Effects of Maternal Fortified Balanced Energy-Protein Supplementation on the Mother-Infant Gut Microbiome: A Sub-Study of the MISAME-III Randomized Controlled Trial DOI Creative Commons
Lishi Deng, Steff Taelman, Matthew R. Olm

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 27, 2023

Abstract Biological pathways, including individual gut microbiome are potential barriers for maternal nutritional supplementation to improvement in infant growth. We evaluated the impact of balanced energy-protein (BEP) during pregnancy and first six months lactation on composition functionality mothers their infants rural Burkina Faso. Our findings reveal that BEP led a significant increase diversity pregnancy. In second trimester, there was notable decrease abundance an Oscillospiraceae species, while postpartum, Bacteroides fragilis increased. identified concerted enriched or depleted microbial pathways associated with supplementation, phosphotransferase system, critical mechanism bacterial carbohydrates uptake, which exhibited enrichment born BEP-supplemented mothers. Despite these observations, intricate biological connections other omics necessitate further analysis fully elucidate underlying comprehensive pathways.

Language: Английский

Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides DOI Creative Commons
Valentina Gallo, Alyexandra Arienzo,

Federica Tomassetti

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 907 - 907

Published: March 16, 2024

A strong correlation between the occurrence of various pathological conditions and intestinal dysbiosis is supported by a range evidence. Vice versa, many pathologies have been shown, in turn, to be responsible for alterations gut microbiota, condition that can worsen illness outcomes response therapies. For these reasons, great efforts made, studies are still ongoing, elucidate mechanisms underlying microbiota search pharmacologic or other strategies effectively restore microbiota. In this narrative review, we examined most significant literature on role some milk bioactive compounds, such as oligosaccharides whey proteins, modulating composition action, with aim investigating impact changes mediated molecules human health, their potential use therapeutics treat adjuvate treatment associated pathologies.

Language: Английский

Citations

15
Lactopontin regulates gut microbiota and calcium absorption to promote bone growth in growing rats DOI
Y. F. Lyu,

Jianqiang Hu,

Xinyan Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140557 - 140557

Published: Jan. 31, 2025

Language: Английский

Citations

1
Maternal Protein Restriction Impairs Intestinal Morphophysiology and Antioxidant System in Young Male Offspring Rats DOI

Isabel Cristina França dos Santos,

Matheus Naia Fioretto, Miguel Jorge

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: 446(1), P. 114464 - 114464

Published: Feb. 20, 2025

Language: Английский

Citations

0
Influence of gut microbiota on the pediatric endocrine system and associated disorders DOI Open Access
Karan Shah, Alina Sami Khan, Digbijay Kunwar

et al.

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(4), P. 2149 - 2162

Published: March 27, 2025

Language: Английский

Citations

0
Human Milk Components and the Infant Gut Microbiome at 6 Months: Understanding the Interconnected Relationship DOI Creative Commons
Maryam Kebbe, Kartik Shankar, Leanne M. Redman

et al.

Journal of Nutrition, Journal Year: 2024, Volume and Issue: 154(4), P. 1200 - 1208

Published: March 3, 2024

Language: Английский

Citations

3
Compendium of lactopontin: Molecular Structure, Manufacturing Process and Biological Functions DOI
Y. F. Lyu, Xin Wen,

Jianqiang Hu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106155 - 106155

Published: Feb. 1, 2025

Language: Английский

Citations

0
Challenges and Opportunities in Quantifying Bioactive Compounds in Human Breastmilk DOI Creative Commons
Amna Ghith, Reza Maleki, Luke E. Grzeskowiak

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 325 - 325

Published: Feb. 24, 2025

Breastmilk is a complex biological fluid containing over thousand bioactive proteins, lipids, cells and small molecules that provide nutrition immunological protection for infants children. The composition of breastmilk unique to each individual can also vary within individuals according breastfeeding duration, maternal health, time day, other factors. As such, the be considered “fingerprint” could interrogated identify biomarkers breast health disease. However, accurate quantification components in remains significant challenge. Approaches such as immunoassays mass spectrometry have been largely applied study blood or fluids require validation optimisation before these techniques used accurately quantify compounds breastmilk. Development protocols specific should carried out with high precision, confidence, sensitivity. This review explores challenges opportunities associated different components.

Language: Английский

Citations

0
Co-variation of Host Gene Expression and Gut Microbiome in Intestine-Specific Spp1 Conditional Knockout Mice DOI Creative Commons
Na Li, Guangqi Gao, Tao Zhang

et al.

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(6)

Published: May 6, 2025

Osteopontin, which is a highly phosphorylated and glycosylated acidic secreted protein encoded by the phosphoprotein 1 (Spp1) gene, plays crucial role in immune regulation, inflammatory responses, cell adhesion. However, its impact on intestinal gene expression gut microbiota remains underexplored. In this study, we developed an Spp1 conditional knockout mouse model to investigate alterations transcriptome microbiome, with particular emphasis changes predicted metabolic pathways. Our findings demonstrated that significantly modified of genes involved regulation lipid metabolism. Moreover, metagenomic analysis revealed marked shifts microbial diversity pathways associated digestion, absorption, These results suggest instrumental maintaining equilibrium regulating host metabolism responses. This study offers new insights into host-microbiota interactions potential foundations for developing related therapeutic strategies.

Language: Английский

Citations

0
Effects of Maternal Fortified Balanced Energy-Protein Supplementation on the Mother-Infant Gut Microbiome: A Sub-Study of the MISAME-III Randomized Controlled Trial DOI Creative Commons
Lishi Deng, Steff Taelman, Matthew R. Olm

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 27, 2023

Abstract Biological pathways, including individual gut microbiome are potential barriers for maternal nutritional supplementation to improvement in infant growth. We evaluated the impact of balanced energy-protein (BEP) during pregnancy and first six months lactation on composition functionality mothers their infants rural Burkina Faso. Our findings reveal that BEP led a significant increase diversity pregnancy. In second trimester, there was notable decrease abundance an Oscillospiraceae species, while postpartum, Bacteroides fragilis increased. identified concerted enriched or depleted microbial pathways associated with supplementation, phosphotransferase system, critical mechanism bacterial carbohydrates uptake, which exhibited enrichment born BEP-supplemented mothers. Despite these observations, intricate biological connections other omics necessitate further analysis fully elucidate underlying comprehensive pathways.

Language: Английский

Citations

1