Tapping the biosynthetic potential of marine Bacillus licheniformis LHG166, a prolific sulphated exopolysaccharide producer: structural insights, bio-prospecting its antioxidant, antifungal, antibacterial and anti-biofilm potency as a novel anti-infective lead DOI Creative Commons
Nada K. Alharbi, Zahraa Falah Azeez, Haitham Alhussain

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

The escalating global threat of antimicrobial resistance necessitates prospecting uncharted microbial biodiversity for novel therapeutic leads. This study mines the promising chemical richness Bacillus licheniformis LHG166, a prolific exopolysaccharide (EPSR2-7.22 g/L). It comprised 5 different monosaccharides with 48.11% uronic acid, 17.40% sulfate groups, and 6.09% N-acetyl glucosamine residues. EPSR2 displayed potent antioxidant activity in DPPH ABTS + , TAC FRAP assays. Of all fungi tested, yeast Candida albicans highest susceptibility antibiofilm inhibition. Aspergillus niger Penicillium glabrum showed moderate susceptibility. In contrast, Mucor circinelloides Trichoderma harzianum were resistant. Among G+ve tested bacteria, Enterococcus faecalis was most susceptible, while Salmonella typhi sensitive to G−ve pathogens. Encouragingly, predominantly demonstrated bactericidal effects against both bacterial classes based on MBC/MIC either 1 or 2 superior Gentamicin. At 75% MBC, anti-biofilm 88.30% B. subtilis inhibition, 96.63% Escherichia coli Even at lowest dose 25% reduced biofilm formation by 84.13% E. 61.46% . metabolite from LHG166 shows promise as an eco-friendly natural antibiotic alternative treating infections oxidative stress.

Language: Английский

The Many Faces of Enterococcus spp.—Commensal, Probiotic and Opportunistic Pathogen DOI Creative Commons
Beata Krawczyk, Paweł Wityk, Mirosława Gałęcka

et al.

Microorganisms, Journal Year: 2021, Volume and Issue: 9(9), P. 1900 - 1900

Published: Sept. 7, 2021

Enterococcus spp. are Gram-positive, facultative, anaerobic cocci, which found in the intestinal flora and, less frequently, vagina or mouth. faecalis and faecium most common species humans. As commensals, enterococci colonize digestive system participate modulation of immune humans animals. For many years reference enterococcal strains have been used as probiotic food additives recommended supplements for treatment dysbiosis other conditions. The use probiotics has recently become controversial due to ease acquiring different virulence factors resistance various classes antibiotics. Enterococci also seen opportunistic pathogens. This problem is especially relevant hospital environments, where outbreaks often occur. Their ability translocate from gastro-intestinal tract tissues organs well their antibiotic risk that hinder eradication. Due numerous reports on plasticity genome acquisition pathogenic microbial features, we ask ourselves, how far this commensal genus pathogenicity? paper discusses both beneficial properties these microorganisms related evolution towards pathogenicity.

Language: Английский

Citations

244
How plants recruit their microbiome? New insights into beneficial interactions DOI Creative Commons
Gustavo Santoyo

Journal of Advanced Research, Journal Year: 2021, Volume and Issue: 40, P. 45 - 58

Published: Dec. 4, 2021

Research on beneficial mechanisms by plant-associated microbiomes, such as plant growth stimulation and protection from pathogens, has gained considerable attention over the past decades; however, used plants to recruit their microbiome is largely unknown.Here, we review latest studies that have begun reveal strategies in selectively recruiting how they manage exclude potential pathogens. Key Scientific concepts of Review: We examine attract microbiota main areas interaction, rhizosphere, endosphere, phyllosphere, demonstrate process occurs producing root exudates, recognizing molecules produced or distinguishing pathogens using specific receptors, triggering signals support plant-microbiome homeostasis. Second, analyzed environmental biotic factors modulate structure successional dynamics microbial communities. Finally, associated capable engaging with other synergistic microbes, hence providing an additional element selection. Collectively, this study reveals importance understanding complex network interactions, which will improve bioinoculant application agriculture, based a interacts efficiently organs under different conditions.

Language: Английский

Citations

199
Exopolysaccharides Produced by Lactic Acid Bacteria: From Biosynthesis to Health-Promoting Properties DOI Creative Commons
Dominika Jurášková, Susana C. Ribeiro, C.C.G. Silva

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(2), P. 156 - 156

Published: Jan. 8, 2022

The production of exopolysaccharides (EPS) by lactic acid bacteria (LAB) has attracted particular interest in the food industry. EPS can be considered as natural biothickeners they are produced situ LAB and improve rheological properties fermented foods. Moreover, much research been conducted on beneficial effects modulating gut microbiome promoting health. EPS, which varies widely composition structure, may have diverse health effects, such glycemic control, calcium magnesium absorption, cholesterol-lowering, anticarcinogenic, immunomodulatory, antioxidant effects. In this article, latest advances biosynthesis, physicochemical LAB-derived described detail. This is followed a summary up-to-date methods used to detect, characterize elucidate structure LAB. addition, current strategies use LAB-produced products discussed, focusing applications dairy products, gluten-free bakery low-fat meat positively influence consistency, stability, quality final product. Highlighting also placed reports health-promoting with emphasis prebiotic, antioxidant, anti-biofilm, antimicrobial, anticancer, drug-delivery activities.

