Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

Diseases, Journal Year: 2024, Volume and Issue: 12(5), P. 95 - 95

Published: May 6, 2024

Long COVID affects both children and adults, including subjects who experienced severe, mild, or even asymptomatic SARS-CoV-2 infection. We have provided a comprehensive overview of the incidence, clinical characteristics, risk factors, outcomes persistent COVID-19 symptoms in encompassing vulnerable populations, such as pregnant women oncological patients. Our objective is to emphasize critical significance adopting an integrated approach for early detection appropriate management long COVID. The incidence severity can significant impact on quality life patients course disease case pre-existing pathologies. Particularly, fragile patients, presence PASC related significantly worse survival, independent from vulnerabilities treatment. It important try achieve recognition management. Various mechanisms are implicated, resulting wide range presentations. Understanding specific factors involved crucial tailoring effective interventions support strategies. Management approaches involve biopsychosocial assessments treatment comorbidities, autonomic dysfunction, well multidisciplinary rehabilitation. overall one gradual improvement, with recovery observed majority, though not all, As research long-COVID continues evolve, ongoing studies likely shed more light intricate relationship between chronic diseases, status, cardiovascular psychiatric disorders, effects This information could guide healthcare providers, researchers, policymakers developing targeted interventions.

Language: Английский

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Diagnostic delays in systemic vasculitides

Rheumatology International, Journal Year: 2024, Volume and Issue: 44(6), P. 1003 - 1011

Published: April 8, 2024

Language: Английский

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Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 19, 2024

The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented concentration of economic and research efforts to generate knowledge at unequalled speed on deregulated interferon type I signalling nuclear factor kappa light chain enhancer in B-cells (NF-κB)-driven interleukin (IL)-1β, IL-6, IL-18 secretion causing cytokine storms. translation the how resulting systemic inflammation can lead life-threatening complications into novel treatments vaccine technologies is underway. Nevertheless, previously existing role cytoplasmatic or circulating self-DNA as a pro-inflammatory damage-associated molecular pattern (DAMP) was largely ignored. Pathologies reported ‘ de novo ’ for patients infected with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 be outcomes self-DNA-driven fact had been linked earlier different contexts, e.g., infection Human Immunodeficiency Virus (HIV)-1, sterile inflammation, autoimmune diseases. highlight particularly synergies other DAMPs render immunogenic properties normally non-immunogenic extracellular self-DNA, discuss shared features gp41 unit HIV-1 envelope protein SARS-CoV 2 Spike that enable SARS-CoV-2 interact cell membranes, trigger syncytia formation, inflict damage their host’s DNA, – likely own benefit. These similarities motivate speculations similar mechanisms those driven by explain inflammatory contributes some most frequent adverse events after vaccination BNT162b2 mRNA (Pfizer/BioNTech) mRNA-1273 (Moderna) vaccine, i.e., myocarditis, herpes zoster, rheumatoid arthritis, nephritis hepatitis, new-onset lupus erythematosus, flare-ups psoriasis lupus. hope wider application lessons learned from experiences COVID-19 new vaccines combat future non-COVID-19

Language: Английский

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Cutaneous small vessel vasculitis in the COVID-19 era: a systematic review

Skin Health and Disease, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract Background Dermatological adverse effects may occur after COVID-19 infection or vaccine administration. Since the beginning of pandemic, several case reports and systematic reviews have been published on vasculitis associated with both vaccination. Fever, malaise, urticaria, rash are common symptoms COVID-19. These can also as reactions to vaccines. However, occurrence serious autoimmune due its is rare. Cutaneous small vessel (CSVV) an disorder that manifests palpable purpura petechiae involving extremities. It results from neutrophilic inflammation within around dermal vessels usually self-limited. Objective We provide a thorough review CSVV occurring in era. Methods followed PRISMA 2020 checklist for review, searching PubMed, Google Scholar, Cochrane, Embase. included reports, series, correspondence articles, letters editor written English. Characteristics each were then summarized analyzed. Results 39 cases our – 27 12 infection. Mean age onset was similar, but mean time sooner vaccination group. Common treatments systemic steroids, almost all patients experienced complete recovery exception few cohort. Conclusion While most self-limiting resolve no long-term sequalae, more severe appears be rather than

Language: Английский

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The impact of COVID-19 on autoimmune diseases

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Fulminant Leukocytoclastic Vasculitis with Gangrene Necessitating Bilateral Below-knee Amputation in a Patient with Mild COVID-19 Infection: An Atypical Presentation

IJVES Case Reports, Journal Year: 2025, Volume and Issue: 3(1), P. 29 - 33

Published: Jan. 1, 2025

Covid-19, caused by SARS-CoV-2, is known for its diverse systemic effects, though rheumatological and cutaneous manifestations are relatively uncommon. We report a striking case of middle-aged Caucasian woman who developed diffuse, bilateral rash that progressed to gangrenous lesions. Despite testing positive she exhibited no respiratory symptoms. After excluding thromboembolic events other vasculitides, skin biopsy confirmed leukocytoclastic vasculitis, leading diagnosis COVID-19-associated vasculitis. The extensive progression ultimately required below-knee amputation, despite medical management. While mild vasculitic presentations have been observed in COVID-19 patients, such severe lesions extremely rare. This underscores the potential devastating complications SARS-CoV-2 infections, highlighting need heightened awareness further research into pathogenic mechanisms COVID-19-related vasculopathies.

