Eye, Journal Year: 2024, Volume and Issue: unknown
Published: June 11, 2024
American Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
3
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(12)
Published: Dec. 3, 2024
This review explores the intricate relationship between glaucoma and circadian rhythm disturbances. As a principal organ for photic signal reception transduction, eye plays pivotal role in coordinating body's rhythms through specialized retinal ganglion cells (RGCs), particularly intrinsically photosensitive RGCs (ipRGCs). These are critical transmitting light signals to suprachiasmatic nucleus (SCN), central clock that synchronizes physiological processes 24-hour light-dark cycle. The delves into body clock, highlighting importance of retino-hypothalamic tract conveying information from eyes SCN. It underscores melanopsin ipRGCs absorbing initiating biochemical reactions culminate synchronization SCN's firing patterns with external environment. Furthermore, discusses local within eye, such as those affecting photoreceptor sensitivity, corneal thickness, intraocular fluid outflow. emphasizes potential optical coherence tomography (OCT) studying structural losses associated disruption. Glaucomatous damage is identified cause disruption, mechanisms including oxidative stress, neuroinflammation, direct RGCs. consequences disruption complex, systemic rhythms, sleep patterns, mood, metabolism. Countermeasures, implications management, proposed focus on strategies improve health balanced melatonin timing, daylight exposure, chronotherapeutic approaches. calls further research elucidate linking develop effective interventions address this aspect disease.
Language: Английский
Citations
3
Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 3, 2025
This study aimed to investigate the relationship between sleep duration and myopia in school-age students, as well observe role of physical activity a mediating variable myopia. Using multistage stratified sampling, 26,020 students Jiangsu Province, ages 7-18, were selected for this cross-sectional survey. Each participant completed standardized interview which their asked about vision, level average hours per day over past month. Visual acuity examinations conducted by testing team's ophthalmology professionals they categorized into two groups based on pre-set criteria: myopic non-myopic. Sleep was classified 3 categories: <8 h/d, 8-10 >10 h/d. The Pearson's chi-square tests used examine differences incidence among participants. Binary multifactorial logistic regression adjusted potential confounding variables variety factors. effects analyzed using AMOS model. In study, higher females than males, it also increased with age. Those who slept h/d had greatest rate (85.69%) compared those for≥8 (p < 0.001). found be adversely correlated (sleep = h/d: OR 0.68, p 0.01; > 10 0.48, 0.01) after controlling confounders like gender, age, BMI-z score (Body Mass Index Score). Physical at high intensity not moderate protective factor against High-intensity acted mediator negative association (a, b, c' all 0.05). There is correlation that high-intensity mediates
Language: Английский
Citations
0
IP International Journal of Ocular Oncology and Oculoplasty, Journal Year: 2025, Volume and Issue: 10(4), P. 188 - 195
Published: Jan. 14, 2025
Biosensors are essential tools designed to monitor physiologically significant data for diverse applications, including environmental pollution detection, food safety, medication research, and disease diagnosis. The integration of microfluidics, nanotechnology, advanced electronics has significantly the development wearable implantable biosensors managing chronic diseases such as cancer, diabetes, glaucoma. Among these, glaucoma remains a leading cause visual impairment, predominantly driven by elevated intraocular pressure (IOP), with limited treatment effectiveness due challenges like suboptimal drug bioavailability therapeutic inefficiency. Despite advances, unmet needs in early diagnosis sustained management persist, demanding innovative solutions. Recent advancements nanotechnology offer transformative potential, addressing these enhancing both detection ocular diseases. This review explores cutting-edge developments nano-drug delivery systems continuous IOP monitoring technologies. Particular emphasis is placed on nanoparticle nanofiber-based contact lenses, which represent promising leap forward improving precision patient outcomes care. manuscript uniquely contributes synthesizing highlighting their potential bridge existing gaps management.
Language: Английский
Citations
0
Advances in genetics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of International Medical Research, Journal Year: 2025, Volume and Issue: 53(2)
Published: Feb. 1, 2025
Objective To investigate the causal effects of physical activity and sedentary traits on risk Age-related macular degeneration (AMD). Methods A two-sample Mendelian randomization (MR) analysis was used to relationship between AMD. We genome-wide association studies (GWAS) summary statistics from two publicly available biobank-scale cohorts: UK Biobank FinnGen. Physical data were self-reported by 703,901 participants behaviour gathered 159,606 FinnGen participants. Our primarily inverse variance weighted (IVW) method. Result Engaging in moderate-to-vigorous significantly reduced AMD with an odds ratio 0.77 (95% CI: 0.66–0.89). However, leisure screen time showed a slight but non-statistically significant upward trend. Sedentary at work, commuting no risk. Conclusions This study MR examine activity, behaviour, It offers genetic evidence suggesting that may protect against AMD, emphasizing significance lifestyle factors maintaining ocular health.
