Revelation of inherent trends in Mucormycosis resurgence in India: A comparative analysis of past prevalence (pre-Covid-19) and current outbreaks DOI Creative Commons

Pratibha Pant,

Prashant Pant,

Vijay Rani Rajpal

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 9, 2023

Abstract Mucormycosis (MM), commonly referred to as ‘Black Fungus’ was a relatively lesser-known fungal infection until the onset of Covid-19 pandemic. However, amidst global outbreak, it emerged widespread causing significant morbidity and mortality. In India, recorded incidence MM approximately 80% higher than in rest world due prevalence specific pre-disposing factors, causal organisms, clinical manifestations, intriguing epidemiological trends. This study compared case-control studies conducted India before pandemic during current comprehend impact on surge cases. Our findings demonstrate that is distinct condition which not solely dependent Covid-19. Interestingly, trends association with comorbidities like diabetes its greater male gender remains consistent both periods. The increased occurrence appears be more intricately linked challenges management treatment Covid-19, leading emergence novel predisposing factors. indiscriminate use steroids, immunosuppressants, resultant hyperglycemic condition, especially population already burdened comorbidity contributed significantly havoc. suggests raising general awareness about preventive measures, regulation steroid drug misuse can play crucial role curtailing development spread deadly infections future.

Language: Английский

In Silico Evaluation of Antifungal Compounds from Marine Sponges against COVID-19-Associated Mucormycosis DOI Creative Commons
Omkar Pokharkar,

Hariharan Lakshmanan,

Grigory V. Zyryanov

et al.

Marine Drugs, Journal Year: 2022, Volume and Issue: 20(3), P. 215 - 215

Published: March 20, 2022

The world is already facing the devastating effects of SARS-CoV-2 pandemic. A disseminated mucormycosis epidemic emerged to worsen this situation, causing havoc, especially in India. This research aimed perform a multitargeted docking study marine-sponge-origin bioactive compounds against mucormycosis. Information on proven drug targets and marine sponge was obtained via literature search. total seven different were selected. Thirty-five chosen using PASS online program. For homology modeling molecular docking, FASTA sequences 3D structures for protein retrieved from NCBI PDB databases. Autodock Vina PyRx 0.8 used studies. Further, dynamics simulations performed IMODS server top-ranked docked complexes. Moreover, drug-like properties toxicity analyses Lipinski parameters Swiss-ADME, OSIRIS, ProTox-II, pkCSM, StopTox servers. results indicated that naamine D, latrunculin S, (+)-curcudiol, (+)-curcuphenol, aurantoside I, hyrtimomine had highest binding affinity values -8.8, -8.6, -9.8, -11.4, -8.0, -9.0 kcal/mol, respectively. In sum, all MNPs included are good candidates (+)-curcudiol (+)-curcuphenol promising due their broad-spectrum target inhibition potential.

Language: Английский

Citations

29
Epidemiology, Modern Diagnostics, and the Management of Mucorales Infections DOI Creative Commons
David Pham, Annaleise R. Howard‐Jones,

Rebecca Sparks

et al.

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(6), P. 659 - 659

Published: June 12, 2023

Mucormycosis is an uncommon, yet deadly invasive fungal infection caused by the Mucorales moulds. These pathogens are a WHO-assigned high-priority pathogen group, as mucormycosis incidence increasing, and there unacceptably high mortality with current antifungal therapies. Current diagnostic methods have inadequate sensitivity specificity may issues accessibility or turnaround time. Patients diabetes mellitus immune compromise predisposed to these environmental fungi, but COVID-19 has established itself new risk factor. also cause healthcare-associated outbreaks, clusters associated natural disasters been identified. Robust epidemiological surveillance into burden of disease, at-risk populations, emerging required. Emerging serological molecular techniques offer faster route diagnosis, while newly developed agents show promise in preliminary studies. Equitable access therapies will be key identifying treating mucormycosis, delayed initiation therapy higher mortality.

Language: Английский

Citations

15
Post-COVID-19-Associated Mucormycosis: An Observational Study with Clinical and Radiographical Presentation DOI Creative Commons
Shahana Parveen, Ruchi Agrawal, Minal M Kshirsagar

et al.

Advances in Human Biology, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Abstract Introduction: Mucormycosis is an emerging fungal infection increasingly affecting COVID-19 patients, especially those with diabetes. Rhizopus oryzae thrives in high-iron conditions, causing angioinvasion and tissue necrosis. As reported 31%–50% of cases during COVID-19’s second wave, early diagnosis management are crucial to prevent severe complications fatalities. Materials Methods: We conducted a multicentre retrospective study analyse the clinicoepidemiological profile mucormycosis non-COVID-19 patients. Amongst 492 screened cases, 47 confirmed patients were included. Data collection focused on demographics, clinical features, comorbidities, risk factors, treatments diagnostic findings. Results: COVID-19-associated (CAM) them, 25 had history symptoms, while 15 showed no significant history. The aimed provide data CAM acute recent cases. Conclusion: rapidly spreading disease prolonged corticosteroids or This highlights radiographic emphasising diagnosis. A larger recommended.

Language: Английский

Citations

0
Mucormycosis an added burden to Covid-19 Patients: An in-depth systematic review DOI Creative Commons
Naveed Nazir Shah,

Zaid Khan,

Hashim Ahad

et al.

