Synthesis of the pentasaccharide repeating unit with a conjugation-ready linker corresponding to the O-antigenic polysaccharide of Acinetobacter junii strain 65

Carbohydrate Research, Journal Year: 2024, Volume and Issue: unknown, P. 109295 - 109295

Published: Oct. 1, 2024

Language: Английский

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Antimicrobial properties of tomato juice and peptides against typhoidal Salmonella

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(3)

Published: Jan. 30, 2024

ABSTRACT Tomatoes are readily available and affordable vegetables that offer a range of health benefits due to their bioactive molecules, such as antioxidants antimicrobials. In contrast the widely recognized antioxidant properties tomatoes, antimicrobial remain largely unexplored. Here, we present our findings on tomato juice peptides, namely, tomato-derived peptides (tdAMPs), in relation effectiveness against typhoidal Salmonella . Our research has revealed demonstrates significant Typhi, pathogen specifically affects humans is responsible for causing typhoid fever. By employing computational analysis genome sequence, conducting molecular dynamics simulation, performing functional analyses, have successfully identified two tdAMPs, tdAMP-1 tdAMP-2. These tdAMPs demonstrated potent by effectively disrupting bacterial membranes. The efficacy tdAMP-2 shown be more effective than tdAMP-1. been drug-resistant S well hyper-capsular Typhi variants possess hypervirulent characteristics, which presently circulating countries with endemicity. Tomato juice, along uropathogenic Escherichia coli well. This underscores potential viable agents combating certain Gram-negative pathogens. study provides valuable insights into development sustainable public strategies utilize its derivatives lifestyle interventions. IMPORTANCE this study, investigate most consumed vegetables, foodborne pathogens an emphasis deadly human-specific pathogen.

Language: Английский

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Single missense mutations in Vi capsule synthesis genes confer hypervirulence toSalmonellaTyphi

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 3, 2024

Abstract Many bacterial pathogens, including the human exclusive pathogen Salmonella Typhi, express capsular polysaccharides as a crucial virulence factor. Here, through S. Typhi whole genome sequence analyses and functional studies, we found list of single point mutations that make S . hypervirulent. We discovered mutation in Vi biosynthesis enzymes control length or acetylation is enough to create different capsule variants Typhi. All variant strains are pathogenic, but hyper-capsule particularly hypervirulent, demonstrated by high morbidity mortality rates observed infected mice. The hypo-capsule have primarily been identified Africa, whereas distributed worldwide. Collectively, these studies increase awareness about existence establish solid foundation for numerous future on variants, offer valuable insights into strategies combat capsulated bacteria.

Language: Английский

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Capsular polysaccharide structure of Acinetobacter baumannii K58 from clinical isolate MRSN31468

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 546, P. 109307 - 109307

Published: Nov. 6, 2024

Language: Английский

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