Trajectories of functional and structural myocardial parameters in post-COVID-19 syndrome—insights from mid-term follow-up by cardiovascular magnetic resonance DOI Creative Commons
Jan Gröschel,

Leonhard Grassow,

Phillip van Dijck

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: April 2, 2024

Introduction Myocardial tissue alterations in patients with post-Coronavirus disease 2019 syndrome (PCS) are often subtle and mild. Reports vary the prevalence of non-ischemic ischemic injuries as well extent ongoing myocardial inflammation. The exact relevance these is not fully understood. This study aimed at describing trajectories PCS by mid-term follow-up cardiovascular magnetic resonance (CMR). Methods entails a retrospective analysis symptomatic referred for CMR between August 2020 May 2023 due to mildly affected or reduced left right ventricular function (LV RV, respectively) structural alterations, e.g., focal diffuse fibrosis, on baseline scans. Follow-up protocol consisted cine images full coverage native T1 T2 mapping. Baseline scans were compared using t -tests Wilcoxon tests. Post-hoc was carried out subgroup based change LV stroke volume (SV) Results In total, 43 [median age (interquartile range) 46 (37–56) years, 33 women] received follow-ups 347 (167–651) days after initial diagnosis. A decrease symptoms recorded ( p < 0.03) 23 being asymptomatic [symptomatic 43/43 (100%) vs. 21/43 (49%), 0.001]. Functional improvement noted LV-SV [83.3 (72.7–95.0) 84.0 (77.0–100.3) ml; = 0.045], global radial [25.3% (23.4%–27.9%) 27.4% (24.4%–33.1%); 0.001], circumferential strains [−16.5% (−17.5% −15.6%) −17.2% (−19.5% −16.1%); 17 had an >10% (5 12 increase), LV-SV, RV-SV, longitudinal strain discriminatory variables 0.01, 0.02, 0.04, respectively). T1- T2-analysis revealed no changes, remaining within normal limits. Conclusion Symptomatic load blood pressures decreased follow-up. did detect significant changes parameters; however, volumetric, specifically deformation indexes improved during

Language: Английский

Value of 123I-MIBG SPECT for the assessment of dysautonomia in patients with long COVID DOI Creative Commons
Adriana Soares Xavier de Brito, Ana Inês Bronchtein, Eduardo B. Schaustz

et al.

IJC Heart & Vasculature, Journal Year: 2024, Volume and Issue: 52, P. 101413 - 101413

Published: April 26, 2024

Language: Английский

Citations

4
Assessment of Autonomic Nervous System Function in Patients with Chronic Fatigue Syndrome and Post-COVID-19 Syndrome Presenting with Recurrent Syncope DOI Open Access
Branislav Milovanović,

Nina Markovic,

Maša Petrović

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 811 - 811

Published: Jan. 26, 2025

Background/Objectives: Chronic fatigue syndrome and post-COVID-19 are associated with dysfunction of the autonomic nervous system, which may manifest as syncope orthostatic intolerance. This study aimed to compare system function in patients chronic unknown etiology those secondary using multiple diagnostic modalities, assess prevalence characteristics these populations. Methods: cross-sectional included 440 examined at Neurocardiological Laboratory Institute for Cardiovascular Diseases “Dedinje”. Patients were divided into three groups: (Group 1, n = 210), 2, 137), healthy controls 3, 91). Diagnostic modalities cardiovascular reflex tests, head-up tilt test, beat-to-beat analysis, 24 h Holter electrocardiogram monitoring, ambulatory blood pressure monitoring. Statistical analyses performed analysis variance, Tukey’s honestly significant difference Mann–Whitney U test. Results: Both groups demonstrated compared (p < 0.05), including reduced baroreceptor sensitivity impaired heart rate variability parameters. Syncope was high both groups, extreme observed 45–47% during exhibited greater increases test than 0.05). Conclusions: syndrome, irrespective etiology, exhibit a syncope. Post-COVID-19 demonstrates distinct hemodynamic patterns, suggesting unique pathophysiological mechanisms that warrant further investigation.

