Bacteria-driven bio-therapy: From fundamental studies to clinical trials DOI
Yuxuan Yu,

Sicen Lin,

Zhichao Chen

et al.

Nano Today, Journal Year: 2022, Volume and Issue: 48, P. 101731 - 101731

Published: Dec. 19, 2022

Language: Английский

Bioleaching of Metals from E-Waste Using Microorganisms: A Review DOI Open Access
Adegoke Isiaka Adetunji, Paul J. Oberholster, Mariana Erasmus

et al.

Minerals, Journal Year: 2023, Volume and Issue: 13(6), P. 828 - 828

Published: June 18, 2023

The rapid and improper disposal of electronic waste (e-waste) has become an issue great concern, resulting in serious threats to the environment public health. In addition, e-waste is heterogenous nature, consisting a variety valuable metals large quantities, hence need for development promising technology ameliorate environmental hazards associated with indiscriminate dumping e-waste, recovery metal components present materials, thus promoting management reuse. Various physico-chemical techniques including hydrometallurgy pyrometallurgy have been employed past mobilization from e-waste. However, these approaches proven be inept due high operational costs linked consumption huge amounts chemicals energy, together loss release secondary byproducts. An alternative method avert above-mentioned limitations adoption microorganisms (bioleaching) as efficient, cost-effective, eco-friendly, sustainable solubilization Metal influenced by microbiological, physico-chemical, mineralogical parameters. This review, therefore, provides insights into strategies or pathways used

Language: Английский

Citations

43

Genetically Engineered Microorganisms and Their Impact on Human Health DOI Creative Commons
Marzie Mahdizade Ari, Leila Dadgar, Z Yad Elahi

et al.

International Journal of Clinical Practice, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 38

Published: March 9, 2024

The emergence of antibiotic-resistant strains, the decreased effectiveness conventional therapies, and side effects have led researchers to seek a safer, more cost-effective, patient-friendly, effective method that does not develop antibiotic resistance. With progress in synthetic biology genetic engineering, genetically engineered microorganisms treatment, prophylaxis, drug delivery, diagnosis been developed. present study reviews types bacteria phages, their impacts on diseases, cancer, metabolic inflammatory disorders, biosynthesis these modified route administration, environment. We conclude can be considered promising candidates for adjunctive treatment diseases cancers.

Language: Английский

Citations

23

Microbial Inoculants in Sustainable Agriculture: Advancements, Challenges, and Future Directions DOI Creative Commons
Alondra María Díaz-Rodríguez, Fannie Isela Parra-Cota,

Luis Alberto Cira Chávez

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(2), P. 191 - 191

Published: Jan. 11, 2025

The rapid growth of the human population has significantly increased demand for food, leading to intensification agricultural practices that negatively impact environment. Climate change poses a significant threat global food production, as it can disrupt crop yields and modify lifecycle stages phytopathogens pests. To address these challenges, use microbial inoculants, which are bioproducts containing beneficial microorganisms known plant promotion (PGPMs), emerged an innovative approach in sustainable agriculture. This review covers isolation identification strains, screening selection process, optimization production techniques, importance quality control field testing. It also discusses key points development formulation high-quality well highlights their advancements, current future directions research application.

Language: Английский

Citations

2

Microbial-Based Heavy Metal Bioremediation: Toxicity and Eco-Friendly Approaches to Heavy Metal Decontamination DOI Creative Commons
Biao Zhou,

Tiejian Zhang,

Fei Wang

et al.

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(14), P. 8439 - 8439

Published: July 21, 2023

There are several industrial processes in which heavy metals used, including but not limited to chrome plating and tanning. Amongst the most toxic human health arsenic, cadmium, chromium, lead, copper, nickel, mercury. The aforementioned possess ability cause contamination upon their release into environment. Humans aquatic terrestrial animals at risk from water soil. Heavy metal toxicity has potential result complications, such as renal hepatic impairment, dermatological afflictions, cognitive lethargy, potentially oncogenic manifestations. removal of wastewater soil can be accomplished using a variety conventional methods, membrane filtration, reverse osmosis, chemical reduction, adsorption. These methods have disadvantages, generating an abundance secondary pollutants, entail significantly higher costs comparison biological methods. Conversely, eco-friendly techniques based on microbes numerous advantages. This review provides comprehensive overview that remove ions, both metabolically dependent independent. Additionally, we also focused source these metals. study is expected particularly beneficial for development treatment systems water.

Language: Английский

Citations

35

The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health DOI
Thi Van Anh Bui, Hyesoo Hwangbo, Y. K. L. Lai

et al.

Korean Circulation Journal, Journal Year: 2023, Volume and Issue: 53(8), P. 499 - 499

Published: Jan. 1, 2023

Cardiovascular diseases (CVDs), including coronary artery disease, stroke, heart failure, and hypertension, are the global leading causes of death, accounting for more than 30% deaths worldwide. Although risk factors CVDs have been well understood various treatment preventive measures established, mortality rate financial burden expected to grow exponentially over time due changes in lifestyles increasing life expectancies present generation. Recent advancements metagenomics metabolomics analysis identified gut microbiome its associated metabolites as potential CVDs, suggesting possibility developing effective novel therapeutic strategies against CVD. In addition, evidence has demonstrated alterations ratio Firmicutes Bacteroidetes imbalance microbial-dependent metabolites, short-chain fatty acids trimethylamine N-oxide, play a crucial role pathogenesis However, exact mechanism action remains undefined this day. review, we focus on compositional related CVDs. Moreover, targeting discussed.

