Effect of COVID-19 vaccination coverage on transmission and mortality during Omicron dominance DOI Creative Commons
Stephen Chukwuma Ogbodo, Joseph Junior Damba, Omotayo Olaoye

et al.

Academia Medicine, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 24, 2025

Background: During the coronavirus disease 2019 (COVID-19) pandemic, emergence of Omicron SARS-CoV2 variant raised concerns about reduction in vaccine effectiveness due to its higher transmissibility. Thus, using ecologic data, we assessed population-level impact COVID-19 vaccination coverage on transmission and mortality, during period dominance globally. Subject methods: We used a longitudinal dataset 110 countries over 16 months (January 2022 April 2023). Applying random-effects regression models, effect monthly full rates newly confirmed cases deaths, adjusting for country characteristics. obtained data from open-access databases, including World Health Organization (WHO) Dashboard Oxford Government Response Tracker. Results: On average, each 1% point increase was associated with 1.4% (95% confidence interval (CI): 0.1%–2.8%, p = 0.035) rate new 5% CI: 3.6%–6.4%, < 0.001) deaths. This protective graded across levels coverage: compared <50% coverage, those coverages 50%–59%, 60%–69%, 70%–79%, ≥80% had 20.5% –16.4%–45.7%), 53.8% (22.6%–72.5%), 54.3% (15.5%–75.3%), 69.6% (38.7%–84.9%) lower cases, respectively, average. Conclusions: Our findings suggest an important role mitigating pandemics, particularly despite highly transmissible variants like Omicron.

Language: Английский

Effect of COVID-19 vaccination coverage on transmission and mortality during Omicron dominance DOI Creative Commons
Stephen Chukwuma Ogbodo, Joseph Junior Damba, Omotayo Olaoye

et al.

Academia Medicine, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 24, 2025

Background: During the coronavirus disease 2019 (COVID-19) pandemic, emergence of Omicron SARS-CoV2 variant raised concerns about reduction in vaccine effectiveness due to its higher transmissibility. Thus, using ecologic data, we assessed population-level impact COVID-19 vaccination coverage on transmission and mortality, during period dominance globally. Subject methods: We used a longitudinal dataset 110 countries over 16 months (January 2022 April 2023). Applying random-effects regression models, effect monthly full rates newly confirmed cases deaths, adjusting for country characteristics. obtained data from open-access databases, including World Health Organization (WHO) Dashboard Oxford Government Response Tracker. Results: On average, each 1% point increase was associated with 1.4% (95% confidence interval (CI): 0.1%–2.8%, p = 0.035) rate new 5% CI: 3.6%–6.4%, < 0.001) deaths. This protective graded across levels coverage: compared <50% coverage, those coverages 50%–59%, 60%–69%, 70%–79%, ≥80% had 20.5% –16.4%–45.7%), 53.8% (22.6%–72.5%), 54.3% (15.5%–75.3%), 69.6% (38.7%–84.9%) lower cases, respectively, average. Conclusions: Our findings suggest an important role mitigating pandemics, particularly despite highly transmissible variants like Omicron.

Language: Английский

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