Impact of serum lipid on recurrence of uterine fibroids: a single center retrospective study DOI Creative Commons
Yimin Ma,

Jingjing Weng,

Yingying Zhu

et al.

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 31, 2024

We aimed to analyze the correlation between serum lipid levels [total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), high (HDL-C)] and recurrence after uterine fibroids (UF) resection, explore predictive value of in determining myomectomy. In this retrospective cohort study, 323 patients undergoing first myomectomy who came from Li Huili Hospital, Ningbo Medical Center December 2019 January 2023 were included. The primary endpoint was UF within 12 months following surgery. Univariate multivariate logistic regression analyses adopted evaluate association four parameters risk recurrence. All included randomly assigned training group for nomogram development testing validation, with a ratio 7:3. Receiver operator characteristic, calibration curves, decision curve analysis used assess predicting performance constructed nomograms. Totally, 98 developed Multivariate indicated that TC [odds (OR) = 9.98, 95% confidence interval (CI): 4.28–23.30], LDL-C (OR 11.31, CI: 4.66–27.47) HDL-C 2.37, 1.21–4.64) associated risk. TG level did not statistical significance (P > 0.05). Four online prediction nomograms by integrating clinical features (TC-model, TG-model, LDL-C-model HDL-C-model). Through verification, these models may have good This study validated These can provide individual assessment

Language: Английский

Systemic immune-inflammation index mediates the association between abdominal obesity and serum klotho levels DOI Creative Commons
Chen-Chun Chen, Peng Tang, Wei Zhu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 4, 2025

The weight-adjusted waist index (WWI) has emerged as a reliable indicator of abdominal obesity. α-Klotho, transmembrane protein, functions suppressor aging. However, the relationship between these two factors remains underexplored. This study aims to investigate association WWI and serum α-Klotho levels in middle-aged elderly Americans, with focus on exploring potential mediating role systemic immune inflammation (SII). A cross-sectional was conducted using data from 6997 Americans participating National Health Nutrition Examination Surveys (NHANES) 2011 2016. Multiple linear regression analysis employed assess concentrations. Additionally, mediation performed effect SII relationships. Our revealed significant negative correlation survey-weighted multiple models (adjusted percent change: -7.79; 95% CI: -10.15, -5.37). Mediation demonstrated that partially mediated by -0.88; -1.24, -0.45), proportion amounting 11.6%. Further age-stratified results showed more pronounced among individuals aged ≥ 60 years, exhibiting 26.3%, contrast 4.2% for those < years. findings suggest is inversely associated concentrations this SII, especially older people.

Language: Английский

Citations

0
Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube DOI Creative Commons
Ian Beddows, Svetlana Djirackor, Dalia K. Omran

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Language: Английский

Citations

0
Exploring blood lipids-immunity associations following HBV vaccination: evidence from a large cross-sectional study DOI Creative Commons
Qian Yang,

Benhua Li,

Tiankuo Luan

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: March 8, 2024

Introduction Serological responses following hepatitis B vaccination are crucial for preventing (HBV). However, the potential relationship between serum lipid levels and immunity from HBV remains poorly understood. Methods In this study, we conducted an analysis of National Health Nutrition Examination Survey (NHANES) data spanning 2003 to 2016. Multivariable weighted logistic regression models, generalized linear analysis, stratified smooth curve fitting, segmentation effect sensitivity were utilized assess relationships. Results After adjusting relevant covariates, observed that low high-density lipoprotein cholesterol (HDL) independently linked a significantly lower seroprotective rate. Compared HDL ≥ 60 mg/dL, odds ratios (ORs) individuals with borderline (40-59 mg/dL men, 50-59 women) (&lt; 40 &lt; 50 0.83 (95% CI 0.69-0.99) 0.65 0.56-0.78), respectively. This association was particularly pronounced in aged or older. Conversely, higher triglyceride (TG/HDL) ratio (OR, 0.90; 95% CI, 0.84-0.98), total (Chol/HDL) 0.77; 0.64-0.92), low-density (LDL/HDL) 0.85; 0.76-0.96) associated decreased likelihood seroprotection. Conclusion study suggests may play role modulating immune response vaccination.

Language: Английский

Citations

1
Obesity Contributes to Transformation of Myometrial Stem-Cell Niche to Leiomyoma via Inducing Oxidative Stress, DNA Damage, Proliferation, and Extracellular Matrix Deposition DOI Open Access
Sadia Afrin, Gregory W. Kirschen, Mostafa A. Borahay

et al.

