The causal relationship between gut microbiota and 2 neoplasms, malignant and benign neoplasms of bone and articular cartilage: A two-sample Mendelian randomization study DOI Creative Commons
Jia Lv,

Xiuyu Qin,

Jiani Wang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(46), P. e40519 - e40519

Published: Nov. 15, 2024

Previous research has demonstrated a close connection between the development of bone neoplasms and variations in abundance specific gut microbiota. It remains unclear, however, how microbiota are causally related. Hence, our study, we aim to clarify this relationship 2 neoplasms, malignant neoplasm articular cartilage (MNBAC) benign (BNBAC), by employing two-sample Mendelian randomization (MR) approach. In single nucleotide polymorphisms (SNPs) from genome-wide association studies-pooled data related were evaluated. The inverse variance weighted was employed as major method for assessing aforementioned causal relationship. Furthermore, horizontal multiplicity evaluated utilizing pleiotropy residual sum outlier MR-Egger intercept test. Finally, MR analysis performed assess reverse causality. Inverse results indicate potential genetic 4 MNBAC, 3 BNBAC. On one hand, Eubacterium eligens group (OR = 0.16, 95% CI 0.04–0.67, P .01), Odoribacter 0.23, 0.06–0.84, .03), Slackia 0.35, 0.13–0.93, .04), Tyzzerella3 0.44, 0.24–0.82, .01) exhibited protective effect against MNBAC. other microbes identified potentially BNBAC, Oscillibacter 0.79, 0.63–0.98, .03) Ruminococcus torques 0.62, 0.39–0.98, .04) regarded strains B, while ruminantium 1.24, 1.04–1.47, .02) considered be risk factor increasing incidence Additionally, not found have with above 7 taxa. Four showed effects on causality providing insights into design future interventions reduce burden neoplasms.

Language: Английский

Exploring the casual association between gut microbiome, circulating inflammatory cytokines and chronic pancreatitis: A Mendelian randomization analysis DOI Creative Commons

Yang Xiao-qiu,

Hao Xu,

Xiaolu Liang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(18), P. e37959 - e37959

Published: May 3, 2024

It has been established that gut dysbiosis contributed to the pathogenesis of digestive disorders. We aimed explore causal relationships between intestinal microbiota, circulating inflammatory cytokines and chronic pancreatitis (CP). Summary statistics genome-wide association studies (GWAS) microbiome was retrieved from MiBioGen study GWAS data 91 CP were obtained catalog. The 2-sample bidirectional Mendelian randomization (MR) analysis performed CP, in which inverse variance weighted (IVW) method regarded as primary approach. To prove reliability estimations, multiple sensitivity analyses utilized. IVW results revealed genetically predicted 2 genera, including Sellimonas Eubacteriumventriosumgroup, plasm C-C motif chemokine 23 (CCL23) level positively associated with risk, while genus Escherichia Shigella, Eubacteriumruminantiumgroup Prevotella9, plasma Caspase 8, Adenosine Deaminase (ADA), SIR2-like protein (SIRT2) level, demonstrated an ameliorative effect on CP. Leave-one-out confirmed robustness aforementioned effects no significant horizontal pleiotropy or heterogeneity instrumental variables detected. However, found identified genera CP-related cytokines. Besides, reverse MR relationship Taken together, our comprehensive offer evidence favor estimated connections 5 genus-level microbial taxa 4 may help reveal underlying

Language: Английский

Citations

0
The Associations between Intestinal Flora and Disease Occurrence Risk: A Systematic Review and Meta-Analysis DOI
Guoheng Jiang, Hongyu Li, Linjun Xie

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Relationship between gut microbiota and breast cancer: a Mendelian randomization analysis of mediating effects based on inflammatory proteins DOI Creative Commons
Haipeng Li, Hui Li, Yuan Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 15, 2024

Abstract Background: Breast cancer is associated with dysbiosis of gut flora. However, the mechanisms how microbiota mediate breast disease are not clear, and exploring possible mediating key to investigating study that contribute development. Methods: A two-sample two-way Mendelian randomization (MR) analysis was employed, publicly available genome-wide association (GWAS) data, investigate role abnormal in It focuses on assessing potential mediation by circulating inflammatory proteins. The primary methodology employed for identifying (GM) examining impact markers variance inverse weighting method, supplemented MR-Egger method weighted median method. This research aims offer novel insights into therapeutic interventions cancer. Result: Seven genera three proteins were determined be protein Fibroblast growth factor 21 levels mediated effect intestinal bacterium Adlercreutzia course 11.1% cases, CD40L receptor microbiotaParabacteroides 9% cases.

Language: Английский

Citations

0
Application of Mendelian randomized research method in oncology research: bibliometric analysis DOI Creative Commons
Jiahao Chen, Yunli Wang, Rongsheng Jiang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 17, 2024

Cancer has always been a difficult problem in the medical field, and with gradual deepening of Genome-wide association studies (GWAS), Mendelian randomization methods have increasingly used to study cancer pathogenesis. In this study, we examine literature on cancer, summarize status research, analyze development trends field.

