Associations Between Behavioral Addictions and Mental Health Concerns During the COVID-19 Pandemic: A Systematic Review and Meta-analysis

Current Addiction Reports, Journal Year: 2024, Volume and Issue: 11(3), P. 565 - 587

Published: March 14, 2024

Abstract Purpose of Review The COVID-19 pandemic has promoted behavioral changes and elevated mental distress. Addictive behaviors often increased, generating health problems. present study’s primary aim was to investigate associations between different types addictions (including addictions, related conditions, phenomena) secondary aims were: (i) identify possible sources heterogeneity (ii) explore potential moderators in Recent Findings Using Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA), studies from the period December 2019 May 2023 were sought PubMed , Scopus ISI Web Knowledge Google Scholar its first ten pages. articles’ relevance screened evaluated. included papers’ quality assessed according Newcastle Ottawa Scale. Fisher’s Z scores computed magnitudes I 2 indices used estimate levels meta-analysis. Among 85 (N = 104,425 23 countries; mean age 24.22 years; 60.77% female), most internet-related phenomena (28 on social media, 25 internet, smartphone, 12 gaming). pooled estimation showed that higher internet use (regardless type) associated with more problems which type). Moderator analyses almost no variables affected founded associations. Summary Most focused behaviors, suggesting relationships specific during pandemic. Moreover, found systematic review meta-analysis comparable identified conducted before How help people reduce address concerns are important topics healthcare providers.

Language: Английский

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Opportunities and challenges of RiPP-based therapeutics

Natural Product Reports, Journal Year: 2024, Volume and Issue: 41(7), P. 990 - 1019

Published: Jan. 1, 2024

Covering: up to 2024Ribosomally synthesised and post-translationally modified peptides (RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy bioactivities ranging from antiinfective anticancer analgesic effects. Furthermore, RiPP biosynthetic pathways represent promising production routes for complex drugs, the technology is well-suited engineering produce derivatives with specific functions. Thus, possess features that render them potentially ideal candidates drug discovery development. Nonetheless, only small number RiPP-derived compounds have successfully reached market thus far. This review initially outlines therapeutic opportunities RiPP-based can offer, whilst subsequently discussing limitations require resolution in order fully exploit potential RiPPs towards development innovative drugs.

Language: Английский

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COVID-19 Pandemic and Vaccines Update on Challenges and Resolutions

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Sept. 10, 2021

The coronavirus disease (COVID-19) is caused by a positive-stranded RNA virus called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), belonging to the Coronaviridae family. This originated in Wuhan City, China, and became cause of multiwave pandemic that has killed 3.46 million people worldwide as May 22, 2021. havoc intensified with emergence SARS-CoV-2 variants (B.1.1.7; Alpha, B.1.351; Beta, P.1; Gamma, B.1.617; Delta, B.1.617.2; Delta-plus, B.1.525; Eta, B.1.429; Epsilon etc.) due mutations generated during replication. More may emerge additional waves. most promising approach for combating viruses their emerging lies prophylactic vaccines. Several vaccine candidates are being developed using various platforms, including nucleic acids, live attenuated virus, inactivated viral vectors, protein-based subunit In this unprecedented time, 12 vaccines against have been phased following WHO approval, 184 preclinical stage, 100 clinical development process. Many them directed elicit neutralizing antibodies spike protein (S) inhibit entry through ACE-2 receptor host cells. Inactivated vaccines, contrary, provide wide range antigens immune activation. Being an intracellular pathogen, cytotoxic CD8+ T Cell (CTL) response remains crucial all viruses, SARS-CoV-2, needs be explored detail. review, we try describe compare approved currently distributed either after phase III trials or emergency use. We discuss responses induced candidate formulations; benefits, potential limitations, effectiveness variants; future challenges, such antibody-dependent enhancement (ADE); safety issues possible resolutions. Most current showing compromised efficacy new variants. Multiple antigen-based (multivariant vaccines) should on different platforms tackle Alternatively, recombinant BCG, containing multiple antigens, long-term protection. Irrespective efficacy, efficient providing protection from severity. must insist compliance age groups work hesitancy globally achieve herd immunity and, eventually, curb pandemic.