Language: Английский

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Teledermatology for Common Inflammatory Skin Conditions: The Medicine of the Future?

Life, Journal Year: 2023, Volume and Issue: 13(4), P. 1037 - 1037

Published: April 18, 2023

Background: The COVID-19 pandemic period revolutionized daily clinical practice. Several strategies were adopted by clinicians to avoid reducing treatment for diseases without the risk of spreading infection. Among strategies, telemedicine played a key role. In this scenario, several tools used, including e-mails, phone calls, video support groups, and messages. Fortunately, seems be at an end. However, use teledermatology appears excellent strategy future as well. Indeed, patients may benefit from teledermatology. Objective: manuscript, we aim investigate in dermatological field point out how tool become mainstay medicine. Only with common inflammatory skin conditions have been reported herein. Materials Methods: Investigated manuscripts included metanalyses, reviews, letters editor, real-life studies, case series, reports. Manuscripts identified, screened, extracted relevant data following PRISMA (preferred reporting items systematic reviews meta-analyses) guidelines. Results: A total 121 records identified analyzed databases. only 110 articles assessed eligibility. Finally, 92 selected end literature research our review. Conclusions: Teledermatology should considered viable option dermatologist future. We believe that has strengthened service, will allow ever better development Guidelines regarding are required well additional improvements

Language: Английский

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Immunogenicity, Effectiveness, and Safety of COVID-19 Vaccines among Patients with Immune-Mediated Dermatological Diseases: A Systematic Review and Meta-analysis

Acta Dermato Venereologica, Journal Year: 2024, Volume and Issue: 104, P. adv40009 - adv40009

Published: May 2, 2024

Immunocompromised individuals, primarily attributable to using immunosuppressants, face heightened COVID-19 risks. Despite the proven efficacy of vaccines, their impact on patients with immune-mediated dermatological diseases remains unclear. This study aims thoroughly examine vaccine immunogenicity, effectiveness, and safety in disease patients. Clinical studies adults that compared vaccinated healthy controls or unvaccinated terms infection, adverse events, exacerbation were searched via electronic databases. Seventeen (1,348,690 participants) included. Seroconversion rates between not different. However, among individuals aged ≤55 years, had lower mean anti-SARS-CoV-2 IgG levels. Immunosuppressed also titres less likely achieve T-cell response. In safety, risk events was higher atopic dermatitis patients, but those psoriasis a reduced risk. Additionally, immunosuppressed fewer events. Vaccinated infection than controls; however, may be induced. conclusion, showed response our meta-analysis, yet vaccination remained effective against well tolerated.

Language: Английский

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Herpes Zoster and COVID-19 Vaccination: A Narrative Review

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2023, Volume and Issue: Volume 16, P. 3323 - 3331

Published: Nov. 1, 2023

Abstract: COVID-19 was a worldwide emergency, leading to global health crisis, which completely revolutionized every aspect of human life. Several strategies were adopted limit the spreading infection such as testing and contact tracing, quarantine isolation, use face mask, social distancing, lockdowns, travel restrictions, etc. Of these, vaccines most important measures reduce transmission virus severity infection, in order overcome pandemic. Fortunately, vaccination campaign success, showing be efficient controlling preventing COVID-19, reducing risk disease progression, hospitalization, mortality. Monitoring addressing vaccine-related adverse events have been essential for maintaining public confidence. Indeed, with increasing number administered, various cutaneous reactions reported, making dermatologists key players their recognition treatment. Particularly, several diseases findings reported. note, also viral reactivations described following vaccination. Among varicella zoster (VZV) reactivation has collected. Globally, an early diagnosis accurate treatment herpes (HZ) is mandatory possible complications. In this context, we conducted review current literature investigating cases HZ aim understanding causal correlation underlying pathogenetic mechanisms offer clinicians wide perspective on VZV vaccines. Keywords: vaccination, zoster, safety

Language: Английский

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New Onset of Giant Cell Arteritis following ChAdOx1-S (Vaxevria®) Vaccine Administration

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 434 - 434

Published: Feb. 13, 2023

We report a 78-year-old man presenting with persistent headaches in vertex and temporo-parietal area; fatigue, worsening after walking; jaw claudication; scotomas; pharyngodynia; dry cough the second dose of SARS-CoV-2 vaccine (ChAdOx1-S) administration. Laboratory findings showed an elevated C-reactive protein level FDG-CT PET evidence active large vessel vasculitis diffuse abnormal artery uptake. Under suspicion vasculitis, temporal arteries biopsy was performed; histopathologic demonstrated transmural inflammatory infiltrate giant cells, compatible cell arteritis. Although overall incidence vaccine-triggered autoimmunity is low, rheumatologists worldwide should be aware autoimmune diseases as new potential adverse event vaccines.

Language: Английский

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