Cited by Effects of Different Carbohydrate Content Diet on Gut Microbiota and Aortic Calcification in Diabetic Mice

Systematic Review of the Effectiveness of Common Probiotic Strains: Streptococcus faecalis, Clostridium butyricum, Bacillus mesentericus, and Lactobacillus sporogenes in the Management of Diabetes DOI

Basavaraj G. Sooragonda,

Preyander Thakur,

Rajesh Moganti

et al.

Journal of Diabetology, Journal Year: 2025, Volume and Issue: 16(1), P. 29 - 36

Published: Jan. 1, 2025

Abstract Type 2 diabetes mellitus is often linked to changes in gut microbiota, and probiotics may play a significant role the management. Four common probiotic strains: Streptococcus faecalis (Enterococcus faecalis) , Clostridium butyricum Bacillus mesentericus Lactobacillus sporogenes are commonly used treating disorders. The current systematic review evaluates efficacy of these strains management diabetes. C. produces butyrate, which has been shown regulate blood sugar levels, restore intestinal health, mitigate inflammation. S. Faecalis effectiveness lowering postprandial glucose peaks, especially research conducted on silkworm models cell cultures. However, further studies necessary determine long-term humans. shows evidence emphasizes necessity for investigation identify describe active constituents, comprehend processes by they operate, investigate potential synergistic effects combining various achieve improved therapeutic results. Incorporating into enhance metabolic health.

Language: Английский

Citations

Exploring the impact of type 2 diabetes and glucose-lowering drugs on gut microbiome dynamics DOI

Hina Tariq, Niaz Muhammad Khan, Haseeb Manzoor

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 17, 2025

Language: Английский

Citations

Alterations of the gut microbiota in patients with diabetic nephropathy and its association with the renin-angiotensin system DOI

Fatemeh Zali,

Abdorrahim Absalan, Golnaz Bahramali

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 20, 2025

Language: Английский

Citations

Dendrobium officinale leaf phenolic extracts alleviate diabetes mellitus in mice via modulating metabolism and reshaping gut microbiota DOI

Yang Chen, Hailong Yang, Zhexuan Xu

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Abstract BACKGROUND Diabetes mellitus is a chronic metabolic disorder posing significant public health challenge. Dendrobium officinale valuable edible‐medicinal homologous plant. Phenolic extracts from fermented D. leaves (DOLP) demonstrate hypoglycemic effect. However, the effects of DOLP on physiological metabolism and gut microbiota under diabetic conditions remain unknown. RESULTS Untargeted metabolomics analysis revealed that reversed 98 significantly differential metabolites (SDMs) in mice. Indoxyl sulfate palmitoyl sphingomyelin were identified as primary candidate biomarkers associated with KEGG pathway enrichment underscored significance arginine proline metabolism, ascorbate aldarate fatty acid regulatory DOLP. Furthermore, dysbiosis mice, influencing relative abundance genera Intestinimonas , GCA_900066575 Muribaculum Enterorhabdus . These exhibited various correlations SDMs, including l ‐hydroxyarginine, γ‐guanidinobutyrate, ‐threonate, d ‐galactarate, ‐ascorbic acid, palmitic cis ‐9‐palmitoleic octadecanoic oleic acid. CONCLUSION The protective effect against diabetes closely linked to its regulation microbiota. may serve promising agent for prevention treatment mellitus. © 2025 Society Chemical Industry.

Language: Английский

Citations

The role of fecal microbiota transplantation in diabetes DOI

Gabriele Vassallo, Tommaso Dionisi,

Vittorio De Vita

et al.

Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract Fecal microbiota transplantation (FMT) has emerged as a potential therapeutic strategy for modulating gut dysbiosis in diabetes mellitus. This review critically evaluates preclinical and clinical evidence on FMT type 1 (T1D) 2 (T2D). Studies suggest that can restore microbial diversity, improve glycemic control, modulate immune responses, with varying effects across subtypes. In T1D, models demonstrate influences regulatory T-cell expansion β-cell preservation, though translation remains limited. T2D, shown transient improvements insulin sensitivity, sustained observed only patients specific microbiome signatures. However, heterogeneity patient donor variability, methodological limitations complicate its application. highlights the interplay between FMT, modulation, metabolism, advocating phenotype-stratified trials multi-omics integration to enhance precision.

