Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(4), P. 838 - 860
Published: June 22, 2023
Language: Английский
Cancers, Journal Year: 2023, Volume and Issue: 15(7), P. 2128 - 2128
Published: April 3, 2023
Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) radio- chemo-resistance limit their effectiveness result in unfavorable consequences. Natural compounds are generally considered safer than synthetic drugs, use cancer treatment alone, or combination with conventional therapies, is increasingly becoming accepted. Interesting outcomes from pre-clinical trials using Baicalein medicines have been reported, some of them also undergone clinical later stages. As a result, we investigated the prospects Baicalein, naturally occurring substance extracted stems Scutellaria baicalensis Georgi Oroxylum indicum Kurz, which targets wide range molecular changes that involved development. In other words, this review primarily driven by findings studies therapy several cell populations based on promising research. The modifications numerous signal transduction mechanisms transcriptional agents highlighted as major players Baicalein’s anti-malignant properties at micro level. These include AKT serine/threonine protein kinase B (AKT) well PI3K/Akt/mTOR, matrix metalloproteinases-2 & 9 (MMP-2 9), Wnt/-catenin, Poly(ADP-ribose) polymerase (PARP), Mitogen-activated (MAPK), NF-κB, Caspase-3/8/9, Smad4, Notch 1/Hes, Signal transducer activator transcription 3 (STAT3), Nuclear factor erythroid 2-related 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap 1), Adenosine monophosphate-activated (AMPK), Src/Id1, ROS signaling, miR 183/ezrin, Sonic hedgehog (Shh) signaling cascades. promise anti-inflammatory to anti-apoptotic/anti-angiogenic/anti-metastatic medicinal element treating various malignancies its capability inhibit malignant stem cells, evidence synergistic effects, design nanomedicine-based drugs altogether supported data presented study.
Language: Английский
Citations
44
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 2, 2024
Abstract Neurodegenerative disorders are complex, progressive, and life-threatening. They cause mortality disability for millions of people worldwide. Appropriate treatment neurodegenerative diseases (NDs) is still clinically lacking due to the presence blood-brain barrier (BBB). Developing an effective transport system that can cross BBB enhance therapeutic effect neuroprotective agents has been a major challenge NDs. Exosomes endogenous nano-sized vesicles naturally carry biomolecular cargoes. Many studies have indicated exosome content, particularly microRNAs (miRNAs), possess biological activities by targeting several signaling pathways involved in apoptosis, inflammation, autophagy, oxidative stress. Exosome content influence cellular function healthy or pathological ways. Furthermore, since exosomes reflect features parental cells, their cargoes offer opportunities early diagnosis intervention diseases. unique characteristics make them ideal delivering drugs directly brain. These include ability pass through BBB, biocompatibility, stability, innate properties. This review emphasizes role alleviating NDs discusses associated molecular mechanisms. exosomes, making promising natural transporter various medications brain combat NDs, also discussed.
Language: Английский
Citations
27
Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 396, P. 111055 - 111055
Published: May 17, 2024
Language: Английский
Citations
10
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Aug. 2, 2024
Ashwagandha or Withania somnifera is an herbal plant belonging to the Solanaceae family. Because of its wide range phytochemicals, ashwagandha root extract has been used in numerous research studies, either alone conjunction with other natural plants, for various biomedical applications, which include anti-microbial, anti-inflammatory, anti-stress, anti-tumor, cardioprotective, and neuroprotective properties. Additionally, it improves endothelial function, lowers reactive oxygen species, controls apoptosis, mitochondrial function. These properties make a useful treatment variety conditions, including age-related symptoms, anxiety, neurodegenerative diseases, diabetes, stress, arthritis, fatigue, cognitive/memory impairment. Despite benefits supplementation, there have just four meta-analyses on herb's effectiveness treating neurobehavioral disorders, impotence, infertility. Moreover, no reviews exist that examine how affects antioxidant response physical sports performance. Consequently, goal this study was analyze scientific literature regarding effects consumption athletic
Language: Английский
Citations
8
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 297 - 297
Published: Feb. 28, 2025
Oxidative stress (OS) is an important factor in the pathophysiology of numerous neurodegenerative disorders, such as Parkinson's disease, multiple sclerosis, cerebrovascular pathology or Alzheimer's disease. OS also significantly influences progression among various disorders. The imbalance between formation reactive oxygen species (ROS) and body's capacity to neutralize these toxic byproducts renders brain susceptible oxidative injury. Increased amounts ROS can result cellular malfunction, apoptosis neurodegeneration. They represent a substantial mitochondrial dysfunction, defining characteristic Comprehending fundamental mechanisms its interactions with function, neuroinflammation protective pathways becomes essential for formulating targeted therapeutics maintain health reduce impacts We address recent highlights on role function terms significance neuronal
Language: Английский
Citations
1
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(12), P. 5509 - 5528
Published: Aug. 28, 2023
Abstract The pathogenesis of ischemic stroke is complex, and PI3K/Akt signaling considered to play a crucial role in it. pathway regulates inflammation, oxidative stress, apoptosis, autophagy, vascular endothelial homeostasis after cerebral ischemia; therefore, drug research targeting the has become focus scientists. In this review, we analyzed reports antiischemic drugs past two decades. Because rich sources natural products, increasing studies have explored value compounds, including Flavonoids, Quinones, Alkaloids, Phenylpropanoids, Phenols, Saponins, Terpenoids, alleviating neurological impairment achieved satisfactory results. Herbal extracts medicinal formulas been applied treatment for thousands years East Asian countries. These precious clinical experiences provide new avenue drugs. Finally, summarize discuss characteristics shortcomings current put forward prospects further in‐depth exploration.
