Journal of Tropical Medicine,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Objectives:
After
the
global
impact
of
COVID‐19
pandemic,
concerns
over
virus
transmission
have
risen.
A
state
health
emergency
was
declared
in
2022
due
to
Clade
2
monkeypox
(MPOX)
virus.
In
August
2024,
another
by
World
Health
Organization
(WHO)
because
widespread
1b,
which
caused
a
more
severe
and
lethal
disease.
This
review
synthesizes
current
MPOX
knowledge
assist
policymakers,
clinicians,
researchers
developing
effective
diagnostics,
therapeutic
interventions,
vaccination
strategies,
outbreak
management.
Methods:
systematic
study
searched
for
articles
on
epidemiology,
virology,
clinical
features,
routes,
available
drugs
vaccines,
new
artificial
intelligence
(AI)
applications
diagnosis
drug
discovery.
Results:
is
200–250‐nm,
double‐stranded
DNA
(ds‐DNA)
that
causes
smallpox‐like
skin
lesions.
Tecovirimat
primary
cases,
especially
people
with
suppressed
immune
systems.
Smallpox
vaccines
can
help
prevent
infection
genetic
similarities
between
smallpox
viruses.
AI‐based
models
medical
teams
promptly
diagnosing
lesions,
improving
decision‐making
treatment.
Conclusion:
highlights
importance
using
traditional
public
alongside
modern
AI
manage
outbreaks
effectively.
It
shows
we
need
strong
policies,
focused
ongoing
research
how
control
infectious
diseases.
Revista Contemporânea,
Journal Year:
2025,
Volume and Issue:
5(3), P. e7755 - e7755
Published: March 21, 2025
A
monkeypox
é
uma
zoonose
viral
causada
pelo
vírus
Monkeypox
(MPXV),
pertencente
ao
gênero
Orthopoxvirus.
Desde
sua
primeira
identificação
em
humanos
1970,
a
doença
permaneceu
endêmica
partes
da
África,
mas,
recentemente,
surtos
globais
regiões
não
endêmicas
levantaram
preocupações
sobre
disseminação.
O
pode
ser
transmitido
contato
direto
com
fluidos
corporais,
lesões
cutâneas
ou
secreções
respiratórias,
além
do
sexual
ter
sido
destacado
como
fator
relevante
nos
recentes.
Clinicamente,
se
manifesta
febre,
linfadenopatia
e
erupções
cutâneas,
podendo
evoluir
para
complicações
graves
grupos
vulneráveis.
diagnóstico
padrão
feito
por
RT-PCR,
mas
desafios
subnotificação
o
acesso
desigual
testes
dificultam
controle
epidemiológico.
tratamento
baseado
no
manejo
dos
sintomas,
embora
antivirais
tecovirimat
tenham
utilizados
eficácia
moderada.
vacinação
contra
varíola
oferece
proteção
parcial,
esforços
ampliar
vacinas
específicas
são
fundamentais.
prevenção
exigem
vigilância
epidemiológica
eficaz,
cooperação
internacional
investimentos
novas
estratégias
terapêuticas
diagnósticas.
Viruses,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1620 - 1620
Published: Oct. 16, 2024
According
to
the
WHO,
more
than
90,000
cases
of
mpox
have
been
reported
since
2022
worldwide
outbreak,
which
resulted
in
167
deaths,
while
a
new
outbreak
Africa
2023
has
over
18,000
and
617
deaths.
Mpox
is
zoonosis
caused
by
monkeypox
virus,
double-stranded
DNA
virus
belonging
Orthopoxvirus
genus,
causes
smallpox-like
illness.
Until
2022,
were
predominately
located
West
Central
Africa,
with
only
sporadic
outbreaks
other
parts
world.
During
primary
mode
transmission
was
sexual
contact
among
men
who
sex
men.
The
changing
epidemiology
disease
phenotypes
populations
at
risk,
disproportionally
affecting
people
live
HIV.
