A Comprehensive Review of the Endometrial Receptivity Array in Euploid Embryo Transfer Cycles DOI Open Access

Medhavi Sharma,

Pankhuri Dubey,

Urmila Sunda

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

The Endometrial Receptivity Array (ERA) is a revolutionary molecular diagnostic tool that determines the optimal timing for embryo transfer by analyzing gene expression profile of endometrial tissue. This comprehensive review examines significance and application ERA in euploid cycles, where implantation embryos with correct number chromosomes critical achieving successful pregnancy outcomes. underscores its role enhancing rates reducing loss assessing evolution, methodology, clinical applications, efficacy, challenges associated ERA. Key findings highlight ERA's superior accuracy identifying window compared to traditional methods, resulting improved outcomes assisted reproductive technology (ART) cycles. Despite benefits, acknowledges such as cost, accessibility, need standardization. Recommendations practice emphasize integration into routine ART protocols, patient counseling, importance multidisciplinary collaboration. outlines promising prospects, including technological advancements make more cost-effective, development refined profiles, potential other emerging technologies. Further research directions include long-term studies on ERA-guided pregnancies exploring cases recurrent failure unexplained infertility. Overall, represents significant advancement medicine, offering personalized approach can significantly improve success transfers.

Language: Английский

Molecular and biological markers for assessing endometrial receptivity in infertile women: A narrative review DOI Creative Commons

Junfeng Li,

Hange Liu,

Justin Lim

et al.

Journal of International Medical Research, Journal Year: 2025, Volume and Issue: 53(4)

Published: April 1, 2025

Successful embryo implantation relies on quality, endometrial receptivity, and the synchronized development of both. In recent years, methods for assessing receptivity have considerably advanced, shifting from traditional imaging techniques to modern molecular biology approaches. The evaluation thickness, morphology, subendometrial blood flow, peristalsis before has become less prominent, whereas markers such as pinopodes, integrin αvβ3, its ligand osteopontin, homologous box gene A10 are widely used in clinical practice receptivity. To provide a comprehensive overview, this narrative review systematically searched PubMed Web Science studies assessment infertile women over past two decades, with focus both experimental research. This examined advancements morphological markers, receptivity–related genes, microbiota, other emerging indicators, emphasizing their potential optimizing improving success rates assisted reproductive technologies. Notably, array testing uterine microbiome analysis gained substantial attention personalized diagnosis treatment. aims scientific insights precise infertility diagnostics individualized treatment strategies while offering recommendations future research development.

Language: Английский

Citations

0
A Comprehensive Review of the Endometrial Receptivity Array in Euploid Embryo Transfer Cycles DOI Open Access

Medhavi Sharma,

Pankhuri Dubey,

Urmila Sunda

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

The Endometrial Receptivity Array (ERA) is a revolutionary molecular diagnostic tool that determines the optimal timing for embryo transfer by analyzing gene expression profile of endometrial tissue. This comprehensive review examines significance and application ERA in euploid cycles, where implantation embryos with correct number chromosomes critical achieving successful pregnancy outcomes. underscores its role enhancing rates reducing loss assessing evolution, methodology, clinical applications, efficacy, challenges associated ERA. Key findings highlight ERA's superior accuracy identifying window compared to traditional methods, resulting improved outcomes assisted reproductive technology (ART) cycles. Despite benefits, acknowledges such as cost, accessibility, need standardization. Recommendations practice emphasize integration into routine ART protocols, patient counseling, importance multidisciplinary collaboration. outlines promising prospects, including technological advancements make more cost-effective, development refined profiles, potential other emerging technologies. Further research directions include long-term studies on ERA-guided pregnancies exploring cases recurrent failure unexplained infertility. Overall, represents significant advancement medicine, offering personalized approach can significantly improve success transfers.

Language: Английский

Citations

1