Polyphenols: a route from bioavailability to bioactivity addressing potential health benefits to tackle human chronic diseases

Archives of Toxicology, Journal Year: 2022, Volume and Issue: 97(1), P. 3 - 38

Published: Oct. 19, 2022

Language: Английский

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Exposure to environmental pollutants selects for xenobiotic-degrading functions in the human gut microbiome

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 27, 2024

Abstract Environmental pollutants from different chemical families may reach the gut microbiome, where they can be metabolized and transformed. However, how our symbionts respond to exposure environmental pollution is still underexplored. In this observational, cohort study, we aim investigate influence of on microbiome composition potential activity by shotgun metagenomics. We select as a case study population living in highly polluted area Campania region (Southern Italy), proposed an ideal field for exposomic studies compare fecal 359 subjects areas with high, medium low pollution. highlight changes functionality that were driven exposure. Subjects show higher blood concentrations dioxin heavy metals, well increase microbial genes related degradation and/or resistance these molecules. Here demonstrate dramatic effect xenobiotics have communities, shaping their boosting selection strains degrading capacity. The considered pivotal player environment-health interaction contribute detoxifying toxic compounds should taken into account when developing risk assessment models. was registered at ClinicalTrials.gov identifier NCT05976126.

Language: Английский

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Aquatic Microbiomes Under Stress: The Role of Gut Microbiota in Detoxification and Adaptation to Environmental Exposures

Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100612 - 100612

Published: Jan. 1, 2025

Language: Английский

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Deleterious Effect of Air Pollution on Human Microbial Community and Bacterial Flora: A Short Review

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(23), P. 15494 - 15494

Published: Nov. 22, 2022

A balanced microbiota composition is requisite for normal physiological functions of the human body. However, several environmental factors such as air pollutants may perturb composition. It noticeable that currently around 99% world’s population breathing polluted air. Air pollution’s debilitating health impacts have been studied scrupulously, including in gut microbiota. Nevertheless, impact on other microbiotas body less understood so far. In present review, authors summarized and discussed recent studies’ outcomes related to pollution-driven microbiotas’ dysbiosis (including oral, nasal, respiratory, gut, skin, thyroid microbiotas) its potential multi-organ risks.

Language: Английский

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Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 2237 - 2254

Published: Nov. 1, 2024

Organophosphates (OPs) refers to a diverse group of phosphorus-containing organic compounds; they are widely used all over the world and have had an important beneficial impact on industrial agricultural production control vector transmission. Exposure OPs different toxicities (high, moderate, slight, low toxicity) can negative consequences nervous system, such as nausea, vomiting, muscle tremors, convulsions. In severe cases, it lead respiratory failure or even death. Notably, induce neuropathy in system through specific interactions with nicotinic muscarinic receptors, phosphorylating acetylcholinesterase, neuropathic target esterases. This review summarizes possible toxicological mechanisms their interplay underlying OP pesticide poisoning, including cholinesterase inhibition non-cholinesterase mechanisms. It outlines links between poisoning neurological disorders, dementia, neurodevelopmental diseases, Parkinson's disease. Additionally, explores interactions' potential therapeutic implications that may help mitigate deleterious system.

Language: Английский

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Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 167, P. 117248 - 117248

Published: Aug. 21, 2023

The human microbiome and its metabolic output play an important role in shaping health disease. host-microbe crosstalk is often characterised using metabolomics metagenomics, yet a large proportion of microbial metabolites the molecular functions gut microbes remain unknown. This review summarises strategies for annotation discovery novel from microbiome, either alone or combination with presents data analysis methods combining these two types to obtain biological insights. Applications research biomarker screening, precision medicine, drug are also discussed, along perspectives, challenges limitations this field.

Language: Английский

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Chronic Exposure to Drinking Water As, Pb, and Cd at Provisional Guideline Values Reduces Weight Gain in Male Mice via Gut Microflora Alterations and Intestinal Inflammation

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(35), P. 12981 - 12990

Published: Aug. 24, 2023

Few studies have investigated the long-term effect of exposure to arsenic (As), lead (Pb), and cadmium (Cd) via drinking water at provisional guideline values on gut microflora. In this study, male female mice were exposed As, Pb, or Cd 10, 5 μg L–1 for 6 months. At end exposure, net weight gain As Pb (9.91 ± 1.35 11.2 1.50 g) was significantly (p < 0.05) lower compared unexposed control (14.1 3.24 g), while not observed mice. Relative abundance Akkermansia, a protective bacterium against intestinal inflammation, reduced from 29.7% 3.20%, 4.83%, 17.0% after in mice, which likely caused chronic as suggested by 2.81- 9.60-fold higher mRNA levels pro-inflammatory factors ileal enterocytes These results indicate that concentrations equivalent China can cause loss bacteria thereby affecting body

Language: Английский

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Maternal exposure of mice to glyphosate induces depression- and anxiety-like behavior in the offspring via alterations of the gut-brain axis

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 167034 - 167034

Published: Sept. 13, 2023

Language: Английский

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Exploring environmental exposomes and the gut-brain nexus: Unveiling the impact of pesticide exposure

Environmental Research, Journal Year: 2024, Volume and Issue: 250, P. 118441 - 118441

Published: Feb. 11, 2024

Language: Английский

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Microbiota-Induced Epigenetic Alterations in Depressive Disorders Are Targets for Nutritional and Probiotic Therapies

Genes, Journal Year: 2023, Volume and Issue: 14(12), P. 2217 - 2217

Published: Dec. 14, 2023

Major depressive disorder (MDD) is a complex and leading cause of disability in 280 million people worldwide. Many environmental factors, such as microbes, drugs, diet, are involved the pathogenesis disorders. However, underlying mechanisms depression include interaction genetics with epigenetics host immune system. Modifications gut microbiome its metabolites influence stress-related responses social behavior patients disorders by modulating maturation cells neurogenesis brain mediated epigenetic modifications. Here, we discuss potential roles leaky development via changes microbiota-derived effects. Next, will deliberate how altering composition contributes to alterations. In particular, focus on butyrate an modifier, probiotics, maternal polyphenols, drugs (e.g., antipsychotics, antidepressants, antibiotics), fecal microbiota transplantation could positively alleviate depressive-like behaviors landscape. Finally, challenges associated recent therapeutic approaches for microbiome-related shifts, well opportunities tackle problems.

Language: Английский

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