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 1, 2025
This study aimed to systematically evaluate the dose-response relationships between physical activity (PA), sedentary behavior(SB) (including near work [NW] and screen time [ST]), sleep duration (SD), myopia risk among children adolescents. Systematic review meta-analysis. We searched PubMed, EMBASE, Cochrane Library, Web of Science up November 19, 2024. Methodological quality was assessed using Joanna Briggs Institute (JBI) ROBINS-I tools. Random-effects meta-analyses were used estimate categorical continuous relationships. Subgroup analyses sensitivity performed explore heterogeneity sources test robustness. A total 45 observational studies (766,848 participants aged 5–19 years) included. Categorical showed that, compared with lowest exposure categories, higher PA levels (highest: OR = 0.77, 95% CI: 0.63–0.96; intermediate: 0.76, 0.63–0.93) longer SD 0.67, 0.48–0.92; 0.82, 0.73–0.92) significantly reduced risk. Conversely, NW 1.71, 1.28–2.27; 1.34, 1.19–1.50) ST 1.59, 1.14–2.22; 1.29, 1.12–1.49) associated increased In meta-analysis, a linear association observed PA, ST, myopia. Each additional hour per day by 12%, while each 31%. Nonlinear associations found NW, SD, Among adolescents, 1.5 2.5 h/day 25% 29%, respectively. Although myopia, this effect did not reach statistical significance at any level.Subgroup revealed that protective effects more evident in low- middle-income countries, smaller sample sizes, cross-sectional studies, risks related stronger low-income settings. No subgroup modified Increasing limiting effectively reduces The remains inconclusive, warranting further investigation.
Language: Английский
Citations
0
Life, Journal Year: 2025, Volume and Issue: 15(6), P. 857 - 857
Published: May 26, 2025
Diabetic retinopathy (DR) is a leading cause of vision loss in patients with diabetes. While medical treatments like retinal laser photocoagulation, anti-VEGF therapy, and vitrectomy are primary, complementary therapies gaining increasing attention. Based on the existing literature, healthy lifestyle, including balanced diet, stress management techniques, regular physical activity targeting DR, can help regulate blood sugar levels improve overall mental health to reduce complications. This article explores activities visual training methods related emphasizing therapies, even though some these practices currently not fully integrated into evidence-based ophthalmology. Low exercises aids make most their remaining vision, improving ability perform everyday tasks, reducing impact loss, promoting independence. There evidence that eye-related physiotherapy quality life for although selection bias cannot be excluded presented studies. Consistent promotes holistic health, should regularly monitored by ophthalmologists. review further helps integrative healthcare professionals offering appropriate rehabilitation purposes treatment ophthalmic diseases, particularly DR.
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Aug. 1, 2024
Background Myopia is a significant public health problem across the globe. This study aimed to examine regional disparity in prevalence and correlated factors of myopia children adolescents two typical regions, Gannan Tibetan Autonomous Prefecture (Gannan for short, residential area) Wuwei City (a Han Gansu Province, China, provide reference prevention control myopia. Methods The was cross-sectional China. A total 6,187 (Wuwei City: 3,266, Prefecture: 2,921) students were selected by stratified cluster sampling. Eye examinations questionnaires administered participants. defined as condition which spherical equivalent refractive error an eye less than or equal −0.50 D when ocular accommodation relaxed. χ 2 test multivariate logistic regression analysis used analyze Results rate 71.4%, had higher (77.5%) compared (64.6%) ( p < 0.001). results showed that girls (odds ratio OR ) = 1.325), junior 2.542), senior students( 4.605), distance between eyes book one foot 1.291), parents with (one, 2.437; two, 4.453) risks (all, 0.05). For Prefecture, 1.477), 1.537), daily time spent doing homework ≥2 h (OR 1.420), 1.205), mean continuous use (0.25–<0.5 h, 1.345, 0.5–<1 1.317, ≥1 1.313), average sleep duration <8 1.399), 1.852; 2.913) Conclusion at relatively high level Province. risk vary region.
Language: Английский
Citations
2
BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 25, 2024
The presence of sensory impairment among older age cohorts exerts a significant impact on both individuals and society generally. Although the dietary patterns health is vital across all stages life, there still paucity comprehensive research association between variety impairments.
Language: Английский
Citations
1