Pollution-related changes in nest microbiota: Implications for growth and fledging in three passerine birds DOI Creative Commons
L. Leino, Eero J. Vesterinen, Pablo Sánchez‐Virosta

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 357, P. 124434 - 124434

Published: June 25, 2024

Non-ferrous smelters emit toxic metals into the environment, posing a threat to wildlife health. Despite acknowledged role of microbes in host health, impact such emissions on host-associated microbiota, especially wild birds, remains largely unexplored. This study investigates associations metal pollution, fitness, and nest microbiota (serving as proxy for early-life microbial environment) which may influence nestling health development. Our focuses three passerine great tit (Parus major), blue (Cyanistes caeruleus), pied flycatcher (Ficedula hypoleuca), within control metal-polluted sites around Finnish copper-nickel smelter. The polluted had been contaminated with arsenic (As), cadmium (Cd), copper (Cu), nickel (Ni), zinc (Zn). We performed bacterial 16S rRNA sequencing analyses 90 nests monitored body mass, fledging success, various biotic abiotic factors. findings revealed species-specific responses exposure terms both fitness microbiota. P. major C. caeruleus showed sensitivity decreased growth zone. was accompanied by shift community composition, characterized an increase some pathogenic bacteria (in nests) decrease plant-associated (within nests). Conversely, F. hypoleuca their limited indicating greater tolerance pollution-induced environmental changes. Although pollution did not correlate alpha diversity or most abundant taxa across all species, certain potential pathogens were enriched environments negatively correlated parameters. results suggest that alter composition bird either directly indirectly through changes, promoting potentially impacting survival.

Language: Английский

Exploring environmental exposomes and the gut-brain nexus: Unveiling the impact of pesticide exposure DOI
Shing Ching Khoo, Nan Zhang, Vijitra Luang‐In

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 250, P. 118441 - 118441

Published: Feb. 11, 2024

Language: Английский

Citations

5
Variability of faecal microbiota and antibiotic resistance genes in flocks of migratory gulls and comparison with the surrounding environment DOI Creative Commons
Dayana Jarma, Oriol Sacristán‐Soriano, Carles Borrego

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124563 - 124563

Published: July 15, 2024

Gulls commonly rely on human-generated waste as their primary food source, contributing to the spread of antibiotic-resistant bacteria and resistance genes, both locally globally. Our understanding this process remains incomplete, particularly in relation its potential interaction with surrounding soil water. We studied lesser black-backed gull, Larus fuscus, a model examine spatial variation faecal bacterial communities, antibiotic genes (ARGs), mobile genetic elements (MGEs) relationship water soil. conducted sampling campaigns within connectivity network different flocks gulls moving across functional units (FUs), each which represents module highly interconnected patches habitats used for roosting feeding. The FUs vary habitat use, some using more polluted sites (notably landfills), while others prefer natural environments (e.g., wetlands or beaches). Faecal communities from that visit spend time landfills exhibited higher richness diversity. microbiota showed high compositional overlap was greater when compared landfill (11%) than wetland soils (6%), much lower (2% 1% water, respectively). relative abundance ARGs MGEs were similar between FUs, variations observed only specific families MGEs. When exploring carriage bird faeces compartments, gull enriched classified High-Risk. results shed light complex dynamics wild populations, providing insights into interactions among movement feeding behavior, characteristics, dissemination determinants environmental reservoirs.

Language: Английский

Citations

3
Mechanism of action and experimental validation of key genes common to diabetic retinopathy and coronary heart disease based on multiple bioinformatics investigations DOI Creative Commons
Feng Jiang, Shi Yin,

Xinjin Zhang

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Introduction The relationship between diabetic retinopathy (DR) and coronary artery disease (CHD) has been established as a reliable predictor. However, the underlying mechanisms linking these two conditions remain poorly understood. Identifying common key genes could provide new therapeutic targets for both diseases. Methods Public databases were used to compile training validation datasets DR CHD. Machine learning algorithms expression employed identify genes. To investigate immune cell differences, single-sample gene set enrichment analysis (ssGSEA) Wilcoxon test applied. Spearman correlation further explored variations. Additionally, potential drugs targeting identified gene–drug network was constructed. role of in pathogenesis CHD examined through reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Results Consistent trends observed across (GSE221521, GSE113079, GSE189005, GSE42148) led identification HIRIP3 ZNF416 In GSE221521, positively correlated with CD56 bright natural killer cells (cor = 0.329, P < 0.001) type 1T helper 0.327, 0.001), while showed significant correlations CD4 T activation 0.340, 0.273, 0.05). Moreover, 82 transcription factors (TFs) predicted, including SP3. Binding free energy calculations suggested stable binding conformations. RT-qPCR results revealed elevated control group compared (DRwCHD) group, only showing differences groups (p Discussion These findings highlight crucial detection, providing foundation identifying novel

Language: Английский

Citations

0
Dynamic changes in the avian gut microbiome in response to diverse lifestyles DOI
Lingxue Li,

Julan Ye,

Meichen Yu

et al.

Ibis, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

Investigating the intestinal microbiome and its interactions with host is crucial for understanding adaptation mechanisms, functional dynamics co‐evolution of these microbiomes in wild birds. This review examines how gut interact their avian hosts, focusing on establishment microbiomes, dynamic changes occurring throughout different life stages factors that influence microbial variations. It also explores evolutionary relationship between birds symbionts, identifies key areas future research microbes to advance wildlife microbiology.

Language: Английский

Citations

1
The microbiota of long-living and cancer-free blind mole rat $\textit{(Nannospalax xanthodon)}$ from the edge of its distribution in Northern Anatolia DOI Open Access
Halil Mert Solak, Efe Sezgın, Dagmar Čížková

et al.