Language: Английский

Citations

29

The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health DOI Creative Commons
Aaron Lerner, Carina Benzvi, Aristo Vojdani

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 238 - 238

Published: Jan. 23, 2024

Gut luminal dysbiosis and pathobiosis result in compositional biodiversified alterations the microbial host co-metabolites. The primary mechanism of bacterial evolution is horizontal gene transfer (HGT), acquisition new traits can be achieved through exchange mobile genetic elements (MGEs). Introducing genetically engineered microbes (GEMs) might break harmonized balance intestinal compartment. present objectives are: 1. To reveal role played by GEMs’ transfers changing landscape enteric microbiome eubiosis 2. expand on potential detrimental effects those changes human genome health. A search articles published PubMed/MEDLINE, EMBASE, Scielo from 2000 to August 2023 using appropriate MeSH entry terms was performed. exchanges induce multiple diseases. GEMs change long-term natural pro- or eukaryotic cell inhabitants. worldwide regulatory authority’s safety control not enough protect public Viability, biocontainment, many other aspects are only partially controlled harmful consequences for health should avoided. It important remember that prevention most cost-effective strategy primum non nocere focus.

Language: Английский

Citations

9

Bacterial Systems as a Precision Delivery Platform of Therapeutic Peptides for Cancer Therapy DOI Creative Commons
Jinyuan Liu, Guizhi Shen, Xuehai Yan

et al.

Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

1

Engineering Useful Microbial Species for Pharmaceutical Applications DOI Creative Commons
А.К. САДАНОВ, B.B. BAIMAKHANOVA,

Saltanat Emilievna Orasymbet

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 599 - 599

Published: March 5, 2025

Microbial engineering has made a significant breakthrough in pharmaceutical biotechnology, greatly expanding the production of biologically active compounds, therapeutic proteins, and novel drug candidates. Recent advancements genetic engineering, synthetic biology, adaptive evolution have contributed to optimization microbial strains for applications, playing crucial role enhancing their productivity stability. The CRISPR-Cas system is widely utilized as precise genome modification tool, enabling enhancement metabolite biosynthesis activation biological pathways. Additionally, biology approaches allow targeted design microorganisms with improved metabolic efficiency potential, thereby accelerating development new products. integration artificial intelligence (AI) machine learning (ML) plays vital further advancing by predicting network interactions, optimizing bioprocesses, discovery process. However, challenges such efficient pathways, ensuring sustainable industrial-scale production, meeting international regulatory requirements remain critical barriers field. Furthermore, mitigate potential risks, it essential develop stringent biocontainment strategies implement appropriate oversight. This review comprehensively examines recent innovations analyzing key technological advancements, challenges, future perspectives.

Language: Английский

Citations

1

Biosorption of heavy metal ions from contaminated wastewater: an eco-friendly approach DOI Creative Commons

Shijie Xie

Green Chemistry Letters and Reviews, Journal Year: 2024, Volume and Issue: 17(1)

Published: May 31, 2024

Several industries such as leather tanning, coal mining, steel and metal processing are responsible for heavy metals contamination in water. Heavy water can have harmful effects on both aquatic terrestrial animals by entering the food chain. Due to higher toxicity of metals, it is necessary remove ions from There several physio-chemical methods available, including ion exchange, membrane filtration, chemical oxidation, electrochemical methods. However, these some disadvantages like expensive generating byproducts. Biosorption a cost-effective eco-friendly method removal contaminated Biosorbents derived biomasses plant, bacterial, algal, fungal, agro-waste, etc. The biosorbents functional groups their surface providing them high binding capacity ions. Mathematical models isotherms, thermodynamics, kinetic studies help explain how adsorb biosorbents. This review provides comprehensive details source, biosorption also mechanism mathematical models.

Language: Английский

Citations

8

The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health DOI Open Access
Aaron Lerner, Carina Benzvi, Aristo Vojdani

et al.

Published: Jan. 3, 2024

Gut luminal dysbiosis and pathobiosis result in compositional biodiversify alterations the microbial host co-metabolites. The main mechanism of bacterial evolution is horizontal gene transfer (HGT) acquisition new traits can be achieved through mobile genetic element (MGEs) exchange. Introducing genetically engineered microbes (GEMs) might break harmonized balance intestinal compartment. present objectives are: 1. To reveal role played by GEMs' transfers changing landscape enteric microbiome eubiosis 2. expand on potential detrimental effects those changes human genome health. A search articles published PubMed/MEDLINE, EMBASE, Scielo from 2000 to august 2023, using appropriate MeSH entry terms were performed. exchanges induce multiple diseases. GEMs change long-term natural pro- or eukaryotic cells inhabitants. worldwide regulatory authority's safety control not enough protect public Viability biocontainment many other aspects are only partially controlled harmful consequences for health should avoided. Always remember that prevention most cost- effective strategy "primum non nocere" name game.

Language: Английский

Citations

5