Explainable Artificial Intelligence in Neuroimaging of Alzheimer’s Disease

Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 612 - 612

Published: March 4, 2025

Alzheimer's disease (AD) remains a significant global health challenge, affecting millions worldwide and imposing substantial burdens on healthcare systems. Advances in artificial intelligence (AI), particularly deep learning machine learning, have revolutionized neuroimaging-based AD diagnosis. However, the complexity lack of interpretability these models limit their clinical applicability. Explainable Artificial Intelligence (XAI) addresses this challenge by providing insights into model decision-making, enhancing transparency, fostering trust AI-driven diagnostics. This review explores role XAI neuroimaging, highlighting key techniques such as SHAP, LIME, Grad-CAM, Layer-wise Relevance Propagation (LRP). We examine applications identifying critical biomarkers, tracking progression, distinguishing stages using various imaging modalities, including MRI PET. Additionally, we discuss current challenges, dataset limitations, regulatory concerns, standardization issues, propose future research directions to improve XAI's integration practice. By bridging gap between AI interpretability, holds potential refine diagnostics, personalize treatment strategies, advance research.

Language: Английский

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Exploring the effects of combined nostalgic activities and music therapy on Alzheimer's disease outcomes

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Objective Exploring the effects of combination nostalgic activity-based therapies, including music therapy on cognitive function, negative emotions, and sleep quality in patients with mild to moderate Alzheimer's disease. Methods A total 63 disease who were treated at Sichuan Provincial Psychiatric Center People's Hospital Province from January June 2023 selected as research subjects. They randomly divided into a study group ( n = 31) control 32) using random number table method. The received routine treatment nursing care, while intervention basis group. Mini Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MOCA), Self Rating Anxiety Depression (SAS, SDS), Pittsburgh Sleep Quality Index (PSQI) two groups compared. Results 30 cases each completed study. After 12 weeks intervention, MMSE MOCA scores both increased, was higher than P < 0.05); SAS, SDS PSQI decreased compared those before lower 0.05). Conclusion Nostalgic can improve alleviate

Language: Английский

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“Triazole-linked thiazolidinedione-Benzothiazole hybrids: Design and biological evaluation as AChE inhibitors”

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108295 - 108295

Published: Feb. 21, 2025

Language: Английский

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Oral Health Status and Factors Associated with Oral Health in Patients with Alzheimer’s Disease: A Matched Case-Control Observational Study

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1412 - 1412

Published: Feb. 20, 2025

Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease, ranking as the seventh leading cause of death in both sexes. There increasing awareness role periodontal and severe tooth loss modifiable risk factor for developing AD. The aim present observational study was to assess AD patients with non-affected healthy controls context their dental health outcomes; additionally, potential impact anamnestic factors lifestyle habits on oral outcomes also studied. Methods: A total n = 41 receiving treatment at Department Psychiatry, University Szeged, were compared age- gender-matched from individuals seeking retirement homes (mean age 83.32 ± 7.82 years). Dental status indices assessed according World Health Organization (WHO) criteria. Results: Overall, 51.2%, 68.3%, 87.8% received mood stabilizers, drugs non-cognitive symptoms cognitive symptoms, respectively. Severe observed 43.9% 56.1% controls, no significant differences among regarding studied (p > 0.05 all indicators). had significantly higher plaque (%) (59.06 15.45 vs. 41.35 7.97; p < 0.001), bleeding probing (BOP%) (62.65 12.00 40.12 10.86; pocket depth [PD] (2.63 0.56 2.29 0.13; 0.002) attachment [AL] (2.85 0.79 2.39 0.41; 0.026) values, controls. Smoking (vs. non-smokers; 56.28 12.36 51.40 13.23, 0.038) consumption alcohol non-drinkers; 58.68 9.86 54.78 14.86, 0.040) associated [%], while similar effects shown parameters 0.05). In contrast, coffee intake vitamin supplement use effect or cases). Conclusions: results our underscore substantial needs patients, calling heightened healthcare professionals.

Language: Английский

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Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

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