Communications Faculty of Science University of Ankara Series C Biology Geological Engineering and Geophysical Engineering, Journal Year: 2023, Volume and Issue: 32(2), P. 105 - 118

Published: June 24, 2023

The mammalian gut is colonized by microorganisms that affect development, immune system, energy metabolism, and reproduction. majority of studies focused on laboratory or domestic animals in artificial setups, leaving the research wild species underrepresented. Anatolian Blind Molerat (hereafter ABMR), $\textit{Nannospalax xanthodon}$, a subterranean rodent receives much attention due to its unique traits, such as tolerance extreme hypoxic stress, resistance cancer, longer lifespan compared similarly sized rodents. In this study, we characterize microbiota ABMR from northernmost geographic distribution using 16S rRNA metabarcoding compare our results with microbiome characteristics few other populations studied previously, well species. barcode dataset revealed approximately 90% comprises Firmicutes Bacteriodota bacterial phyla, typical most mammals. addition, has high abundance performance- longevity-linked families. Overall, generally align previous blind molerats emphasize importance studying natural populations.

Language: Английский

Citations

3
Comparison of fecal microbiota of Little Egret (Egretta garzetta) inhabiting coastal and inland environment DOI Creative Commons
M Zhang, Yaoyin He, Gang Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 14, 2024

Abstract Background The digestive tract of birds contains diverse microbiota that are essential for their health and survival, these gut influenced by a variety factors. To compare the diversity in fecal same bird species different environments, this paper collected feces Little Egret (Egretta garzetta) environmental (soil water) samples from coastal salt water inland freshwater areas to explore how responds environments using 16S rRNA high-throughput sequencing methods. Results main two sampling sites were similar at phylum level. In terms genus level, dominant genera salt-water habitats (SWF) Escherichia-Shigella (14.448%), Enterococcus (10.064%), Vibrio (7.812%), whereas there Sporosarcina (18.241%), Citrobacter (11.987%), Acinetobacter (6.201%), Kurthia (5.725%) (FWF). A few ASVs sharedamong egrets regions. between showed no significant differences α-diversity β-diversity; sites. contrast, most parameters reflecting β-diversity shown be significantly microbiota. composition function, little egret environment relative abundances proportion kegg level 1 functional pathways. But some 2 3 pathways habitats. Moreover, portion classified as opportunistic pathogens detected egrets. Conclusions results study indicate less affected soil water. Considering Vibrio which was more common guts marine fish, it is hypothesized regional related changes food types.

Language: Английский

Citations

0
­­Pollution-Related Changes in Nest Microbiota: Implications for Growth and Fledging in Three Passerine Birds DOI
L. Leino, Eero J. Vesterinen, Pablo Sánchez‐Virosta

et al.

Published: Jan. 1, 2024

Non-ferrous smelters emit toxic metals into the environment, posing a threat to wildlife health. Despite acknowledged role of microbes in host health, impact such emissions on host-associated microbiota, especially wild birds, remains largely unexplored. This study investigates associations metal pollution, fitness, and nest microbiota (serving as proxy for early-life microbial environment) which may influence nestling health development. Our focuses three passerine great tit (Parus major), blue (Cyanistes caeruleus), pied flycatcher (Ficedula hypoleuca), within control metal-polluted sites around Finnish copper-nickel smelter. The polluted had been contaminated with arsenic (As), cadmium (Cd), copper (Cu), nickel (Ni), zinc (Zn). We performed bacterial 16S rRNA sequencing analyses 90 nests monitored body mass, fledging success, various biotic abiotic factors. findings revealed species-specific responses exposure terms both fitness microbiota. P. major C. caeruleus showed sensitivity decreased growth zone. was accompanied by shift community composition, characterized an increase some pathogenic bacteria (in nests) decrease plant-associated (within nests). Conversely, F. hypoleuca their limited indicating greater tolerance pollution-induced environmental changes. Although pollution did not correlate alpha diversity or most abundant taxa across all species, certain potential pathogens were enriched environments negatively correlated parameters. results suggest that alter composition bird either directly indirectly through changes, promoting potentially impacting survival.

Language: Английский

Citations

0
Pollution-related changes in nest microbiota: Implications for growth and fledging in three passerine birds DOI Creative Commons
L. Leino, Eero J. Vesterinen, Pablo Sánchez‐Virosta

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 357, P. 124434 - 124434

Published: June 25, 2024

Non-ferrous smelters emit toxic metals into the environment, posing a threat to wildlife health. Despite acknowledged role of microbes in host health, impact such emissions on host-associated microbiota, especially wild birds, remains largely unexplored. This study investigates associations metal pollution, fitness, and nest microbiota (serving as proxy for early-life microbial environment) which may influence nestling health development. Our focuses three passerine great tit (Parus major), blue (Cyanistes caeruleus), pied flycatcher (Ficedula hypoleuca), within control metal-polluted sites around Finnish copper-nickel smelter. The polluted had been contaminated with arsenic (As), cadmium (Cd), copper (Cu), nickel (Ni), zinc (Zn). We performed bacterial 16S rRNA sequencing analyses 90 nests monitored body mass, fledging success, various biotic abiotic factors. findings revealed species-specific responses exposure terms both fitness microbiota. P. major C. caeruleus showed sensitivity decreased growth zone. was accompanied by shift community composition, characterized an increase some pathogenic bacteria (in nests) decrease plant-associated (within nests). Conversely, F. hypoleuca their limited indicating greater tolerance pollution-induced environmental changes. Although pollution did not correlate alpha diversity or most abundant taxa across all species, certain potential pathogens were enriched environments negatively correlated parameters. results suggest that alter composition bird either directly indirectly through changes, promoting potentially impacting survival.

Language: Английский

Citations

0