Intrinsic and Acquired Antimicrobial Resistomes in Plant Microbiomes: Implications for Agriculture and Public Health

Journal of Sustainable Agriculture and Environment, Journal Year: 2025, Volume and Issue: 4(1)

Published: March 1, 2025

ABSTRACT Antimicrobial resistance (AMR) poses a significant threat to both human and environmental health. Before intervention, the natural resistome existed in relatively balanced state, mainly regulated by microbial interactions factors. However, continuous use of antimicrobials other novel entities (chemicals or biological substances) agricultural production clinical settings has resulted huge release residual into environment. This may lead decrease diversity an increase selection pressure. The outcome is alteration with mobile clinically relevant antibiotic genes (ARGs), posing risk In sector, emergence AMR result multiple mechanisms. It involves intricate between activities, factors processes. Direct exposure antibiotic‐resistant bacteria ARGs produce particularly raw eaten vegetables, salad, herbs fruits facilitate spread humans review aims provide comprehensive overview fresh microbiomes. focuses on impact practices risks associated More importantly, this highlights several mitigation strategies future interventions for better understanding ARG transmission within food systems.

Language: Английский

---

Bioaerosols in Agriculture: A Comprehensive Approach for Sustainable Crop Health and Environmental Balance

Agronomy, Journal Year: 2025, Volume and Issue: 15(5), P. 1003 - 1003

Published: April 22, 2025

Bioaerosols have risen as pivotal constituents of airborne particles. Closely intertwined with the agricultural domain, these particles exert a significant influence on crops through dissemination various microorganisms that modulate crop growth dynamics, adaptive responses to environmental stimuli, and nutritional profile products. As main vector, are at forefront in transmission plant pathogens. Therefore, this review explains factors influencing their composition settings spreading. Furthermore, it elucidates complex bioaerosol-based communication networks, including bacteria–bacteria, bacteria–plant, plant–plant interactions, mediated by specialized volatile organic compounds (VOCs) released plants bacterial (BVCs) produced bacteria. These play crucial role synchronizing stress facilitating processes. They serve pathway for regulating behavior both microorganisms. Delving into origin dispersion, we assess key methods collection analysis while also comparing strengths weaknesses sampling techniques. The discussion extends delineating roles such formation biodiversity. Central discourse is an in-depth exploration context, particularly focusing potential utility forecasting pathogen subsequent diseases. This highlights importance applying strategies promotion sustainable practices, thus contributing advancement ecological balance food security, which remains neglected area scientific research.

Language: Английский

---

Surveillance of veterinary drug residues in food commonly consumed in Singapore and assessment of dietary exposure

Heliyon, Journal Year: 2023, Volume and Issue: 9(11), P. e21160 - e21160

Published: Oct. 18, 2023

Non-judicious and indiscriminate use of veterinary drugs in animal husbandry may result accumulation residues tissues, consequently food for human consumption. The abuse presents a potential risk to consumer health, especially if the residue level is higher than health-based guidance value (HBGV) such as acceptable daily intake (ADI). Contamination drug also promotes emergence antimicrobial resistance (AMR) which poses serious threat public health globally. There has been limited information on occurrence dietary exposure Singapore date. In this study, four classes drugs, namely beta-agonists, coccidiostats, fluoroquinolones macrolides, were determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS) widely consumed by residents. magnitude was assessed based consumption profile population. Out 216 samples, 9.72 % detected positive with residues, where majority samples poultry its derived products, followed eggs egg products. 7 specifically ciprofloxacin, enrofloxacin, clopidol, diclazuril, lasalocid, nicarbazin tilmicosin, clopidol enrofloxacin being most frequently drugs. Dietary evaluated estimated (EDI) benchmarked against corresponding All %ADI values far less 100 both average high scenarios, indicating that associated these low.

Language: Английский

---

Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 28, 2024

Abstract Tigecycline is widely used for treating complicated bacterial infections which there are no effective drugs. It inhibits protein translation by blocking the ribosomal A-site. However, even though it also cytotoxic human cells, molecular mechanism of its inhibition remains unclear. Here, we present cryo-EM structures tigecycline-bound mitochondrial 55S, 39S, cytoplasmic 80S and yeast ribosomes. We find that at clinically relevant concentrations, tigecycline effectively targets 55S mitoribosomes, potentially, hindering A-site tRNA accommodation peptidyl transfer center. In contrast, does not bind to ribosomes under physiological concentrations. high in addition A-site, both another conserved binding site restricting movement L1 stalk. conclusion, observed distinct properties may guide new pathways drug design therapy.

Language: Английский

---

Ecological consequences of antimicrobial residues and bioactive chemicals on antimicrobial resistance in agroecosystems

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

---