International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3707 - 3707
Published: April 14, 2025
The
AGE
(advanced
glycation
end-products)–RAGE
(receptor
for
AGE)
system
is
a
pro-inflammatory
pathway
that
contributes
to
the
pathogenesis
of
obesity
and
obesity-related
cardiovascular
disorders
(CVD).
Circulating
soluble
form
RAGE
(sRAGE)
has
been
suggested
as
potential
biomarker
CVD
related
obesity.
In
this
study,
we
aim
(1)
summarize
current
knowledge
about
role
in
onset
progression
CVD,
(2)
discuss
AGE–RAGE
promoting
linking
(3)
highlight
available
strategies
reducing
activation
associated
beneficial
effects.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 212 - 212
Published: Feb. 13, 2025
Methylglyoxal
(MGO),
a
by-product
of
glycolysis,
plays
significant
role
in
cellular
metabolism,
particularly
under
stress
conditions.
However,
MGO
is
potent
glycotoxin,
and
its
accumulation
has
been
linked
to
the
development
several
pathological
conditions
due
oxidative
stress,
including
diabetes
mellitus
neurodegenerative
diseases.
This
paper
focuses
on
biochemical
mechanisms
by
which
contributes
through
formation
advanced
glycation
end
products
(AGEs),
interactions
with
antioxidant
systems,
involvement
chronic
diseases
like
diabetes,
neurodegeneration,
cardiovascular
disorders.
exerts
effects
multiple
signaling
pathways,
NF-κB,
MAPK,
Nrf2,
induce
stress.
Additionally,
triggers
apoptosis
primarily
via
intrinsic
extrinsic
while
endoplasmic
reticulum
(ER)
mediated
PERK-eIF2α
IRE1-JNK
signaling.
Moreover,
activation
inflammatory
RAGE
crucial
pathogenesis
these
study
points
out
connection
between
carbonyl
increased
formation,
it
should
be
an
incentive
search
for
marker
that
could
have
prognostic
significance
or
targeted
therapeutic
intervention
various
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 392 - 392
Published: March 26, 2025
Glycation
is
a
process
in
which
reducing
sugars
bind
to
proteins,
resulting
the
formation
of
advanced
glycation
end
products
(AGEs).
These
AGEs
accumulate
skin,
promote
excessive
collagen
crosslinking,
and
disrupt
extracellular
matrix
(ECM),
impairing
normal
cellular
functions
contributing
skin
aging.
To
evaluate
anti-glycation
efficacy
lotus
stamen
extract
(LSE),
we
employed
BSA–fructose
system
high
glucose
(HG)-induced
fibroblast
model.
The
results
demonstrated
that
LSE
effectively
inhibited
also
exhibited
anti-inflammatory,
antioxidative,
anti-senescent
effects
HG-induced
human
fibroblasts
(HSF).
Further
investigation
into
mechanism
component
analysis
ethyl
acetate
(LSEE)
led
identification
15
flavonoids.
indicated
these
flavonoids
are
likely
primary
active
constituents
LSE.
Mechanistic
studies
revealed
GLO1
plays
crucial
role
resistance
glycation,
LSEE
enhanced
expression
through
Nrf2/Keap1
pro-survival
pathway,
thereby
mitigating
intracellular
AGE
production.
In
summary,
its
multiple
flavonoid
components
exhibit
potent
activity
present
significant
potential
be
developed
as
natural
organic
product
for
cosmetic
healthcare
applications.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3707 - 3707
Published: April 14, 2025
The
AGE
(advanced
glycation
end-products)–RAGE
(receptor
for
AGE)
system
is
a
pro-inflammatory
pathway
that
contributes
to
the
pathogenesis
of
obesity
and
obesity-related
cardiovascular
disorders
(CVD).
Circulating
soluble
form
RAGE
(sRAGE)
has
been
suggested
as
potential
biomarker
CVD
related
obesity.
In
this
study,
we
aim
(1)
summarize
current
knowledge
about
role
in
onset
progression
CVD,
(2)
discuss
AGE–RAGE
promoting
linking
(3)
highlight
available
strategies
reducing
activation
associated
beneficial
effects.
