Melatonin as a treatment for atherosclerosis: focus on programmed cell death, inflammation and oxidative stress DOI Creative Commons

Reza Asemi,

Elham Omidi Najafabadi,

Zahra Gholami Mahmoudian

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 12, 2025

Delaying the development of atherosclerosis (AS) and decreasing cardiac ischemia-reperfusion damage remain serious challenges for medical community. Chronic arterial disease, i.e., AS, is frequently linked to oxidative stress inflammation as significant contributing causes. AS risk factors, such hyperlipidemia, high blood pressure, age, hyperglycemia, smoking, cholesterol, irregular sleep patterns, can exacerbate in carotid artery further shrink its lumen. Finding new approaches that support plaque inhibition or stability an ongoing problem. The last ten years have shown us melatonin (MLT) affects cardiovascular system, although exact mechanisms action are yet unknown. MLT's direct free radical scavenger activity, indirect antioxidant qualities, anti-inflammatory capabilities all contribute atheroprotective effects on several pathogenic signaling pathways. Herein, we examine evidence showing MLT treatment has protective against AS-related diseases. numerous pieces puzzle been epigenetic biogenetic targets prevention therapy atherosclerotic processes identified.

Language: Английский

Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting—A Comprehensive Review of Its Unusual Health Benefits DOI Creative Commons
Lucas Fornari Laurindo,

Otávio Augusto Garcia Simili,

Adriano Cressoni Araújo

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 143 - 143

Published: Jan. 30, 2025

Melatonin is indispensable for the homeostasis of plants and animals. In humans, it can help prevent or be an adjuvant treatment several diseases mainly related to immune system, inflammation, oxidative stress. Moreover, a melatonin-rich diet linked health benefits, such as regulation circadian rhythm, immunological epilepsy control, delaying aging process, diminishing hormones cancer. This review aimed show effects melatonin in beyond its traditional use. The results showed present scavenging free radicals, reducing inflammatory cytokines, modulating system. improve insulin resistance, blood pressure, LDL-c, adipose tissue mass, adhesion molecules, endothelial impairment, plaque formation. These result neuro- cardioprotection, improvement liver diseases, rheumatoid arthritis, dermatitis, COVID-19, polycystic ovaries, sepsis. We conclude that plant benefit patients with many besides sleep problems neurodegeneration. Plant may more cost-effective fewer adverse events than synthetic. However, clinical trials should performed adequate doses, formulation, time.

Language: Английский

Citations

0
Melatonin as a treatment for atherosclerosis: focus on programmed cell death, inflammation and oxidative stress DOI Creative Commons

Reza Asemi,

Elham Omidi Najafabadi,

Zahra Gholami Mahmoudian

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 12, 2025

Delaying the development of atherosclerosis (AS) and decreasing cardiac ischemia-reperfusion damage remain serious challenges for medical community. Chronic arterial disease, i.e., AS, is frequently linked to oxidative stress inflammation as significant contributing causes. AS risk factors, such hyperlipidemia, high blood pressure, age, hyperglycemia, smoking, cholesterol, irregular sleep patterns, can exacerbate in carotid artery further shrink its lumen. Finding new approaches that support plaque inhibition or stability an ongoing problem. The last ten years have shown us melatonin (MLT) affects cardiovascular system, although exact mechanisms action are yet unknown. MLT's direct free radical scavenger activity, indirect antioxidant qualities, anti-inflammatory capabilities all contribute atheroprotective effects on several pathogenic signaling pathways. Herein, we examine evidence showing MLT treatment has protective against AS-related diseases. numerous pieces puzzle been epigenetic biogenetic targets prevention therapy atherosclerotic processes identified.

Language: Английский

Citations

0