Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
277, P. 116326 - 116326
Published: April 18, 2024
The
available
information
regarding
the
impact
of
antimony
(Sb),
a
novel
environmental
pollutant,
on
intestinal
microbiota
and
host
health
is
limited.
In
this
study,
we
conducted
physiological
characterizations
to
investigate
response
adult
zebrafish
different
concentrations
(0,
30,
300,
3000
µg/L)
Sb
over
period
14
days.
Biochemical
pathological
changes
demonstrated
that
effectively
compromised
integrity
physical
barrier
induced
inflammatory
responses
as
well
oxidative
stress.
Analysis
both
microbial
community
metabolome
revealed
exposure
0
30
µg/L
resulted
in
similar
structures;
however,
300
altered
communities'
composition
(e.g.,
decline
genus
Cetobacterium
an
increase
Vibrio).
Furthermore,
significantly
decreased
levels
bile
acids
glycerophospholipids
while
triggering
inflammation
but
activating
self-protective
mechanisms
such
antibiotic
presence.
Notably,
even
can
trigger
dysbiosis
metabolites,
potentially
impacting
fish
through
"microbiota-intestine-brain
axis"
contributing
disease
initiation.
This
study
provides
valuable
insights
into
toxicity-related
concerning
impacts
aquatic
organisms
with
significant
implications
for
developing
management
strategies.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3619 - 3619
Published: April 11, 2025
The
gut–liver
axis
is
essential
in
animal
disease
and
health.
However,
the
role
of
anti-disease
mechanism
disease-resistant
grass
carp
(DRGC)
derived
from
backcross
female
gynogenetic
(GGC)
male
(GC)
remains
unclear.
This
study
analyzed
changes
gut
histopathology,
fecal
intestinal
microflora
metabolites,
liver
transcriptome
between
GC
DRGC.
Histological
analysis
revealed
significant
differences
DRGC
GC.
In
addition,
microbial
community
analyses
indicated
that
hybridization
induced
microbiome
variation
by
significantly
increasing
proportion
Firmicutes
Bacteroidota
Metabolomic
data
hybridization-induced
metabolic
change
was
probably
characterized
being
related
to
taurocholate
sphinganine
Transcriptome
suggested
enhanced
resistance
primarily
attributed
immune-related
genes
(SHMT2,
GOT1,
ACACA,
DLAT,
GPIA,
TALDO1,
G6PD,
FASN).
Spearman’s
correlation
a
association
microbiota,
genes,
metabolites.
Collectively,
axis,
through
interconnected
microbiome–metabolite–gene
pathway,
may
play
crucial
greater
DRGC,
offering
valuable
insights
for
advancing
cultivation
industry.
Animals,
Journal Year:
2023,
Volume and Issue:
13(15), P. 2503 - 2503
Published: Aug. 3, 2023
As
novel
environmental
contaminants,
MPs
exist
widely
in
the
environment
and
accumulate
organisms,
which
has
become
a
global
ecological
problem.
MP
perturbations
of
organismal
physiology
behavior
have
been
extensively
recorded
aquatic
animals,
but
potential
effects
on
poultry
are
not
well
characterized.
Here,
we
explored
adverse
exposure
growth
performance
gut
microbiota
chickens.
Results
showed
that
chickens
decreased
significantly
during
exposure.
Additionally,
Firmicutes,
Bacteroidota,
Proteobacteria
were
found
to
be
dominant
MP-exposed
chickens,
regardless
health
status.
Although
types
bacteria
did
change,
abundances
some
structure
changed
significantly.
Compared
with
controls,
alpha
diversity
exposed
significant
decrease.
The
results
comparative
analyses
between
groups
levels
1
phyla
(Proteobacteria)
18
genera
dramatically
decreased,
whereas
(Cyanobacteria)
12
increased,
In
summary,
this
study
provides
evidence
impact
microbial
composition
leading
imbalance.
This
may
raise
widespread
public
concern
about
threat
caused
by
contamination,
is
relevant
maintenance
quality
protection
health.
Frontiers in Veterinary Science,
Journal Year:
2023,
Volume and Issue:
10
Published: Dec. 7, 2023
The
objective
of
this
study
was
to
examine
the
effects
dietary
Chinese
herbal
medicine
(CHM)
consisting
Astragalus
membranaceus
(Fisch.)
Bunge
(AMT)
and
Codonopsis
pilosula
(Franch.)
Nannf
(CPO)
extracts
on
growth
performance,
antioxidant
capacity,
immune
status,
intestinal
health
broiler
chickens.
Two
groups
were
formed,
each
six
replicates
12
one-day-old
healthy
male
817
white
feather
broilers.
Broilers
fed
either
a
basal
diet
(CON
group)
or
supplemented
with
500
mg/kg
CHM.
trial
lasted
50
days.
results
showed
that
CHM
supplementation
resulted
in
enhanced
feed
efficiency
capacity
both
serum
liver,
while
it
reduced
uric
acid
endotoxin
levels,
as
well
diamine
oxidase
activity
(p
<
0.05).
Additionally,
treatment
increased
height
jejunum
villi
upregulated
Claudin-1
expression
jejunal
mucosa
accompanied
by
an
increase
mRNA
levels
interleukin-6
(IL-6),
interferon-γ
(IFN-γ),
interferon-β
(IFN-β),
tumor
necrosis
factor-α
(TNF-α),
anti-inflammatory
cytokine
interleukin-10
(IL-10)
presence
caused
proportions
Bacteroidetes
unclassified
Bacteroidales
but
led
decrease
those
Firmicutes
Alistipes
composition
microbiota
correlated
conversion
ratio,
metabolites,
gene
based
Spearman
correlation
analysis.
findings
indicated
consumption
improved
utilization
feed,
pro-inflammatory
cytokines
mucosa,
decreased
level
activities
lactate
dehydrogenase
serum,
which
could
potentially
be
linked
changes
gut
