Dynamics of antimicrobial resistance and virulence of Salmonella enterica serovar Dublin

Published: Nov. 11, 2024

Salmonella Dublin is a host-adapted, invasive non-typhoidal (iNTS) serovar that causes bloodstream infections in humans and demonstrates increasing prevalence of antimicrobial resistance (AMR). Here, we characterised global population 1,303 S . isolates for virulence mechanisms using combined approach silico vitro analyses. We observed distinct populations Vi antigen-negative S. circulating different geographical regions, with the emergence North American cluster ∼60 years ago. Further, identified two lineages Australia, within which discovered novel hybrid plasmid encoding both AMR mercuric resistance, highlighting potential emerging virulent resistant lineages. These differences, addition to lack flagella represent adaptation may enhance survival pathogenicity, turn affect prevention control strategies future infections. Collectively, our study embodies one most comprehensive investigations highlights impact pathogen on health economic burdens experienced by sectors including livestock human health.

Language: Английский

Genomic analysis of Salmonella isolated from surface water and animal sources in Chile reveals new T6SS effector protein candidates

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 11, 2024

Type VI Secretion Systems (T6SS), widely distributed in Gram-negative bacteria, contribute to interbacterial competition and pathogenesis through the translocation of effector proteins target cells.

Language: Английский