Identification of potential diagnostic biomarkers for hypertension via integrated analysis of gene expression and DNA methylation
Blood Pressure,
Journal Year:
2024,
Volume and Issue:
33(1)
Published: Aug. 1, 2024
Hypertension
refers
to
the
elevated
blood
pressure
(BP)
in
arteries,
with
a
BP
reading
of
140/90
mm
Hg
or
higher
adults.
Over
40%
>25-year-old
population
have
suffered
from
hypertension.
Thus,
this
study
aimed
find
novel
diagnostic
biomarkers
for
Language: Английский
Current insights in ultra-rare adenylosuccinate synthetase 1 myopathy – meeting report on the First Clinical and Scientific Conference. 3 June 2024, National Centre for Advancing Translational Science, Rockville, Maryland, the United States of America
Orphanet Journal of Rare Diseases,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Nov. 26, 2024
The
inaugural
Clinical
and
Scientific
Conference
on
Adenylosuccinate
Synthetase
1
(ADSS1)
myopathy
was
held
June
3,
2024,
at
the
National
Institutes
of
Health
(NIH)
Center
for
Advancing
Translational
Sciences
(NCATS)
in
Rockville,
Maryland,
USA.
ADSS1
is
an
ultra-rare,
inherited
neuromuscular
disease.
Features
geographical
patient
clusters
South
Korea,
Japan,
India
United
States
America
were
characterised
discussed.
Pre-clinical
animal
cell-based
models
discussed,
providing
unique
insight
into
disease
pathogenesis.
biochemical
pathogenesis
potential
therapeutic
targets
identified.
Potential
clinical
pre-clinical
biomarkers
An
consortium
established
a
roadmap
development
created.
Language: Английский
Epigenetic scores derived in saliva are associated with gestational age at birth
Clinical Epigenetics,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: June 29, 2024
Epigenetic
scores
(EpiScores),
reflecting
DNA
methylation
(DNAm)-based
surrogates
for
complex
traits,
have
been
developed
multiple
circulating
proteins.
EpiScores
pro-inflammatory
proteins,
such
as
C-reactive
protein
(DNAm
CRP),
are
associated
with
brain
health
and
cognition
in
adults
inflammatory
comorbidities
of
preterm
birth
neonates.
Social
disadvantage
can
become
embedded
child
development
through
inflammation,
deprivation
is
overrepresented
infants.
We
tested
the
hypotheses
that
socioeconomic
status
(SES)
alterations
a
set
enriched
inflammation-associated
Language: Английский