Integrating Machine Learning and Multitargeted Drug Design to Combat Antimicrobial Resistance: A Systematic Review DOI
Nagmi Bano, Salman Arafath Mohammed, Khalid Raza

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 33(3), P. 384 - 396

Published: Nov. 13, 2024

Antimicrobial resistance (AMR) is a critical global health challenge, undermining the efficacy of antimicrobial drugs against microorganisms like bacteria, fungi and viruses. Multidrug (MDR) arises when become resistant to multiple agents. The World Health Organisation classifies AMR bacteria into priority list - I (critical), II (high) III (medium), prompting action from nearly 170 countries. Six bacterial strains account for over 70% AMR-related fatalities, contributing more than 1.3 million direct deaths annually linked 5 globally. Enterobacteriaceae, including Escherichia coli, Salmonella enterica Klebsiella pneumoniae, significantly contribute fatalities. This systematic literature review explores how machine learning (ML) multitargeted drug design (MTDD) can combat in Enterobacteriaceae. We followed PRISMA guidelines comprehensively analysed current prospects limitations by mining PubMed Scopus databases. Innovative strategies integrating AI algorithms with advanced computational techniques allow analysis vast datasets, identification novel targets, prediction mechanisms, optimisation molecules overcome resistance. Leveraging ML MTDD crucial both advancing our fight developing combination therapies that target survival pathways, reducing risk development.

Language: Английский

Fate of antibiotic resistance genes under different wastewater treatments and environmental conditions in an Algerian watershed DOI

Dalal Boulainine,

Aziz Benhamrouche, Elisenda Ballesté

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126179 - 126179

Published: April 1, 2025

Language: Английский

Citations

0
Cold atmospheric‐pressure plasma selectively inhibits glioblastoma via DNA damage and AKT dephosphorylation in vitro and in vivo DOI
Yinan Chen,

Xiaolong Qiao,

Changqing Liu

et al.

Plasma Processes and Polymers, Journal Year: 2024, Volume and Issue: 21(5)

Published: Jan. 17, 2024

Abstract In this work, the effects of cold atmospheric‐pressure plasma (CAP) on glioblastoma are evaluated comprehensively. After CAP treatment, U251 cell viability, migration, and invasion functions were inhibited, while an appropriate dose had no inhibitory effect human brain glial line cells. Western blots indicated that expression caspase‐3 was upregulated with ki‐67 downregulated. Moreover, mitochondrial membrane potential decreased, energy metabolisms cells influenced afterward. TUNEL assays comet suggested DNA damage after treatment. Furthermore, as one responses associated pathways, AKT (AKT8 virus oncogene cellular homolog) signaling pathway also in work. The findings raise great promise for clinical applications treatments.

Language: Английский

Citations

2
Rapid susceptibility of Carbapenem resistant Pseudomonas aeruginosa and its resistance gene to non-thermal plasma treatment in a batch reactor DOI Creative Commons

Thabang B. M. Mosaka,

John Onolame Unuofin, Michael O. Daramola

et al.

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 65, P. 105915 - 105915

Published: Aug. 1, 2024

The critically ranked carbapenem-resistant Pseudomonas aeruginosa has been observed to infect immunocompromised patients that consume polluted waters, leading critical infections and more hospital costs. To save lives unburden the public health sectors of preventable costs, non-thermal plasma (NTP) technology was investigated as an alternative disinfection step could be applied in wastewater treatment plants (WWTPs) inactivate this bacterium its prominent carbapenem resistance gene (blaNDM-1). Culture molecular-based techniques were employed confirm P. (27853). suspensions ATCC (16 h culture) prepared from confirmed isolates subjected at varying time intervals (3 min, 6 9 12 min 15 min) triplicates. treated samples evaluated for re-growth presence blaNDM-1. resulted a 0.68 log reduction after 3 highest ≥8 suggesting great potential efficient tertiary WWTPs. Moreover, gel image showed band intensity blaNDM-1 reduced with time, thereby probable amplified genes. Notwithstanding, longer grounded electrode larger surface (≥ 40 mm diameter) and/or oxygen-containing feeding gas is warranted completely antibiotic (ARG), which might bound by biofilms they seem protect action disinfection.

Language: Английский

Citations

2
Antibiotic resistance and pathogen spreading in a wastewater treatment plant designed for wastewater reuse DOI Creative Commons
Manuela Macrì, Sara Bonetta, Andrea Di Cesare

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125051 - 125051

Published: Sept. 1, 2024

Language: Английский

Citations

2
Antibiotic and Non-Antibiotic Determinants of Antimicrobial Resistance: Insights from Water Ecosystems DOI
Poonam Sharma,

Namrata Pal,

Manoj Kumawat

et al.

