) (130±21 р<0.001). Patients groups 1–3, compared to controls, presented decrease overall (by standard deviation [SD] all NN intervals [SDNN]; SD averages 5 min segments entire recording; mean SDs for recording) parasympathetic activity (root-mean-square difference successive intervals; proportion derived dividing number interval differences greater 50 ms [NN50] total [pNN50], high frequency spectral component), along QT prolongation increase its variability. Group demonstrated most advanced SDNN pNN50) characteristics. Conclusions. concomitant COVID-19, impairment, sings autonomic dysfunction, characteristics should be additionally considered management such

Language: Английский

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Long-term sequelae of coronavirus disease: long COVID-19 and cardiovascular outcomes (a literature review)

Zaporozhye Medical Journal, Journal Year: 2024, Volume and Issue: 26(3), P. 223 - 233

Published: May 31, 2024

The COVID-19 pandemic has serious global implications for the healthcare system and economy. Although recovery rate increased significantly morbidity decreased, long-term consequences, particularly cardiovascular, have come to fore become a problem. As result, in 2021, at WHO level, concept of “long-term COVID” was introduced, including more than 100 already described symptoms patients least 3 months after initial recovery. At same time, clinical are not specific, strategies treatment such disorders been worked out, measures detect and/or prevent development these complications organized. aim: summarize available data modern views on cardiovascular effects COVID-19, reveal probable causes risk factors their development, as well analyze presented information pathogenetic mechanisms consequences coronavirus disease. literature analysis shown that SARS-CoV-2 viral persistence human body, reactivation other agents, immune dysregulation, autoimmunization occurrence microvascular thrombosis endothelial dysfunction among long COVID. all findings represent theoretical concepts regarding pathogenesis disease, complementing interacting with each other, moment, there is no formulated uniform explanation COVID-19. Also, large-scale studies point need special attention Among those myocarditis, pericarditis, heart failure, arterial hypertension, arrhythmias, pulmonary embolism, cerebrovascular disorders, cardiomyopathy. Given prevalence diseases impact mortality, processes threat context pandemic. Conclusions. COVID analyzed, COVID-related from acute disease examined detail. study this issue extremely important since only by understanding association between diseases, studying identifying factors, it possible improve prevention take control over level.

Language: Английский

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The negative effects of long COVID-19 on cardiovascular health and implications for the presurgical examination

Journal of Osteopathic Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

In 2019, emergence of the novel and communicable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection took scientific communities by surprise imposed significant burden on healthcare systems globally. Although advent this disease piqued interest academic centers, systems, general public, there is still much yet to be elucidated regarding epidemiology, pathophysiology, long-term impacts 2019 (COVID-19). It has been established that long COVID-19 can impact multiple organ including cardiovascular system, unfavorably. pathophysiology damage not well understood, adverse sequelae may range from chest pain arrhythmias heart failure (HF), myocardial infarction, or sudden cardiac death. For any postacute patient requiring a surgical procedure, potential for injury secondary must considered in preoperative examination.

Language: Английский

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SARS-CoV-2 Infection and Alpha-Synucleinopathies: Potential Links and Underlying Mechanisms

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12079 - 12079

Published: Nov. 10, 2024

Alpha-synuclein (α-syn) is a 140-amino-acid, intrinsically disordered, soluble protein that abundantly present in the brain. It plays crucial role maintaining cellular structures and organelle functions, particularly supporting synaptic plasticity regulating neurotransmitter turnover. However, for reasons not yet fully understood, α-syn can lose its physiological begin to aggregate. This altered disrupts dopaminergic transmission causes both presynaptic postsynaptic dysfunction, ultimately leading cell death. A group of neurodegenerative diseases known as α-synucleinopathies characterized by intracellular accumulation deposits specific neuronal glial cells within certain brain regions. In addition Parkinson's disease (PD), these conditions include dementia with Lewy bodies (DLBs), multiple system atrophy (MSA), pure autonomic failure (PAF), REM sleep behavior disorder (RBD). Given disorders are associated α-syn-related neuroinflammation-and considering SARS-CoV-2 infection has been shown affect nervous system, COVID-19 patients experiencing neurological symptoms-it proposed may contribute neurodegeneration PD other promoting misfolding aggregation. this review, we focus on whether could act an environmental trigger facilitates onset or progression α-synucleinopathies. Specifically, new evidence potential modulating function discuss causal relationship between development parkinsonism-like symptoms.

Language: Английский

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An exercise immune fitness test to unravel mechanisms of Post-Acute Sequelae of COVID-19

Expert Review of Clinical Immunology, Journal Year: 2023, Volume and Issue: 19(7), P. 693 - 697

Published: May 16, 2023

KEYWORDS: Exercise testingcardiorespiratory-immunological fitnessPost-Acute Sequelae of COVIDMyalgic-Encephalopathy/Chronic Fatigue Syndromepost-exertional malaiseimmune system failure

Language: Английский

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COVID-19’s Hidden Shield: How Post-Infection Hearts Safeguard Against Atrial Contractions

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 7, 2024

Abstract Background: Ectopic atrial contractions, also known as premature contractions (PACs), are abnormal heart rhythms originating from the atria (the upper chambers of heart). These occur earlier than expected during cardiac cycle and can disrupt normal rhythm. While they generally benign, their presence sometimes cause symptoms such palpitations. The exact mechanisms linking COVID-19 EACs not fully understood, some evidence suggests that infection increase risk developing or other types arrhythmias. Objectives: Effects EAC on post-COVID-19 patients Materials Methods: This is a case‒control study middle-aged individuals either sex involving 50 adult with (eight were excluded because cooperative), 23 females 19 males mean age 36.98 ± 12.2 years who vaccinated against after one month to two an acute episode (confirmed by positive real-time reverse-transcription polymerase chain reaction (RT‒PCR)) according World Health Organization (WHO) selected randomly those attending Holter Echocardiography Laboratory in Al-Zahraa Hospital/Al-Hussein Medical City/Karbala Province being referred internist period 12th October 2022 end January 2024 divided into three groups: nonhospitalize, hospitalize admitted intensive care. control group consisted 40 healthy persons, 17 33.28 9.58 years, for ECG echocardiography no Hx previous COVID-19. All them underwent electrocardiographic evaluation via 24 hours. Conclusion: Post-COVID-19 had lower patients, indicating it may have protective effect reduce

Language: Английский

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Long-term impact of COVID-19 on the cardiovascular system

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 77 - 96

Published: Jan. 1, 2024

Language: Английский

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A Feasibility Study on a Multidisciplinary Rehabilitation Program Including Whole-Body Cryostimulation in Patients With Obesity and Post-COVID Condition

Published: Oct. 24, 2023

Background: Post-Covid condition can reduce activity and quality of life, resulting in a significant socioeconomic health burden. Understanding its impact on patients&#039; is important for the development personalized rehabilitation interventions. An independent association between obesity post-covid was found because complications comorbidities. Methods: Sixteen patients with post-COVID symptoms (i.e., dyspnea, pain, poor sleep quality, muscle fatigue) admitted to Istituto Auxologico Italiano, Piancavallo (VB), Italy, were recruited four-week program including conventional exercise therapy, nutritional intervention, psychological support whole-body cryostimulation (WBC). Results: All participants attended all sessions program. Anthropometric data showed statistically changes weight, waist circumference body mass index. Biochemical analyses reductions lipid inflammatory profiles. There improvement physical performance, reduction pain well-being. Conclusion: A multidisciplinary protocol WBC designed safe feasible. The overall improvements demonstrate that effective post COVID suggest use could play role as booster programs.

Language: Английский

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