Language: Английский

Citations

0
A model-based spectral directional approach reveals the long-term impact of COVID-19 on cardiorespiratory control and baroreflex DOI Creative Commons
Beatrice Cairo, Francesca Gelpi, Vlasta Bari

et al.

BioMedical Engineering OnLine, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 3, 2025

Abstract Background Coronavirus disease 19 (COVID-19) patients might develop sequelae after apparent resolution of the infection. Autonomic dysfunction and baroreflex failure have been frequently reported. However, long-term effect COVID-19 on cardiorespiratory cardiovascular neural controls has not investigated with directional approaches able to open closed-loop relationship between physiological variables. Methods A model-based causal spectral approach, namely squared coherence (CK 2 ), was applied beat-to-beat variability series heart period (HP) systolic arterial pressure (SAP), respiratory signal (RESP) acquired at rest in supine position during active standing (STAND) survivors 9 months their hospital discharge. Patients were categorized according need ventilatory support hospitalization as individuals that had no continuous positive airway (noCPAP, n = 27), sub-intensive care unit (CPAP, 14) invasive mechanical ventilation intensive (IMV, 8). Results The expected decrease strength HP-RESP dynamic interactions well increase dependence HP SAP along STAND observed this result held regardless severity disease, noCPAP, CPAP IMV cohorts. Regardless experimental condition, causality markers did vary across groups either. Conclusions CK markers, association an orthostatic challenge, characterize impairment control long acute infection could be exploited monitor evolution

Language: Английский

Citations

0
Exaggerated blood pressure elevation in response to orthostatic challenge, a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization DOI
Antonio González-Hermosillo, Esteban Jorge‐Galarza,

Onasis Vicente Fermín

et al.

Autonomic Neuroscience, Journal Year: 2023, Volume and Issue: 247, P. 103094 - 103094

Published: April 22, 2023

Language: Английский

Citations

5
Trajectories of functional and structural myocardial parameters in post-COVID-19 syndrome—insights from mid-term follow-up by cardiovascular magnetic resonance DOI Creative Commons
Jan Gröschel,

Leonhard Grassow,

Phillip van Dijck

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: April 2, 2024

Introduction Myocardial tissue alterations in patients with post-Coronavirus disease 2019 syndrome (PCS) are often subtle and mild. Reports vary the prevalence of non-ischemic ischemic injuries as well extent ongoing myocardial inflammation. The exact relevance these is not fully understood. This study aimed at describing trajectories PCS by mid-term follow-up cardiovascular magnetic resonance (CMR). Methods entails a retrospective analysis symptomatic referred for CMR between August 2020 May 2023 due to mildly affected or reduced left right ventricular function (LV RV, respectively) structural alterations, e.g., focal diffuse fibrosis, on baseline scans. Follow-up protocol consisted cine images full coverage native T1 T2 mapping. Baseline scans were compared using t -tests Wilcoxon tests. Post-hoc was carried out subgroup based change LV stroke volume (SV) Results In total, 43 [median age (interquartile range) 46 (37–56) years, 33 women] received follow-ups 347 (167–651) days after initial diagnosis. A decrease symptoms recorded ( p &lt; 0.03) 23 being asymptomatic [symptomatic 43/43 (100%) vs. 21/43 (49%), 0.001]. Functional improvement noted LV-SV [83.3 (72.7–95.0) 84.0 (77.0–100.3) ml; = 0.045], global radial [25.3% (23.4%–27.9%) 27.4% (24.4%–33.1%); 0.001], circumferential strains [−16.5% (−17.5% −15.6%) −17.2% (−19.5% −16.1%); 17 had an &gt;10% (5 12 increase), LV-SV, RV-SV, longitudinal strain discriminatory variables 0.01, 0.02, 0.04, respectively). T1- T2-analysis revealed no changes, remaining within normal limits. Conclusion Symptomatic load blood pressures decreased follow-up. did detect significant changes parameters; however, volumetric, specifically deformation indexes improved during

Language: Английский

Citations

1