Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 26, 2024
With
the
increasing
number
of
people
with
HIV
(PWH)
and
use
antiretroviral
treatment
(ART)
for
PWH,
has
gradually
become
a
chronic
infectious
disease.
However,
some
infected
individuals
develop
issues
immunologic
non-responses
(INRs)
after
receiving
ART,
which
can
lead
to
secondary
infections
seriously
affect
life
expectancy
quality
PWH.
Disruption
gut
microbiota
is
an
important
factor
in
immune
activation
inflammation
HIV/AIDS,
thus
stabilizing
reduce
promoting
reconstitution
may
direction
HIV/AIDS.
This
paper,
based
on
extensive
literature
review,
summarizes
definition,
mechanisms,
solutions
INRs,
starting
from
perspective
microbiota.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 8, 2024
Abstract
Background
Achieving
complete
immune
reconstitution
(CIR)
in
people
with
human
immunodeficiency
virus
(PWH)
following
antiretroviral
therapy
(ART)
is
essential
for
preventing
acquired
syndrome
(AIDS)
progression
and
improving
survival.
However,
there
a
paucity
of
robust
prediction
models
determining
the
likelihood
CIR
PWH
after
ART.
We
aimed
to
develop
validate
model
utilizing
baseline
data.
Methods
Data
including
demographic
information,
immunological
profiles,
routine
laboratory
test
results,
were
collected
from
Yunnan,
China.
The
participants
divided
into
training
validation
sets
(7:3
ratio).
To
construct
accompanying
nomogram,
univariate
multivariate
Cox
regression
analyses
performed.
was
evaluated
using
C-index,
time-dependent
receiver
operating
characteristic
(ROC)
curves,
calibration
clinical
decision
curves
assess
discrimination,
calibration,
applicability.
Results
5
408
included,
38.52%.
analysis
revealed
various
independent
factors
associated
CIR,
infection
route,
marital
status,
CD4+
T
cell
count,
CD4/CD8
ratio.
A
nomogram
formulated
predict
probability
achieving
at
years
4,
5,
6.
demonstrated
good
performance,
as
evidenced
by
an
AUC
0.8
both
sets.
Calibration
curve
high
level
agreement,
significant
positive
yield.
Conclusions
This
study
successfully
developed
performance.
has
considerable
potential
aid
clinicians
tailoring
treatment
strategies,
which
could
enhance
outcomes
quality
life
PWH.
BMC Complementary Medicine and Therapies,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Dec. 24, 2024
Amphetamine-type
stimulant
(ATS)
abuse
is
strongly
associated
with
an
elevated
risk
of
HIV
infection
and
transmission.
Antiretroviral
therapy
(ART)
serves
as
the
primary
approach
for
managing
AIDS
progression.
However,
ATS
diminishes
efficacy
ART
in
HIV/AIDS
patients,
amplifying
vulnerability
to
immunological
non-response
(INR)
ultimately
increasing
incidence
rate
mortality
opportunistic
infections.
Currently,
no
effective
interventions
targeting
INR
exist.
Acupuncture
has
demonstrated
promise
bidirectionally
modulating
body's
immune
response
may
be
beneficial
combined
abuse.
Nevertheless,
further
research
comprehensive
evaluation
are
imperative
substantiate
these
findings.
This
study
a
two-center,
randomized,
non-acupoint
controlled,
single-blind
clinical
trial.
It
will
conducted
two
large
drug
rehabilitation
centers
western
China,
involving
114
patients
receiving
ART.
The
participants
randomly
assigned
either
Transcutaneous
Electrical
Acupoint
Stimulation
(TEAS)
+
group
or
sham-TEAS
group,
1:1
ratio.
Both
groups
receive
48-week
treatment.
outcome
measure
assessed
after
treatment
CD4
T
cell
count.
Secondary
measures
include
reconstitution
efficiency
CD4/CD8
ratio,
CD45RA
CD45RO
counts,
CD28
CD38
CD8
ki67
JC
mitochondrial
membrane
potential
testing,
infections,
PRO
scale.
Adverse
events
occurring
during
observation
period
documented.
investigate
effect
TEAS
on
amphetamine
infection.
Chinese
Clinical
Trial
Registry,
ChiCTR
2300076363.
Registered
October
7,
2023,
https://www.chictr.org.cn/
.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 26, 2024
With
the
increasing
number
of
people
with
HIV
(PWH)
and
use
antiretroviral
treatment
(ART)
for
PWH,
has
gradually
become
a
chronic
infectious
disease.
However,
some
infected
individuals
develop
issues
immunologic
non-responses
(INRs)
after
receiving
ART,
which
can
lead
to
secondary
infections
seriously
affect
life
expectancy
quality
PWH.
Disruption
gut
microbiota
is
an
important
factor
in
immune
activation
inflammation
HIV/AIDS,
thus
stabilizing
reduce
promoting
reconstitution
may
direction
HIV/AIDS.
This
paper,
based
on
extensive
literature
review,
summarizes
definition,
mechanisms,
solutions
INRs,
starting
from
perspective
microbiota.
