Angiopoietin-2 and endothelial damage associated with viral load in untreated people living with HIV DOI Creative Commons

Paulo Pacelli Bezerra Filizola Tôrres,

Gdayllon Cavalcante Meneses,

Lana Andrade Lucena Lima

et al.

International Journal of STD & AIDS, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

HIV infection is associated with various types of endothelial damage. Early and accurate diagnosis dysfunction may help prevent adverse outcomes. For the first time, this cross-sectional study aims to investigate effects increased viral load on damage nephrinuria in untreated people living HIV. People not treatment were included. Laboratory parameters, such as CD4 count collected. Participants divided into three groups according tertiles load: low, moderate high groups. Urinary nephrin, vascular cell adhesion molecule 1 (VCAM-1), angiopoietin-2 syndecan-1 quantified by sandwich ELISA assays kits. A total 49 patients examined. The group (3rd tertile) exhibited a greater frequency significantly higher levels (58 [48-93] vs 43 [38-65] ng/mL, p = .049) (2.58 [1.5-3.06] 1.34 [0.89-1.76] .035). Syndecan-1 positively correlated (rho 0.452, .006), while was 0.529, .001) inversely -0.493, .003). No significant associations found for VCAM-1 levels. Untreated elevated loads more pronounced inflammation, emphasizing critical importance early initiation antiretroviral mitigate these complications. However, study's findings should be interpreted caution due small sample size, which limit generalizability results. Future studies larger cohorts are needed confirm findings.

Language: Английский

Angiopoietin-2 and endothelial damage associated with viral load in untreated people living with HIV DOI Creative Commons

Paulo Pacelli Bezerra Filizola Tôrres,

Gdayllon Cavalcante Meneses,

Lana Andrade Lucena Lima

et al.

International Journal of STD & AIDS, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

HIV infection is associated with various types of endothelial damage. Early and accurate diagnosis dysfunction may help prevent adverse outcomes. For the first time, this cross-sectional study aims to investigate effects increased viral load on damage nephrinuria in untreated people living HIV. People not treatment were included. Laboratory parameters, such as CD4 count collected. Participants divided into three groups according tertiles load: low, moderate high groups. Urinary nephrin, vascular cell adhesion molecule 1 (VCAM-1), angiopoietin-2 syndecan-1 quantified by sandwich ELISA assays kits. A total 49 patients examined. The group (3rd tertile) exhibited a greater frequency significantly higher levels (58 [48-93] vs 43 [38-65] ng/mL, p = .049) (2.58 [1.5-3.06] 1.34 [0.89-1.76] .035). Syndecan-1 positively correlated (rho 0.452, .006), while was 0.529, .001) inversely -0.493, .003). No significant associations found for VCAM-1 levels. Untreated elevated loads more pronounced inflammation, emphasizing critical importance early initiation antiretroviral mitigate these complications. However, study's findings should be interpreted caution due small sample size, which limit generalizability results. Future studies larger cohorts are needed confirm findings.

Language: Английский

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