Language: Английский

Citations

187
Fermented foods: An update on evidence-based health benefits and future perspectives DOI
Iñaki Diez‐Ozaeta,

Oihana Juaristi Astiazaran

Food Research International, Journal Year: 2022, Volume and Issue: 156, P. 111133 - 111133

Published: March 15, 2022

Language: Английский

Citations

93
Rhizobiome engineering: Unveiling complex rhizosphere interactions to enhance plant growth and health DOI Creative Commons
Ma. del Carmen Orozco-Mosqueda, Ayomide Emmanuel Fadiji, Olubukola Oluranti Babalola

et al.

Microbiological Research, Journal Year: 2022, Volume and Issue: 263, P. 127137 - 127137

Published: July 16, 2022

Language: Английский

Citations

90
Bacterial exopolysaccharides as emerging bioactive macromolecules: from fundamentals to applications DOI Creative Commons
Navneet Kaur, Priyankar Dey

Research in Microbiology, Journal Year: 2022, Volume and Issue: 174(4), P. 104024 - 104024

Published: Dec. 30, 2022

Language: Английский

Citations

89
Decrypting the multi-functional biological activators and inducers of defense responses against biotic stresses in plants DOI Creative Commons
Bahman Khoshru, Debasis Mitra, Kuldeep Joshi

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(3), P. e13825 - e13825

Published: Feb. 18, 2023

Plant diseases are still the main problem for reduction in crop yield and a threat to global food security. Additionally, excessive usage of chemical inputs such as pesticides fungicides control plant have created another serious human environmental health. In view this, application growth-promoting rhizobacteria (PGPR) controlling disease incidences has been identified an eco-friendly approach coping with security issue. this review, we different ways by which PGPRs capable reducing phytopathogenic infestations enhancing yield. PGPR suppresses diseases, both directly indirectly, mediated microbial metabolites signaling components. Microbial synthesized anti-pathogenic siderophores, antibiotics, lytic enzymes, hydrogen cyanide, several others act on phytopathogens. The indirect mechanisms infestation caused stimulation immune responses known initiation systemic resistance (ISR) is triggering elicited through pathogen-associated molecular patterns (PAMPs). ISR triggered infected region leads development acquired (SAR) throughout making resistant wide range pathogens. A number including Pseudomonas Bacillus genera proven their ability stimulate ISR. However, there some challenges large-scale acceptance pest management. Further, discuss newly formulated inoculants possessing activities suppression holistic sustaining health productivity.

Language: Английский

Citations

52
Recent advances in the biological activities of microbial exopolysaccharides DOI Open Access
Fatemeh Salimi, Parisa Farrokh

World Journal of Microbiology and Biotechnology, Journal Year: 2023, Volume and Issue: 39(8)

Published: May 31, 2023

Language: Английский

Citations

46
Quorum Sensing of Bifidobacteria: Research and Progress DOI
Huahui Li, Bin He,

Ning Ma

et al.

Microbiological Research, Journal Year: 2025, Volume and Issue: 294, P. 128102 - 128102

Published: Feb. 13, 2025

Language: Английский

Citations

2
Biological Functions of Exopolysaccharides from Lactic Acid Bacteria and Their Potential Benefits for Humans and Farmed Animals DOI Creative Commons

María Laura Werning,

Annel M. Hernández-Alcántara, María Julia Ruiz

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(9), P. 1284 - 1284

Published: April 28, 2022

Lactic acid bacteria (LAB) synthesize exopolysaccharides (EPS), which are structurally diverse biopolymers with a broad range of technological properties and bioactivities. There is scientific evidence that these polymers have health-promoting properties. Most commercialized probiotic microorganisms for consumption by humans farmed animals LAB some them EPS-producers indicating their beneficial could be due to polymers. Probiotic currently used improve human health the prevention treatment specific pathologic conditions. They also in food-producing animal husbandry, mainly abilities promote growth inhibit pathogens via different mechanisms, among production EPS involved. Thus, aim this review discuss current knowledge characteristics, usage biological role from LAB, as well postbiotic action animals, predict future contribution they on diet food productivity, status impact public health.

Language: Английский

Citations

69