Language: Английский

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Changes of Exercise, Screen Time, Fast Food Consumption, Alcohol, and Cigarette Smoking during the COVID-19 Pandemic among Adults in the United States

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3359 - 3359

Published: Sept. 25, 2021

Objective: To investigate the impact of COVID-19 pandemic on multiple lifestyle changes among adults in United States (USA). Methods: We conducted a survey, Health, Ethnicity, and Pandemic (HEAP) Study, October 2020 USA adults. Participants were selected from using 48 sampling strata, including age, race, ethnicity, education, gender, asked to report five behaviors (i.e., exercise time, screen fast-food meal consumption, alcohol drinking, cigarette smoking) before during pandemic. The associations sociodemographic factors with each change estimated weighted multivariable logistic regression models. Results: All 2709 HEAP participants included this study. Compared pre-pandemic, time spent decreased (32.06 vs. 38.65 min/day; p < 0.001) increased (6.79 5.06 h/day; percentage individuals who reported consuming meals ≥3 times/week 37.7% 33.3% heavy drinkers (≥5 times/week) 20.9% 25.7% Among smokers, smoking (≥11 cigarettes/day) 5.8% 7.9% also identified subgroups more vulnerable adverse influences pandemic, racial/ethnic minority groups young Conclusions: had negative impacts Americans. Mitigating such requires effective interventions, particularly for some subgroups.

Language: Английский

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Comparison of Nurse Burnout, Before and During the COVID-19 Pandemic

Nursing Clinics of North America, Journal Year: 2021, Volume and Issue: 57(1), P. 79 - 99

Published: Nov. 9, 2021

Language: Английский

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Recently spreading human monkeypox virus infection and its transmission during COVID-19 pandemic period: A travelers' prospective

Travel Medicine and Infectious Disease, Journal Year: 2022, Volume and Issue: 49, P. 102398 - 102398

Published: June 29, 2022

Language: Английский

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Microplastics in the Ecosystem: An Overview on Detection, Removal, Toxicity Assessment, and Control Release

Water, Journal Year: 2022, Volume and Issue: 15(1), P. 51 - 51

Published: Dec. 23, 2022

In recent decades, the accumulation and fragmentation of plastics on surface planet have caused several long-term climatic health risks. Plastic materials, specifically microplastics (MPs; sizes < 5 mm), gained significant interest in global scientific fraternity due to their bioaccumulation, non-biodegradability, ecotoxicological effects living organisms. This study explains how are generated, transported, disposed environment based sources physicochemical properties. Additionally, also examines impact COVID-19 plastic waste production. The physical chemical techniques such as SEM-EDX, PLM, FTIR, Raman, TG-DSC, GC-MS that employed for quantification identification MPs discussed. paper provides insight into conventional advanced methods applied microplastic removal from aquatic systems. finding this review helps gain a deeper understanding research toxicity humans, organisms, soil ecosystems. Further, efforts measures been enforced globally combat MP highlighted need be explored reduce its potential risk future.

Language: Английский

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Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CLpro: Inhibition potentials, covalent binding sites and inhibitory mechanisms

International Journal of Biological Macromolecules, Journal Year: 2021, Volume and Issue: 187, P. 976 - 987

Published: July 30, 2021

Language: Английский

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Current view on novel vaccine technologies to combat human infectious diseases

Applied Microbiology and Biotechnology, Journal Year: 2021, Volume and Issue: 106(1), P. 25 - 56

Published: Dec. 10, 2021

Language: Английский

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Clinical development and approval of COVID-19 vaccines

Expert Review of Vaccines, Journal Year: 2022, Volume and Issue: 21(5), P. 609 - 619

Published: Feb. 14, 2022

The coronavirus 19 (COVID-19) pandemic triggered a simultaneous global demand for preventative vaccines, which quickly became high priority among governments as well academia and the pharmaceutical industry. Within less than year after COVID-19 was declared pandemic, vaccines had received emergency approvals vaccination campaigns were initiated.We discuss several factors that led to unprecedented, accelerated development approval of includes optimization processes by regulatory authorities, redesign sequential processes, learnings from previous pandemics, prior novel vaccine platforms.Despite unanticipated complex challenges presented real-time in context evolving subsequent ever-changing landscape public health measures recommendations, important milestones reached within extraordinarily short periods and, following roll-out billions worldwide, approved have proven be tolerated effective. Whilst this is an exceptional feat example what can achieved with collaboration innovation, there are lessons still learned, including need further harmonization between modes react pandemic's ever-evolving challenges, ensuring equitable access low-income countries.

Language: Английский

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