ACS ES&T Water, Journal Year: 2024, Volume and Issue: 4(11), P. 4671 - 4689

Published: Oct. 18, 2024

Language: Английский

Citations

2
A Review of the Dissemination of Antibiotic Resistance through Wastewater Treatment Plants: Current Situation in Sri Lanka and Future Perspectives DOI Creative Commons

W. G. N. Gunawardana,

Ruwani S. Kalupahana,

Sanda A. Kottawatta

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1065 - 1065

Published: Aug. 25, 2024

The emergence of antibiotic resistance (AR) poses a significant threat to both public health and aquatic ecosystems. Wastewater treatment plants (WWTPs) have been identified as potential hotspots for disseminating AR in the environment. However, only limited number studies conducted on dissemination through WWTPs Sri Lanka. To address this knowledge gap WWTP operations Lanka, we critically examined global situation transmitting antibiotic-resistant bacteria (ARB) genes (ARGs) by evaluating more than hundred peer-reviewed international publications available national publications. Our findings discuss current state operating country highlight research needed controlling dissemination. results revealed that impact different wastewater types, such clinical, veterinary, domestic, industrial, has not extensively studied Lanka; furthermore, effectiveness various techniques removing ARGs requires further investigation improve technologies. Furthermore, existing explored deeply enough ecological risks posed WWTPs.

Language: Английский

Citations

2
Non-thermal obliteration of critically ranked carbapenem-resistant Acinetobacter baumannii and its resistance gene in a batch atmospheric plasma reactor DOI Creative Commons

Thabang B. M. Mosaka,

John Onolame Unuofin, Michael O. Daramola

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(37), P. 49811 - 49822

Published: July 31, 2024

Abstract Wastewater treatment plants (WWTPs) have been implicated as direct key reservoir of both antibiotic-resistant bacteria (ARB) and genes (ARGs) associated with human infection, high concentrations ARBs ARGs detected in recycled hospital wastewater. Among the ARBs, carbapenem-resistant Acinetobacter baumannii has ranked priority 1 (critical) pathogen by World Health Organization (WHO), due to its overwhelming burden on public health. Therefore, this study is aimed at investigating non-thermal plasma (NTP) technology an alternative disinfection step inactivate bacterium ARGs. Culture-based method PCR were employed confirming carbapenem resistance gene bla NDM-1 A. (BAA 1605). Suspension (24 h culture) was prepared from confirmed isolate subjected varying time intervals (3 min, 6 9 12 15 min) triplicates. The plasma-treated samples evaluated for re-growth presence gene. resulted a 1.13 log reduction after 3 min highest ≥ 8 results also showed that NTP able gel image suggest great potential be efficient tertiary WWTPs.

Language: Английский

Citations

1
Metagenomic insights into plasmid-mediated antimicrobial resistance in poultry slaughterhouse wastewater: antibiotics occurrence and genetic markers DOI
Beatriz Oliveira de Farias, Enrico Mendes Saggioro,

Kaylanne S. Montenegro

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(51), P. 60880 - 60894

Published: Oct. 12, 2024

Language: Английский

Citations

1
Synthesis of an enediyne carbon-allotrope surface for photo-thermal degradation of DNA DOI
Santosh K. Misra, Mao Ye, Parikshit Moitra

et al.

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(90), P. 13434 - 13437

Published: Jan. 1, 2023

The improper disposal of hospital waste products containing genetic materials poses a serious safety threat. We present herein an environmentally friendly technology using graphene-based novel carbon-allotropic surface to remediate such wastes. used carbon-allotrope is decorated with enediyne (EDE-1) enriched aromatic pi-conjugated structure create efficient and active for cleaving DNA strands. Under controlled exposure ultraviolet (UV) radiation heat, the developed influences degradation without disturbing bacterial populations downstream water treatment system. designed material has been extensively characterized physicochemical biological tools. Our results indicate that this approach can possibly be introduced in large scale streams remediating hazards thereby developing portable self-contained

Language: Английский

Citations

1
Recovery of clinically relevant multidrug‐resistant Klebsiella pneumoniae lineages from wastewater in Kumasi Metropolis, Ghana DOI Creative Commons
Amen Ekhosuehi, Odion O. Ikhimiukor, Helen Michelle Korkor Essandoh

et al.

Environmental Microbiology Reports, Journal Year: 2024, Volume and Issue: 16(6)

Published: Nov. 8, 2024

Antimicrobial resistance (AMR) is under-monitored in Africa, with few reports characterizing resistant bacteria from the environment. This study examined physicochemical parameters, chemical contaminants and antibiotic-resistant waste stabilization pond effluents, hospital wastewater domestic four sewerage sites Kumasi. The isolates were sequenced. Three exceeded national guidelines for total suspended solids, biochemical oxygen demand, demand electrical conductivity. Although sulfamethoxazole levels low, antibiotic was detected at all sites. Multi-drug-resistant Klebsiella pneumoniae Pseudomonas aeruginosa isolated multi-locus sequence typing identifying K. strains as ST18 ST147, P. ST235, of clinical relevance. A comparison ST147 genomes human infections Africa showed remarkable similarity shared AMR profiles. Thirteen twenty-one plasmids harbored least one gene, including blaCTX-M-15 linked to copper-resistance genes. Our demonstrated high bacterial counts organic matter analysed wastewater. recovery clinically significant multiple heavy metal genes samples raises public health concerns.

Language: Английский

Citations

0