Language: Английский
Citations
17
Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 209, P. 110912 - 110912
Published: Feb. 27, 2024
Microglia activation and oligodendrocyte maturation are critical for remyelination after cerebral ischemia. Studies have shown that enriched environment (EE) can effectively alleviate stroke-induced neurological deficits. However, little is known about the mechanism associated with glial cells underlying neuroprotection of EE. Therefore, this study focuses on investigating effect EE activated microglia polarization as well oligodendrogenesis in progress following
Language: Английский
Citations
6
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0303213 - e0303213
Published: May 16, 2024
Ischemic stroke causes a lack of oxygen and glucose supply to brain, eventually leads severe neurological disorders. Retinoic acid is major metabolic product vitamin A has various biological effects. The PI3K-Akt signaling pathway an important survival in brain. Phosphorylated Akt regulating apoptosis. We examined whether retinoic neuroprotective effects model by its downstream protein, Bad. Moreover, we investigated the relationship between Bcl-2 family protein interactions. Animals were intraperitoneally administered vehicle or (5 mg/kg) for four days before surgery ischemic was induced middle cerebral artery occlusion (MCAO) surgery. Neurobehavioral tests performed 24 h after MCAO cortical tissues collected. Cresyl violet staining TUNEL histochemistry performed, Western blot immunoprecipitation analysis elucidate expression proteins. reduced deficits histopathological changes, decreased number TUNEL-positive cells, alleviated reduction phospho-PDK1, phospho-Akt, phospho-Bad caused damage. Immunoprecipitation showed that damage interaction 14-3-3, which attenuated acid. Furthermore, mitigated increase Bcl-2/Bad Bcl-xL/Bad binding levels Bcl-2/Bax Bcl-xL/Bax MCAO-induced caspase-3 cleaved expression. demonstrate prevented apoptosis against ischemia through phosphorylation Bad, maintenance 14-3-3 binding, regulation .
Language: Английский
Citations
6
Molecules, Journal Year: 2022, Volume and Issue: 27(22), P. 7963 - 7963
Published: Nov. 17, 2022
Ischemic stroke (IS) is an acute cerebrovascular disease caused by sudden arterial occlusion, which characterized a high morbidity, mortality, and disability rate. It one of the most important causes nervous system morbidity mortality in world. In recent years, search for new medicine treatment IS has become attractive research focus. Due to extremely limited time window traditional treatment, some side effects may occur, accompanied occurrence adverse reactions, frequency exploration with natural significantly increased. Phosphatidylinositol-3-kinase/Protein kinase B (PI3K/Akt) signaling pathway classical cell metabolism, growth, apoptosis, other physiological activities. There considerable on that treats various diseases through this pathway. This review focuses how medicines (including herbs insects) regulate pathophysiological processes such as inflammation, oxidative stress, autophagy PI3K/Akt pathway, role it plays improving IS. We found many kinds herbal insect can alleviate damage Moreover, prescription after their combination also achieve certain results. Therefore, provides candidate category development
Language: Английский
Citations
26
Oxidative Medicine and Cellular Longevity, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 24
Published: Feb. 6, 2023
Cardiovascular diseases (CVDs) are a set of heart and blood vessel disorders that include coronary disease (CHD), rheumatic disease, other conditions. Traditional Chinese Medicine (TCM) has definite effects on CVDs due to its multitarget multicomponent properties, which gradually gaining national attention. Tanshinones, the major active chemical compounds extracted from Salvia miltiorrhiza, exhibit beneficial improvement multiple diseases, especially CVDs. At level biological activities, they play significant roles, including anti-inflammation, anti-oxidation, anti-apoptosis anti-necroptosis, anti-hypertrophy, vasodilation, angiogenesis, combat against proliferation migration smooth muscle cells (SMCs), as well anti-myocardial fibrosis ventricular remodeling, all effective strategies in preventing treating Additionally, at cellular level, Tanshinones produce marked cardiomyocytes, macrophages, endothelia, SMCs, fibroblasts myocardia. In this review, we have summarized brief overview structures pharmacological CVD treatment expound different properties various cell types
Language: Английский
Citations
16