Bisphenol S impairs oocyte quality by inducing gut microbiota dysbiosis DOI Creative Commons
Jiaming Zhang, Xiaoxia Yu,

Weidong Li

et al.

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

A good quality egg is essential for a successful pregnancy and early embryo development. Oocyte development vulnerable to environmental exposures. Bisphenol S (BPS) widely used as replacement its analog bisphenol A, but the reproductive toxicity of BPS has been great concern. In this study, we showed that exposure induces dysbiosis gut microbiota, which further leads intestinal permeability inflammation, ultimately impairs oocyte quality. More importantly, found alginate oligosaccharide reshapes microbiota improve homeostasis, thereby preventing deleterious effects on oocytes. Overall, study not only demonstrates intestine oocytes by inducing also develops preventive strategy.

Language: Английский

Bisphenol S impairs oocyte quality by inducing gut microbiota dysbiosis DOI Creative Commons
Jiaming Zhang, Xiaoxia Yu,

Weidong Li

et al.

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

A good quality egg is essential for a successful pregnancy and early embryo development. Oocyte development vulnerable to environmental exposures. Bisphenol S (BPS) widely used as replacement its analog bisphenol A, but the reproductive toxicity of BPS has been great concern. In this study, we showed that exposure induces dysbiosis gut microbiota, which further leads intestinal permeability inflammation, ultimately impairs oocyte quality. More importantly, found alginate oligosaccharide reshapes microbiota improve homeostasis, thereby preventing deleterious effects on oocytes. Overall, study not only demonstrates intestine oocytes by inducing also develops preventive strategy.

Language: Английский

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