Published: Jan. 1, 2024
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116420 - 116420
Published: March 11, 2024
Gut microbiome alterations are associated with various cancers including brain tumours such as glioma and glioblastoma. The gut communicates the via a bidirectional pathway known gut-brain axis (GBA) which is essential for maintaining homeostasis. microbiota produces many metabolites short chain fatty acids (SCFAs) amino glutamate, glutamine, arginine tryptophan. Through modulation of these able to regulate several functions cells, immune cells tumour DNA methylation, mitochondrial function, aryl hydrocarbon receptor (AhR), T-cell proliferation, autophagy even apoptosis. Here, we summarise current findings on respect cancers, an area research that widely overlooked. Several studies investigated relationship between tumours. However, it remains unclear whether variation cause or product cancer. Subsequently, biomarker panel was constructed use predictive, prognostic diagnostic tool multiple glioblastoma multiforme (GBM). This review further presents intratumoural microbiome, fascinating microenvironment within possible treatment target can be manipulated maximise effectiveness personalised therapy. Studies utilising therapeutic strategy necessary accurately assess clinical cancers.
Language: Английский
Citations
10
Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 139 - 139
Published: Jan. 24, 2025
This study investigated the anti-amnesic effects of Lactobacillus gasseri (L. gasseri) MG4247 and Lacticaseibacillus rhamnosus rhamnosus) MG4644 in amyloid beta (Aβ)-induced mice. We confirmed that oral administration L. ameliorated cognitive impairment Aβ-induced mice using Y-maze, passive avoidance, Morris water maze tests. Oral protected antioxidant system by regulating superoxide dismutase levels, reduced glutathione malondialdehyde contents. Similarly, they attenuated mitochondrial function decreasing reactive oxygen species levels increasing membrane potential ATP levels. In addition, regulated neuroinflammation neurotoxicity modulating Toll-like receptor 4 (TLR4)/protein kinase B (Akt) pathway. As a result, enhanced synaptic acetylcholine contents, acetylcholinesterase activity, expression synaptic-function-related proteins such as AChE, ChAT, SYP, PSD-95, GAP-43. Furthermore, improved dysbiosis promoting growth beneficial bacteria while suppressing harmful bacteria. Therefore, these results suggest may be used probiotics to prevent impairment.
Language: Английский
Citations
1
Medicine, Journal Year: 2025, Volume and Issue: 104(7), P. e41536 - e41536
Published: Feb. 14, 2025
The gut-disc axis, which refers to the interaction between gut microbiota and bone health, has recently garnered widespread attention in scientific community. However, it remains be determined whether directly induces cervical spondylosis (CS). This study employed a bidirectional 2-sample Mendelian randomization (MR) analysis explore potential causal link CS. We initially used inverse variance weighted method for preliminary estimation supplemented with other MR methods, including MR-Egger, median, mode, simple mode. Furthermore, we utilized Cochrane Q test, MR-PRESSO global MR-Egger intercept test assess possible pleiotropy heterogeneity. Ultimately, conducted investigate reverse associations identified 27 significantly associated CS, of 12 may contributing factors, while 15 have protective effects. further revealed relationship CS 24 microbiota. In this study, no significant heterogeneity or was detected. Through analysis, uncovered providing new perspectives prevention treatment especially modulation
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: March 6, 2025
Background Recent research on the gut-brain axis has deepened our understanding of correlation between gut bacteria and neurological system. The inflammatory response triggered by microbiota may be associated with neurodegenerative diseases. Additionally, impact emotional state, known as “Gut-mood” relationship, could play a role in depression anxiety disorders. Results This review summarizes recent data pathophysiology neuropsychiatric disorders including epilepsy, schizophrenia, Alzheimer’s disease, brain cancer, Parkinson’s bipolar disorder stroke. Also, we conducted Mendelian randomization study seven (Epilepsy, stroke). MR-Egger MR-PRESSO tests confirmed robustness analysis against horizontal pleiotropy. Conclusions By comparing protective risk factors for found other researches, can furtherly determine valuable indicators disease evolution tracking potential treatment targets. Future should explore extensive microbiome genome-wide association datasets using metagenomics sequencing techniques to deepen connections causality
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: July 12, 2024
Increasing evidence suggests a robust correlation between the gut microbiome and alopecia areata. In light of extensive diversity microbiota, this study aims to utilize state-of-the-art comprehensive data explore causative association microbiota We conducted Mendelian randomization (MR)-based two-sample elucidate causal relationship Summary information on Ncase = 767 Ncontrol 394,105 cases areata was obtained from FinnGen study. A total 473 microbial taxa were summarized genome-wide (GWAS) catalog. The comprised forward (MR) analysis with as exposure factor outcome, well reverse MR outcome. Various analytical methods including inverse variance weighting (IVW), Weighted Median, MR-Egger, Mode, Simple Mode employed. Subsequently, sensitivity ensure robustness our research findings. This has established Forward revealed causality relationships 16 areata, while found that there may be (not statistically significant). Our findings suggest providing potential guidance for future clinical trials.
Language: Английский
Citations
0
Galician Medical Journal, Journal Year: 2024, Volume and Issue: 31(3)
Published: Aug. 31, 2024
Interest in the microbiome and its correlation with different neurological diseases has grown significantly over past decade. The gut contains a vast array of diverse organisms living gastrointestinal (GI) tract. Predominantly composed bacteria, helps regulate homeostasis metabolism host, aiding immune system development as well vitamin nutrient absorption. Studies suggest that, addition to providing humans these physiological benefits, is also linked communicates brain via gut-brain axis (GBA). Long-standing research on GBA demonstrated that GI tract central nervous are interconnected through both immunological signaling pathways. Recent expanding our understanding GBA, revealing correlations between impact conditions such Alzheimer’s dementia Lewy body dementia, going far identify highlight specific microbial species may serve risk or protective factors for various forms dementia. This letter aims current findings recommend use tools cell-free DNA testing gain better role dysbiosis patients.
Language: Английский
Citations
0
Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3312 - 3312
Published: Sept. 30, 2024
: The causal association of specific gut microbiota with dementia remains incompletely understood. We aimed to access the relationships in which one or more account for dementia.
Language: Английский
Citations
0
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Nov. 27, 2024
Accumulating evidence suggested that Alzheimer's disease (AD) was associated with altered gut microbiota. However, the relationships between microbiota and specific cognitive domains of AD patients have yet been fully elucidated. The aim this study to explore microbial signatures global cognition in determine their predictive value as biomarkers.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0