Language: Английский

Citations

0
The causal relationship between gut microbiota and two neoplasms, malignant and benign neoplasms of bone and articular cartilage: a two-sample mendelian randomization study DOI Creative Commons
Jia Lv,

Xiuyu Qin,

Jiani Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 18, 2024

Abstract Background Previous research has demonstrated a close connection between the development of bone neoplasms and variations in abundance specific gut microbiota. It remains unclear, however, how microbiota are causally related. Hence, our study, we aim to clarify this relationship two neoplasms, malignant neoplasm articular cartilage (MNBAC) benign (BNBAC), by employing two-sample Mendelian randomization (MR) approach. Methods In single nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS)-pooled data related were evaluated. The inverse variance weighted (IVW) was employed as major method for assessing aforementioned causal relationship, while median, MR-Egger, mode, simple mode complementary methods. Furthermore, horizontal multiplicity evaluated utilizing mendelian pleiotropy residual sum outlier (MR-PRESSO) MR-Egger intercept test. Cochran's Q test evaluate heterogeneity “leave-one-out” sensitivity analysis determine reliability causality. Finally, MR performed assess reverse Results IVW results indicate potential genetic 4 MNBAC, 3 BNBAC. On one hand, Eubacterium eligens group (OR = 0.16, 95% CI 0.04–0.67, P 0.01), Odoribacter 0.23, 0.06–0.84, 0.03), Slackia 0.35, 0.13–0.93, 0.04), Tyzzerella3 0.44, 0.24–0.82, 0.01) exhibited protective effect against MNBAC. other three microbes identified potentially BNBAC, Oscillibacter 0.79, 0.63–0.98, 0.03) Ruminococcustorques 0.62, 0.39–0.98, 0.04) regarded strains B, ruminantium 1.24, 1.04–1.47, 0.02) considered be risk factor increasing incidence Additionally, not found have with above 7 taxa. No or study. Conclusion MNBAC revealed Of course, further needs conducted verify findings.

Language: Английский

Citations

0
Bibliometric analysis of global research trends between gut microbiota and breast cancer: from 2013 to 2023 DOI Creative Commons
Xianguang Deng,

Hua Yang,

Lingjia Tian

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 31, 2024

Background Breast cancer is the most prevalent globally and associated with significant mortality. Recent research has provided crucial insights into role of gut microbiota in onset progression breast cancer, confirming its impact on disease’s management. Despite numerous studies exploring this relationship, there a lack comprehensive bibliometric analyses to outline field’s current state emerging trends. This study aims fill that gap by analyzing key directions identifying hotspots. Method Publications from 2013 2023 were retrieved Web Science Core Collection database. The VOSviewer, R language SCImago Graphica software utilized analyze visualize volume publications, countries/regions, institutions, authors, keywords field. Results A total 515 publications included study. journal Cancers was identified as prolific, contributing 21 papers. United States China leading contributors University Alabama at Birmingham productive institution. Peter Bai published papers, while James J. Goedert cited author. Analysis highly literature keyword clustering confirmed close relationship between cancer. Keywords such “metabolomics” “probiotics” have been prominently highlighted analysis, indicating future hotspots interaction metabolites microenvironment microbiota. Additionally, these suggest interest therapeutic potential probiotics for treatment. Conclusion Research expanding. Attention should be focused understanding mechanisms their interaction, particularly metabolite-microbiota-breast crosstalk. These advance prevention, diagnosis, treatment strategies provides assessment trends field, offering valuable perspectives

Language: Английский

Citations

0
The causal relationship between gut microbiota and 2 neoplasms, malignant and benign neoplasms of bone and articular cartilage: A two-sample Mendelian randomization study DOI Creative Commons
Jia Lv,

Xiuyu Qin,

Jiani Wang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(46), P. e40519 - e40519

Published: Nov. 15, 2024

Previous research has demonstrated a close connection between the development of bone neoplasms and variations in abundance specific gut microbiota. It remains unclear, however, how microbiota are causally related. Hence, our study, we aim to clarify this relationship 2 neoplasms, malignant neoplasm articular cartilage (MNBAC) benign (BNBAC), by employing two-sample Mendelian randomization (MR) approach. In single nucleotide polymorphisms (SNPs) from genome-wide association studies-pooled data related were evaluated. The inverse variance weighted was employed as major method for assessing aforementioned causal relationship. Furthermore, horizontal multiplicity evaluated utilizing pleiotropy residual sum outlier MR-Egger intercept test. Finally, MR analysis performed assess reverse causality. Inverse results indicate potential genetic 4 MNBAC, 3 BNBAC. On one hand, Eubacterium eligens group (OR = 0.16, 95% CI 0.04–0.67, P .01), Odoribacter 0.23, 0.06–0.84, .03), Slackia 0.35, 0.13–0.93, .04), Tyzzerella3 0.44, 0.24–0.82, .01) exhibited protective effect against MNBAC. other microbes identified potentially BNBAC, Oscillibacter 0.79, 0.63–0.98, .03) Ruminococcus torques 0.62, 0.39–0.98, .04) regarded strains B, while ruminantium 1.24, 1.04–1.47, .02) considered be risk factor increasing incidence Additionally, not found have with above 7 taxa. Four showed effects on causality providing insights into design future interventions reduce burden neoplasms.

Language: Английский

Citations

0