Genes, Journal Year: 2023, Volume and Issue: 14(8), P. 1625 - 1625

Published: Aug. 15, 2023

Leiomyomas (fibroids) are monoclonal tumors in which myometrial stem cells (MSCs) turn tumorigenic after mutation, abnormal methylation, or aberrant signaling. Several factors contribute to metabolic dysfunction obesity, including cellular proliferation, oxidative stress, and DNA damage. The present study aims determine how adipocytes adipocyte-secreted affect changes MSCs a manner that promotes the growth of uterine leiomyomas. Myometrial were isolated from uteri patients by fluorescence-activated cell sorting (FACS) using CD44/Stro1 antibodies. Enzyme-linked immunosorbent assay (ELISA), Western blot, immunocytochemistry assays performed on human (SW872) co-cultured with treated leptin adiponectin examine effects extracellular matrix (ECM) deposition, damage, Co-culture SW872 increased MSC proliferation compared culture alone, according 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) results. expressions PCNA COL1A significantly co-culture. In addition, expression these markers was treatment decreased MSCs. Wnt/β-catenin TGF-β/SMAD signaling pathways promote ECM deposition Wnt4, β-catenin, TGFβ3, pSMAD2/3 when adipocytes. We found co-culture resulted NOX4 expression, reactive oxygen species production, γ-H2AX expression. Leptin acts binding its receptor (LEP-R), leading signal transduction, resulting transcription genes involved angiogenesis, glycolysis. MSCs, LEP-R, pSTAT3/STAT3, pERK1/2/ERK/12. Based above results, we suggest obesity may mediate initiation tumorigenesis,

Language: Английский

Citations

3
ASSOCIAÇÃO ENTRE PRODUTO DE ACUMULAÇÃO LIPÍDICA OU LAP (TG/CA) E RAZÃO NEUTRÓFILO – LINFÓCITO (NLR) DOI Open Access

Williane Thamires dos Santos,

José de Bessa

Anais do ... Seminário de Iniciação Científica/Anais Seminário de Iniciação Científica, Journal Year: 2024, Volume and Issue: 27

Published: June 18, 2024

O Produto da Acumulação Lipídica (LAP) tem sido utilizado como um índice de baixo custo, fácil utilização e grande precisão para estimar o risco cardiovascular a mortalidade diversas causas (Kahn Valdez, 2003). Esse combina parâmetros antropométricos (circunferência cintura, CC) bioquímicos (triglicerídeos jejum, TG), sendo biomarcador emergente acúmulo central lipídeos relacionado ao diabetes mellitus, síndrome metabólica (SM), doença (Raposo et al., 2018).

Citations

0
LIPID-LADEN UTERUS: INVESTIGATING UTERINE FIBROIDS AND LIPID ASSOCIATION DOI

Sandeepa Kn,

Shilpa S. Shetty,

Prasanna Kumar Shetty

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155772 - 155772

Published: Dec. 15, 2024

Language: Английский

Citations

0
Genetic association of lipid and lipid-lowing drug targets with uterine fibroids DOI Creative Commons
Mei Wu,

Qiannan Lin,

Siyu Li

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41539 - e41539

Published: Dec. 27, 2024

Observational studies suggest that blood lipids are a risk factor for uterine fibroids (UFs) and lipid-lowering drugs beneficial the treatment prevention of UF; however, conclusions inconsistent. We aimed to determine causal effects on UFs using Mendelian randomization (MR). Genetic variants from genome-wide association (GWAS) lipid traits in genes encoding drug targets were extracted, two independent UF GWAS set as outcome. Their related estimated inverse variance weighted method. The MR analysis revealed high density lipoprotein cholesterol (HDL-C, OR = 0.88, 95 % CI: 0.83-0.93, P 3.58E-6) triglycerides (TG, 1.14, 1.07-1.21, 6.83E-5) protective factors UF, respectively. Drug-targeted results indicated genetically predicted inhibition cholesteryl ester transfer protein (CETP) was associated with lower (OR 0.95, 0.92-0.98, 7.83E-4), well reduced levels or other UF-associated clinical traits, including estradiol level, excessive menstruation, abdominal pelvic pain, myomectomy, miscarriage. Our study provides evidence HDL-C TG causally risk. Genetically proxied CETP may have effect against which warrants further investigation.

Language: Английский

Citations

0
Impact of serum lipid on recurrence of uterine fibroids: a single center retrospective study DOI Creative Commons
Yimin Ma,

Jingjing Weng,

Yingying Zhu

et al.

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 31, 2024

We aimed to analyze the correlation between serum lipid levels [total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), high (HDL-C)] and recurrence after uterine fibroids (UF) resection, explore predictive value of in determining myomectomy. In this retrospective cohort study, 323 patients undergoing first myomectomy who came from Li Huili Hospital, Ningbo Medical Center December 2019 January 2023 were included. The primary endpoint was UF within 12 months following surgery. Univariate multivariate logistic regression analyses adopted evaluate association four parameters risk recurrence. All included randomly assigned training group for nomogram development testing validation, with a ratio 7:3. Receiver operator characteristic, calibration curves, decision curve analysis used assess predicting performance constructed nomograms. Totally, 98 developed Multivariate indicated that TC [odds (OR) = 9.98, 95% confidence interval (CI): 4.28–23.30], LDL-C (OR 11.31, CI: 4.66–27.47) HDL-C 2.37, 1.21–4.64) associated risk. TG level did not statistical significance (P > 0.05). Four online prediction nomograms by integrating clinical features (TC-model, TG-model, LDL-C-model HDL-C-model). Through verification, these models may have good This study validated These can provide individual assessment

Language: Английский

Citations

0