Association between urinary volatile organic compound metabolites and sarcopenia in the US general population: a cross-sectional NHANES study from 2011 to 2018 DOI Creative Commons
Wei Tang,

Tuotuo Chen,

Zixuan Luo

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 28, 2025

Volatile organic compound (VOC) is a prevalent form of pollutant that has been linked to various human ailments, yet their connection sarcopenia remains uncertain. This study seeks examine the potential association between exposure mixtures metabolites volatile compounds (mVOCs) and sarcopenia, while also investigating mediating effects oxidative stress inflammation. Data from 2011-2018 National Health Nutrition Examination Survey (NHANES) were utilized for analysis relationship mVOCs through logistic regression. The least absolute shrinkage selection operator (LASSO) regression model was employed identify key mVOCs, quantile-g computation (qgcomp) bayesian kernel machine (BKMR) models mVOC sarcopenia. Potential factors explored analysis. Of 2908 participants included in study, 246 individuals (8.5%) found have Logistic revealed five urinary VOC positively correlated with an increased risk identified LASSO method further analyzed using qgcomp, which showed 47% average increase when exposed mixture (OR = 1.47, 95% CI 1.14-1.91). Four components (DHBMA, 3HPMA, ATCA 3,4MHA) largest weight. BKMR results confirm this joint association. Furthermore, Mediation inflammation mediate In conclusion, our provides evidence suggesting heightened potentially serving as mediators relationship. It recommended additional cohort studies be conducted validate these findings.

Language: Английский

Identifying Semaphorin 3C as a Biomarker for Sarcopenia and Coronary Artery Disease Via Bioinformatics and Machine Learning DOI
Ran Shu, Zhuoqi Li,

Xitong Lin

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 131, P. 105762 - 105762

Published: Jan. 15, 2025

Language: Английский

Citations

0
Associations Between Adherence to the Mediterranean Diet and Incident Sarcopenia in Prospective Cohort Studies DOI Open Access
Ligia J. Domínguez, Nicola Veronese, Lee Smith

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 313 - 313

Published: Jan. 16, 2025

The loss of skeletal muscle mass and strength, known as sarcopenia, is prevalent in older adults linked to an increased risk disability, frailty, early mortality. Muscle health crucial for the functionality independence adults. As aging population continuously grows, finding cost-effective strategies preventing treating sarcopenia important public priority. While nutrition recognized a key factor development its role condition still under investigation. In recent decades, nutritional research has shifted from focus on individual nutrients or healthy foods examining combination dietary patterns, along with their potential synergistic antagonistic effects. A balanced diet regular participation physical activity are essential maintaining musculoskeletal health. One eating patterns greatest evidence multiple benefits Mediterranean diet, which also been positive effects function observational studies. However, there lack intervention This review explores updated longitudinal prospective studies associations between adherence order promote preventive aging.

Language: Английский

Citations

0
Association between urinary volatile organic compound metabolites and sarcopenia in the US general population: a cross-sectional NHANES study from 2011 to 2018 DOI Creative Commons
Wei Tang,

Tuotuo Chen,

Zixuan Luo

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 28, 2025

Volatile organic compound (VOC) is a prevalent form of pollutant that has been linked to various human ailments, yet their connection sarcopenia remains uncertain. This study seeks examine the potential association between exposure mixtures metabolites volatile compounds (mVOCs) and sarcopenia, while also investigating mediating effects oxidative stress inflammation. Data from 2011-2018 National Health Nutrition Examination Survey (NHANES) were utilized for analysis relationship mVOCs through logistic regression. The least absolute shrinkage selection operator (LASSO) regression model was employed identify key mVOCs, quantile-g computation (qgcomp) bayesian kernel machine (BKMR) models mVOC sarcopenia. Potential factors explored analysis. Of 2908 participants included in study, 246 individuals (8.5%) found have Logistic revealed five urinary VOC positively correlated with an increased risk identified LASSO method further analyzed using qgcomp, which showed 47% average increase when exposed mixture (OR = 1.47, 95% CI 1.14-1.91). Four components (DHBMA, 3HPMA, ATCA 3,4MHA) largest weight. BKMR results confirm this joint association. Furthermore, Mediation inflammation mediate In conclusion, our provides evidence suggesting heightened potentially serving as mediators relationship. It recommended additional cohort studies be conducted validate these findings.

Language: Английский

Citations

0