World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(12)
Published: Nov. 2, 2024
Language: Английский
Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 1199 - 1219
Published: April 1, 2024
Aim: Scutellaria baicalensis , a traditional Chinese medicinal herb renowned for its anti-inflammatory, antioxidant, and anti-tumor properties, has shown promise in alleviating cognitive impairment associated with Alzheimer's disease. Nonetheless, the exact neuroprotective mechanism of against disease remains unclear. In this study, network pharmacology was employed to explore possible mechanisms by which protects Methods: The active compounds were retrieved from TCMSP database, their corresponding targets identified. disease-related obtained through searches GeneCards OMIM databases. Cytoscape 3.6.0 software utilized construct regulatory illustrating "active ingredient-target" relationships. Subsequently, target genes affected context input into String database establish PPI network. GO analysis KEGG conducted using DAVID predict potential pathways these key targets. Following this, capacity ingredients bind core confirmed molecular docking. vitro experiments then carried out further validation. Results: A total 36 screened out, corresponded 365 Molecular docking results demonstrated robust binding abilities Baicalein, Wogonin, 5,2'-Dihydroxy-6,7,8-trimethoxyflavone proteins (SRC, PIK3R1, STAT3). showed that components can inhibit STAT3 expression downregulating PIK3R1/SRC pathway Neuro 2A cells. Conclusion: summary, findings collectively suggest holds as viable treatment option Keywords: disease, pharmacology,
Language: Английский
Citations
6
Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1416 - 1416
Published: April 19, 2025
Cyclophosphamide (CTX) is a widely used anticancer drug in clinical practice; however, its administration can lead to gastrointestinal damage and immune suppression. Lactobacillus murinus (L. murinus) has been shown regulate cell activity protect the system, showing potential application as functional food. The objective of this study was investigate effects L. ZNL-13 on CTX-induced intestinal mucosal injury gut microbiota mice. results demonstrated that significantly alleviated weight loss pathological damage. Moreover, mice, enhanced release factors, suppressed apoptosis, protected barrier. Additionally, it activated TLR4/NF-κB pathway, thereby promoting activity. Furthermore, contributed restoration microbial homeostasis by increasing relative abundance short-chain fatty acid-producing bacteria. Taken together, investigation highlights protecting barrier enhancing function while laying groundwork for development novel probiotic
Language: Английский
Citations
0
Animals, Journal Year: 2024, Volume and Issue: 14(15), P. 2149 - 2149
Published: July 24, 2024
The dietary crude protein level could affect ruminal fermentation parameters and the microflora of ruminants. present study's aim was to investigate effects different diets on morphology, parameters, digestive enzyme activity, metabolites Tibetan sheep. Ninety weaned lambs (initial weight 15.40 ± 0.81 kg, 2 months old) were selected randomly divided into three groups (six pens/treatment, five rams/pen). Dietary treatments formulated with 13.03% (high protein, HP), 11.58% (moderate MP) 10.20% (low LP), respectively. Compared LP, both papillae length width significantly promoted in HP MP (
Language: Английский
Citations
3
World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(12)
Published: Nov. 2, 2024
Language: Английский
Citations
0