Novel Gels for Post-Piercing Care: Evaluating the Efficacy of Pranoprofen Formulations in Reducing Inflammation DOI Creative Commons

Negar Ahmadi,

María Rincón, Mireia Mallandrich

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 334 - 334

Published: April 30, 2025

Mild to moderate pain for a few hours several days post-piercing is normal, and the usually accompanied by swelling, redness, warmth due inflammatory response. Cool compresses over-the-counter analgesics (e.g., NSAIDs) can ease mild discomfort. However, oral NSAIDs may have systemic side effects; this reason, we propose topical anti-inflammatory approach. Four pranoprofen-loaded gels were created using different gelling agents: Sepigel® 305 (PF-Gel-Sep), Carbopol® 940 (PF-Gel-Car), Pluronic® F-68 (PF-Gel-Plu), Lutrol® F-127 (PF-Gel-Lut). The assessed pH, morphology, FT-IR spectroscopy, rheological properties, spreadability, swelling degradation, drug release kinetics, skin permeation (cow human skin), irritation potential (HET-CAM assay), impact on barrier function (TEWL SCH). exhibited varied properties with PF-Gel-Car showing high viscosity PF-Gel-Plu very low viscosity. All had similar spreadability PF-Gel-Lut highest. showed highest amounts of PF released, whereas led amount pranoprofen retained in bovine skin. HET-CAM assay indicated that none PF-Gels irritating. Additionally, no cytotoxic effects HaCaT cells. In vivo testing mice prevented inflammation, while rest able revert it 25 min. Skin tolerance tests revealed did not affect TEWL, some improved SCH. study successfully formulated characterized four PF-loaded be used as an alternative treating inflammation from piercings ear tags.

Language: Английский

Novel Gels for Post-Piercing Care: Evaluating the Efficacy of Pranoprofen Formulations in Reducing Inflammation DOI Creative Commons

Negar Ahmadi,

María Rincón, Mireia Mallandrich

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 334 - 334

Published: April 30, 2025

Mild to moderate pain for a few hours several days post-piercing is normal, and the usually accompanied by swelling, redness, warmth due inflammatory response. Cool compresses over-the-counter analgesics (e.g., NSAIDs) can ease mild discomfort. However, oral NSAIDs may have systemic side effects; this reason, we propose topical anti-inflammatory approach. Four pranoprofen-loaded gels were created using different gelling agents: Sepigel® 305 (PF-Gel-Sep), Carbopol® 940 (PF-Gel-Car), Pluronic® F-68 (PF-Gel-Plu), Lutrol® F-127 (PF-Gel-Lut). The assessed pH, morphology, FT-IR spectroscopy, rheological properties, spreadability, swelling degradation, drug release kinetics, skin permeation (cow human skin), irritation potential (HET-CAM assay), impact on barrier function (TEWL SCH). exhibited varied properties with PF-Gel-Car showing high viscosity PF-Gel-Plu very low viscosity. All had similar spreadability PF-Gel-Lut highest. showed highest amounts of PF released, whereas led amount pranoprofen retained in bovine skin. HET-CAM assay indicated that none PF-Gels irritating. Additionally, no cytotoxic effects HaCaT cells. In vivo testing mice prevented inflammation, while rest able revert it 25 min. Skin tolerance tests revealed did not affect TEWL, some improved SCH. study successfully formulated characterized four PF-loaded be used as an alternative treating inflammation from piercings ear tags.

Language: Английский

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