Commonly
presenting
as
mild,
self-limiting
illness,
can
cause
severe
protracted
HIV
CD4
count
<
200
cell/mm
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 20, 2024
Monkeypox
(Mpox)
is
a
rare
viral
disease
that
presents
considerable
challenges
in
healthcare
settings,
necessitating
enhanced
nursing
care
for
effective
management.
This
review
thoroughly
explores
key
aspects
related
to
improving
Mpox.
It
commences
by
examining
the
background
information
on
Mpox,
encompassing
its
etiology,
epidemiology,
and
modes
of
transmission.
The
differential
diagnosis
Mpox
investigated,
elucidating
clinical
presentation,
symptoms,
diagnostic
methods
differentiate
it
from
similar
conditions.
Prevention
control
measures
at
both
public
health
levels
are
scrutinized,
including
surveillance
reporting,
contact
tracing,
isolation,
vaccination
programs.
In
infection
prevention
strategies,
such
as
proper
utilization
personal
protective
equipment,
hand
hygiene,
environmental
management,
discussed.
Furthermore,
therapeutic
interventions
symptomatic
antiviral
therapy,
supportive
care,
outlined,
with
specific
emphasis
pain
fever
control,
psychosocial
support.
Nursing
strategies
encompass
patient
assessment
monitoring,
support,
education.
encountered
enhancing
acknowledged,
along
research
gaps
areas
further
investigation.
Finally,
innovations
practice
improved
technology
integration
simulation-based
training,
explored.
Enhancing
crucial
positive
outcomes,
reducing
transmission
risks,
promoting
overall
well-being.
By
addressing
unique
challenges,
conducting
research,
embracing
innovative
practices,
professionals,
particularly
nurses,
can
provide
optimal
contribute
better
management
cases.
Viral
adhesion
to
host
cells
is
a
critical
step
in
infection
for
many
viruses,
including
monkeypox
virus
(MPXV).
In
MPXV,
the
H3
protein
mediates
viral
through
its
interaction
with
heparan
sulfate
(HS),
yet
structural
details
of
this
have
remained
elusive.
Using
AI-based
prediction
tools
and
molecular
dynamics
(MD)
simulations,
we
identified
novel,
positively
charged
α-helical
domain
that
essential
HS
binding.
This
conserved
domain,
found
across
orthopoxviruses
,
was
experimentally
validated
shown
be
adhesion,
making
it
an
ideal
target
antiviral
drug
development.
Targeting
designed
inhibitor,
which
disrupted
H3-HS
interaction,
inhibited
vitro
replication
vivo,
offering
promising
candidate.
Our
findings
reveal
novel
therapeutic
demonstrating
potential
combination
AI-driven
methods
MD
simulations
accelerate
discovery.
Journal of Tropical Medicine,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Objectives:
After
the
global
impact
of
COVID‐19
pandemic,
concerns
over
virus
transmission
have
risen.
A
state
health
emergency
was
declared
in
2022
due
to
Clade
2
monkeypox
(MPOX)
virus.
In
August
2024,
another
by
World
Health
Organization
(WHO)
because
widespread
1b,
which
caused
a
more
severe
and
lethal
disease.
This
review
synthesizes
current
MPOX
knowledge
assist
policymakers,
clinicians,
researchers
developing
effective
diagnostics,
therapeutic
interventions,
vaccination
strategies,
outbreak
management.
Methods:
systematic
study
searched
for
articles
on
epidemiology,
virology,
clinical
features,
routes,
available
drugs
vaccines,
new
artificial
intelligence
(AI)
applications
diagnosis
drug
discovery.
Results:
is
200–250‐nm,
double‐stranded
DNA
(ds‐DNA)
that
causes
smallpox‐like
skin
lesions.
Tecovirimat
primary
cases,
especially
people
with
suppressed
immune
systems.
Smallpox
vaccines
can
help
prevent
infection
genetic
similarities
between
smallpox
viruses.
AI‐based
models
medical
teams
promptly
diagnosing
lesions,
improving
decision‐making
treatment.
Conclusion:
highlights
importance
using
traditional
public
alongside
modern
AI
manage
outbreaks
effectively.
It
shows
we
need
strong
policies,
focused
ongoing
research
how
control
infectious
diseases.
