Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine DOI Creative Commons

Izabella Sall,

Randi Foxall,

Lindsey Felth

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 12, 2025

The therapeutic benefits of opioids are compromised by the development analgesic tolerance, which necessitates higher dosing for pain management thereby increasing liability drug dependence and addiction. Rodent models indicate opposing roles gut microbiota in tolerance: morphine-induced dysbiosis exacerbates whereas probiotics ameliorate tolerance. Not all individuals develop could be influenced differences microbiota, yet no study design has capitalized upon this natural variation. We leveraged behavioral variation a murine model voluntary oral morphine self-administration to elucidate mechanisms influences Although mice shared similar morphine-driven changes that largely masked informative associations with variability our high-resolution temporal analyses revealed divergence progression best explained sustained antinociception. Mice did not tolerance maintained capacity production short-chain fatty acid (SCFA) butyrate known bolster intestinal barriers promote neuronal homeostasis. Both fecal microbial transplantation (FMT) from donor dietary supplementation significantly reduced independently suppression systemic inflammation. These findings inform immediate therapies extend efficacy opioids.

Language: Английский

Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies DOI Creative Commons
Suki Ha, Xiang Zhang, Jun Yu

et al.

Chinese Medical Journal, Journal Year: 2023, Volume and Issue: 137(1), P. 8 - 20

Published: Nov. 30, 2023

Abstract The intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological status. These intestinal microbiota engage in the fermentation non-digestible nutrients and produce beneficial metabolites regulate homeostasis, metabolism, immune response. disruption microbiota, known as dysbiosis, has been implicated many diseases, including colorectal cancer (CRC). As third most common second leading cause cancer-related death worldwide, CRC poses significant health burden. There is an urgent need for novel interventions reduce incidence improve clinical outcomes. Modulating emerged promising approach prevention treatment. Current research efforts probiotics primarily focus on reducing CRC, alleviating treatment-related side effects, potentiating efficacy anticancer therapy, which key successful translation practice. This paper aims review traditional new interventions, such next-generation postbiotics, context CRC. underlying mechanisms probiotic anti-cancer effects are also discussed, restoration microbial composition, reinforcement gut barrier integrity, induction cell apoptosis, inactivation carcinogens, modulation further evaluates strategy adjuvant therapy boosting chemotherapy immunotherapy. Despite all findings presented studies, evaluation potential risks, optimization delivery methods, consideration intra-patient variability baseline must be thoroughly interpreted before bench-to-bedside translation.

Language: Английский

Citations

12
Exploring the efficacy and mechanism of Bailing capsule to improve polycystic ovary syndrome in mice based on intestinal-derived LPS-TLR4 pathway DOI

Hao-ru Guan,

Bo Li,

Zehua Zhang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 331, P. 118274 - 118274

Published: April 30, 2024

Language: Английский

Citations

4
A comprehensive update on the immunoregulatory mechanisms of Akkermansia muciniphila : insights into active ingredients, metabolites, and nutrient-driven modulation DOI

Lihua Mei,

Jiaxin Wang,

Yanling Hao

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Oct. 16, 2024

Akkermansia muciniphila (A. muciniphila) has gained recognition as a pioneering probiotic, exhibiting considerable potential to enhance immune conditions across both humans and animals. The health benefits of A. are attributed its various components, including outer membrane proteins (PilQ Amuc_1100), secreted (P9 AmTARS), extracellular vesicles, metabolites such SCFAs, ornithine lipids, γ-aminobutyric acid, cobalamin, inosine. dynamic control the mucus layer by plays crucial role in regulating intestinal mucosal immunity. Furthermore, modulates function interacting with macrophages, dendritic cells, T lymphocytes, Paneth cells. Increasing abundance gut through nutritional strategies represents safe effective means augment function. Various polyphenols, oligosaccharides, polysaccharides have been shown elevate levels this bacterium, thereby contributing favorable immunoregulatory outcomes. This paper delves into latest research advancements related probiotic mechanisms provides an overview current understanding how responds nutrients. These insights offer theoretical foundation for utilization immunoregulation.

Language: Английский

Citations

4
Fecal Mucoprotein MUC2 is Decreased in Multiple Sclerosis and is Associated with Mucin Degrading Bacteria DOI
Luke Schwerdtfeger, Federico Montini, Tanuja Chitnis

et al.

Published: Jan. 1, 2025

The gut microbiome is altered in MS and may contribute to disease by disrupting the intestinal barrier. colonic mucus barrier, which primarily composed of mucin protein 2 (MUC2), plays a crucial role providing barrier between epithelial cells microbiome. Disruption barriers has been reported inflammatory bowel (IBD) Parkinson's (PD) but not studied context multiple sclerosis (MS). We investigated tight junction zonulin occludins 1 (ZO-1), MUC2, stool markers (calprotectin) microbiota composition subjects with relapsing progressive MS. MUC2 was decreased both ZO-1 elevated serum stool. Inflammatory typically IBD PD, including calprotectin, were stool, suggesting specificity physiology Microbiota known degrading capacity negatively correlated levels. Taken together, these findings suggest reduced function linked increased bacteria.Funding: This work supported grants from NIH/NINDS R21NS126866, NMSS #FG-2207- 40162, Nancy Davis Race Erase Young Investigator Award, Water Cove Charitable Foundation, Clara E. John H. Ware Jr. Foundation.Declaration Interest: None declare.Ethical Approval: All protocols approved BWH institutional review board (IRB Protocol #: 2017P001169) informed consent obtained every study subject.

Language: Английский

Citations

0
Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine DOI Creative Commons

Izabella Sall,

Randi Foxall,

Lindsey Felth

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 12, 2025

The therapeutic benefits of opioids are compromised by the development analgesic tolerance, which necessitates higher dosing for pain management thereby increasing liability drug dependence and addiction. Rodent models indicate opposing roles gut microbiota in tolerance: morphine-induced dysbiosis exacerbates whereas probiotics ameliorate tolerance. Not all individuals develop could be influenced differences microbiota, yet no study design has capitalized upon this natural variation. We leveraged behavioral variation a murine model voluntary oral morphine self-administration to elucidate mechanisms influences Although mice shared similar morphine-driven changes that largely masked informative associations with variability our high-resolution temporal analyses revealed divergence progression best explained sustained antinociception. Mice did not tolerance maintained capacity production short-chain fatty acid (SCFA) butyrate known bolster intestinal barriers promote neuronal homeostasis. Both fecal microbial transplantation (FMT) from donor dietary supplementation significantly reduced independently suppression systemic inflammation. These findings inform immediate therapies extend efficacy opioids.

Language: Английский

Citations

0