Tissue Engineering Part B Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
Epicatechin
(EC)-based
derivatives
have
garnered
significant
attention
for
their
powerful
antioxidant,
anti-inflammatory,
anticancer,
and
antibacterial
properties,
all
of
which
are
attributed
to
the
phenolic
hydroxyl
groups
in
structure.
These
compounds
promising
regenerative
medicine,
particularly
as
bioactive
components
scaffolds.
This
review
provides
an
in-depth
analysis
mechanisms
by
EC-based
materials
enhance
tissue
repair,
examining
application
various
scaffold
forms,
such
hydrogels,
nanoparticles,
nanofibers.
study
also
addresses
challenges
stability
bioavailability
associated
with
ECs
proposes
encapsulation
techniques
overcome
these
barriers.
The
potential
clinical
benefits
medicine
role
fostering
advancements
engineering
discussed,
making
this
a
valuable
resource
guiding
future
studies
on
integration
into
practice.
Separations,
Journal Year:
2024,
Volume and Issue:
11(1), P. 35 - 35
Published: Jan. 19, 2024
Global
food
waste
has
a
huge
impact
on
the
environment,
as
it
is
source
of
greenhouse
gas
emissions
and
wasted
natural
resources.
Across
world,
over
30%
lost
or
each
year.
Aside
from
this,
industry,
well,
one
biggest
sources
agro-industrial
by-products,
which
can
be
valorized
used
for
different
purposes.
Such
good
bioactive
organic
compounds
that
extracted
without
altering
their
properties,
where
deep
eutectic
solvents
serve
green
an
excellent
replacement
volatile
solvents.
Isolated
in
innovative
production,
chemical
cosmetics
other
industries.
Deep
have
attracted
extraordinary
attention
due
to
advantages
such
environmental
friendliness,
availability
easy
preparation,
handling
utilization
non-toxic
components
formation.
Due
these
they
are
greener
alternative
classic
many
processes,
including
extractions.
In
this
paper,
we
review
potential
media
extraction
polyphenols,
carbohydrates,
proteins
alkaloids
by-products
industry
waste.
Plants,
Journal Year:
2024,
Volume and Issue:
13(15), P. 2133 - 2133
Published: Aug. 1, 2024
This
review
investigates
innovative
strategies
for
upcycling
agricultural
residues
into
valuable
pharmaceutical
compounds.
The
improper
disposal
of
contributes
to
significant
environmental
issues,
including
increased
greenhouse
gas
emissions
and
ecosystem
degradation.
Upcycling
offers
a
sustainable
solution,
transforming
these
high-value
bioproducts
(antioxidants,
antitumor
agents,
antidiabetic
compounds,
anti-inflammatory
antiviral
drugs).
Nanotechnology
microbial
biotechnology
have
crucial
role
in
enhancing
bioavailability
targeted
delivery
bioactive
Advanced
techniques
like
enzymatic
hydrolysis,
green
solvents,
microwave
processing,
pyrolysis,
ultrasonic
acid
alkaline
ozonolysis,
organosolv
processes
are
explored
their
effectiveness
breaking
down
waste
extracting
Despite
the
promising
potential,
challenges
such
as
variability
residue
composition,
scalability,
high
costs
persist.
emphasizes
need
future
research
on
cost-effective
extraction
robust
regulatory
frameworks
ensure
safety,
efficacy,
quality
bioproducts.
represents
viable
path
towards
management
production
contributing
conservation
public
health
improvements.
provides
an
analysis
current
literature
identifies
knowledge
gaps,
offering
recommendations
studies
optimize
use
drug
industry.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 456 - 456
Published: April 12, 2024
Oxidative
stress
is
pivotal
in
the
pathology
of
many
diseases.
This
study
investigated
antioxidant
phytochemistry
avocado
(Persea
americana
Mill.)
peel.
Different
solvent
extracts
(dichloromethane,
ethyl
acetate,
methanol,
and
water)
peel
were
subjected
to
total
phenol
flavonoid
quantification,
as
well
vitro
radical
scavenging
ferric
reducing
evaluation.