Language: Английский

Citations

Noncoding RNAs in Host–Microbiota Interaction DOI

Ziyi Zhao, Li Ni,

Jingyi Xu

et al.

Animal Research and One Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT The dynamic interaction between the gut microbiota and host significantly affects biological processes disease progression. In recent years, regulatory mechanisms underlying these intricate interactions have been widely studied. Noncoding RNAs (ncRNAs) are a class of functional that, despite not being translated into proteins, play critical roles in mediating host–gut interactions. this review, we systematically elucidate action influence ncRNAs derived from both hosts microorganisms. Specifically, certain depend on to modulate gene expression function, whereas other can alter composition functionality microbiota. Conversely, bacterial small (sRNAs) infiltrate cells functions genes. These reveal complex communication modes microbiota, providing new perspective for investigating occurrence development intestinal diseases. Consequently, through intervention ncRNAs, host‒microbe dynamics be effectively regulated, thereby potential theoretical technical foundations prevention treatment

Language: Английский

Citations

Chemical composition and in vitro intestinal probiotic properties analysis of exopolysaccharides from screened Streptococcus thermophilus 90301 DOI

Xiaochan Wang, Tao Lin, Yihan Lin

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143882 - 143882

Published: May 2, 2025

Language: Английский

Citations

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease DOI

Guangyi Xu, Yu An,

Yage Du

et al.

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: May 11, 2025

Abstract Epidemiological studies suggest a link between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), possibly due to gut microbiota dysbiosis, although the exact mechanisms are unclear. This narrative review uniquely addresses how microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, amyloidogenesis in T2DM AD, proposing framework for dual therapeutic targeting. provides an in‐depth examination roles their context AD. study indicates that dysbiosis significantly impacts pathogenesis progression both diseases by modulating metabolic pathways, immune functions, inflammatory responses. Key bacteria, such as Akkermansia muciniphila (which releases outer membrane vesicles), Lactobacillus , Bifidobacterium well like short‐chain fatty acids (SCFAs), bile (BAs), lipopolysaccharide (LPS), vitamins, Trimethylamine N‐oxide (TMAO) regulate AD through complex mechanisms. Multiple signaling including G‐protein coupled receptor 41/43 (GPR41/43), phosphoinositide 3‐kinase (PI3K)/protein kinase B (Akt), Toll‐like 4 (TLR4)/nuclear factor kappa‐light‐chain‐enhancer activated cells (NF‐κB), endoplasmic reticulum (ER) stress‐mediated also involved. These findings offer insights into potential targeted therapies

Language: Английский

Citations

Uncovering the pharmacological mechanisms of Patchouli essential oil for treating ulcerative colitis DOI

You Huang,

Pengyu Zhao,

Xing Zhang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118737 - 118737

Published: Aug. 27, 2024

Language: Английский

Citations

Seaweed polysaccharide relieves hexavalent chromium-induced gut microbial homeostasis DOI

Jinghao Mu,

Zhenhuan Guo,

Xiujun Wang

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 16, 2023

Heavy metals released in the environment pose a huge threat to soil and water quality, food safety public health. Additionally, humans other mammals may also be directly exposed heavy or through chain, which seriously threatens health of animals humans. Chromium, especially hexavalent chromium [Cr (VI)], as common metal, has been shown cause serious environmental pollution well intestinal damage. Thus, increasing research is devoted finding drugs mitigate negative effects exposure. Seaweed polysaccharides have demonstrated many pharmacological effects, but whether it can alleviate gut microbial dysbiosis caused by exposure not characterized. Here, we hypothesized that seaweed could exposure-induced poor mice. Mice Cr polysaccharide treatment group was compulsively receive K2Cr2O7. At end experiment, all mice were euthanized, colon contents collected for DNA sequencing analysis. Results showed administration restore reduction diversity Hexavalent significant changes composition mice, including an increase some pathogenic bacteria decrease beneficial bacteria. However, ameliorate microbiota. In conclusion, this study dysbiosis. Meanwhile, lays foundation application polysaccharides.

Language: Английский

Citations