Journal of Infection and Public Health, Journal Year: 2022, Volume and Issue: 15(11), P. 1299 - 1314

Published: Oct. 14, 2022

As of 25th July, 2022, global Disease burden 575,430,244 confirmed cases and over 6,403,511 deaths have been attributed to coronavirus disease 2019 (COVID-19). Co-infections/secondary infections continue plague patients around the world as result co-morbidities like diabetes mellitus, biochemical changes caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) especially significant elevation in free iron levels, immune suppression SARS-CoV-2, indiscriminate use systemic corticosteroids for treatment severe COVID-19 disease. In such circumstances, opportunistic fungal pose challenge therapy with other co-morbidities. Although COVID-19-associated Mucormycosis (CAM) has widely recognized, currently extensive research is being conducted on mucormycosis. It agreed that undergoing corticosteroid are highly susceptible CAM, henceforth high index screening intensive care management need an hour order favorable outcomes these patients. Diagnosis often delayed eventually progresses quickly which poses added clinician increases patient load critical units hospitals. A vast perusal literature indicated mellitus those might be vulnerable develop present work, case series three presented at Chest Hospital Srinagar, Jammu Kashmir infected CAM described their epidemiological data supplementary section. All were found affected co-morbidity Diabetes Mellitus (DM) under therapy. Furthermore, given death rate linked mucormycosis growing understanding diseases significance, systematic review discussed we attempted discuss emerging related aspects

Language: Английский

Citations

16
Nanotechnology-based fungal detection and treatment: current status and future perspective DOI
Vinay Chaudhari,

Vaishnavi Vairagade,

Ami Thakkar

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(1), P. 77 - 97

Published: Aug. 19, 2023

Language: Английский

Citations

7
Hematological Indices in COVID-19 Patients with Rhinosinusitis Mucormycosis. DOI

Seyedeh Sabereh Mojtahedi,

Hossein Zarrinfar, Mehdi Bakhshaee

et al.

PubMed, Journal Year: 2024, Volume and Issue: 36(2), P. 399 - 405

Published: March 1, 2024

Rhinosinusitis mucormycosis (RM) is an invasive opportunistic fungal infection, especially among COVID-19 patients. The current study aimed to assess the peripheral blood hematological disorders of patients-associated RM.

Language: Английский

Citations

2
Updates in Mucormycosis DOI
Mary M. Czech, Jennifer Cuéllar-Rodríguez

Infectious Disease Clinics of North America, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

2
Ruthenium nanoparticles encrusted with nitrogen & sulphur magnetic quantum dots as an efficient electrochemical sensor for simultaneous determination of itraconazole and terbinafine; a dual regimen for black fungus: Magnetic solid phase micro-extraction for urine and plasma analysis DOI
Marwa F. B. Ali, Marwa R. El‐Zahry

Microchemical Journal, Journal Year: 2023, Volume and Issue: 197, P. 109763 - 109763

Published: Dec. 7, 2023

Language: Английский

Citations

5
Clinical Phenotypes of COVID-19 Associated Mucormycosis (CAM): A Comprehensive Review DOI Creative Commons
Maria Panagiota Almyroudi, Karolina Akinosoglou, Jordi Rello

et al.

Diagnostics, Journal Year: 2022, Volume and Issue: 12(12), P. 3092 - 3092

Published: Dec. 8, 2022

A mucormycosis surge was reported during the COVID-19 pandemic in India. literature search until 14 July 2022, with aim of updating COVID-19-associated (CAM), identified 663 studies and 88 met inclusion criteria (8727 patients). India 8388 patients, Egypt 208 Europe 40. Rhino-orbito-cerebral (ROCM) among 8082 (98.3%) followed by 98 (1.2%) pulmonary. In India, 82.6% patients had diabetes mellitus, 82% receiving corticosteroids. Europe, 75% presented pulmonary CAM, 32.5% 40% were immunocompromised. CAM at a median 17.4 days (IQR 7.5 days) post diagnosis, PCR performed five studies. Rhino-orbital invasion is clinically obvious, while cerebral involvement presents cavernous sinus thrombosis, meningitis cerebrovascular disease. Symptoms usually overlap severe pneumonia. High-dose liposomal Amphotericin B (and early surgical debridement ROCM) are mainstay therapy. The mortality rate estimated to be 21.4% 31.9%), increased presence (80% 50%) or (50% 63.9%). summary, different clinical phenotypes need distinguished, influenced geographical presentation. Opportunities exist for diagnosis therapy optimization, based on earlier high-dose antifungal therapy, source control, strict glycemic control restriction steroids oxygen requirements.

Language: Английский

Citations

9
Detecting and characterizing new endofungal bacteria in new hosts: Pandoraea sputorum and Mycetohabitans endofungorum in Rhizopus arrhizus DOI Creative Commons
Xiaoling Liu, Heng Zhao, Yixin Wang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 29, 2024

The fungus Rhizopus arrhizus (= R. oryzae ) is commonly saprotrophic, exhibiting a nature of decomposing organic matter. Additionally, it serves as crucial starter in food fermentation and can act pathogen causing mucormycosis humans animals. In this study, two distinct endofungal bacteria (EFBs), associated with individual strains , were identified using live/dead staining, fluorescence situ hybridization, transmission electron microscopy, 16S rDNA sequencing. roles these elucidated through antibiotic treatment, pure cultivation, comparative genomics. bacterial endosymbionts, Pandoraea sputorum EFB03792 Mycetohabitans endofungorum EFB03829, purified from the host fungal XY03792 XY03829, respectively. Notably, study marks first report an EFB genus. Compared to its free-living counterparts, P. exhibited 28 specific virulence factor-related genes, six CE10 family 74 genes type III secretion system (T3SS), emphasizing pivotal role invasion colonization. Furthermore, introduces new for M. contributing sporulation. Despite visibly reduced genome, EFB03829 displayed substantial number T3SS mobile elements, significant gene rearrangement. While EFBs have been previously their toxin-producing potential has not explored until study. discovery highlights toxin production within laying groundwork identifying suitable processes.

Language: Английский

Citations

1