The
methanol
extract
was
gradient
column
chromatographic
fractionation.
Fraction
8
(eluted
with
hexane:chloroform:methanol
volume
ratio
3:6.5:0.5,
respectively)
LC-MS
analysis.
It
assessed
for
cellular
inhibition
lipid
peroxidation
lipopolysaccharide
(LPS)-induced
ROS
NO
production.
DPPH
mechanism
chlorogenic
acid
using
Density
Functional
Theory
(DFT).
fraction
had
highest
content
activity.
Chlorogenic
(103.5
mg/mL)
1-O-caffeoylquinic
(102.3
most
abundant
phenolics
fraction.
dose-dependently
inhibited
(IC50
=
5.73
6.17
µg/mL)
15.9
9.34
FeSO4-induced
peroxidation,
LPS-induced
39.6
28.2
63.5
107
production,
while
modulating
enzyme
not
cytotoxic.
DFT
analysis
suggest
that
an
electron
transfer,
followed
by
proton
transfer
at
carbons
3′OH
4′OH
positions
may
be
acid.
Considering
this
bioassay-guided,
it
logical
conclude
strongly
influences
capacity
fruit
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 200 - 200
Published: Jan. 7, 2025
Borneo,
the
third-largest
island
in
world,
is
shared
between
Malaysia
(Sabah
and
Sarawak),
Indonesia
(Kalimantan)
Brunei.
As
a
biodiversity
hotspot,
it
home
to
about
15,000
flowering
plants
3000
tree
species,
of
which
many
are
endemic
region.
Locally
derived
plant-based
foods
gaining
popularity
due
their
lower
environmental
impact,
contribution
food
sustainability
health
benefits.
The
local
fruits
vegetables
Borneo
have
been
used
traditionally
by
indigenous
community
for
medicinal
purposes.
This
knowledge
can
provide
valuable
guide
potential
use
as
functional
foods.
review
explores
contemporary
from
including
fruit,
vegetables,
seaweeds
plant-derived
products
that
locally
consumed.
findings
show
unique
tropical
groups
wide
diversity
phytochemical
compositions
possess
array
biological
activities
anti-inflammatory,
antioxidant,
anti-microbial,
anti-proliferative,
anti-fungal,
wound
healing
expectorant
properties.
range
deserves
further
development
wider
applications
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 512 - 512
Published: Jan. 9, 2025
Navelina
oranges
(Citrus
sinensis)
are
rich
in
phytonutrients
and
bioactive
compounds,
especially
flavonoids
like
hesperidin.
This
study
investigates
the
anti-inflammatory
anti-fibrotic
properties
of
hesperidin
(HE)
a
polyphenol
mixture
from
(OE)
human
hepatocytes
(Hepa-RG)
hepatic
stellate
cells
(LX-2),
order
to
elucidate
underlying
molecular
mechanisms.
In
Hepa-RG
cells,
HE
treatment
increased
expression
cannabinoid
receptor
2
(CB2R),
which
was
associated
with
down-regulation
p38
mitogen-activated
protein
kinases
(p38
MAPK)
but
had
minimal
impact
on
cyclooxygenase-2
(COX-2)
transforming
growth
factor-β
(TGF-β)
levels.
Conversely,
OE
not
only
enhanced
CB2R
levels
reduced
MAPK,
also
promoted
significant
reduction
both
COX-2
TGF-β
levels,
suggesting
that
might
be
more
effective
mitigating
inflammatory
fibrotic
processes
than
HE.
LX-2
caused
notable
decrease
reflecting
its
efficacy
targeting
fibrosis-associated
inflammation.
treatment,
other
hand,
Nuclear
Factor-Kappa
B
p65
(NF-κB)
expression,
critical
transcription
factor
involved
responses,
though
it
did
significantly
affect
COX-2.
induced
fibrosis
treated
showed
several
markers.
addition,
antioxidant
effects
by
increasing
Cu,
Zn
superoxide
dismutase
(SOD1),
Mn
(SOD2)
catalase
(CAT)
influencing
state
lipid
peroxidation.
Further
research
is
needed
explore
treatments
activated
vivo
liver
disease
models.
