Characteristics of the Stool, Blood and Skin Microbiome in Rosacea Patients DOI Creative Commons

Marie Isolde Joura,

Antal Jobbágy,

Zsuzsanna A. Dunai

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2667 - 2667

Published: Dec. 23, 2024

Several research groups have confirmed that in the pathogenesis of chronic inflammatory skin disorder rosacea, composition and fecal microbiome affected patients differs from healthy individuals. We studied stool, blood microbiomes rosacea control using 16S rRNA sequencing. Our goals were to determine 1. whether characteristics differ individuals, 2. change experienced on can be by alterations stool through mediation 3. metabolic activity changed skin, or play a role rosacea. The differed significantly both alpha beta diversity, as well abundance genera. Only few genera abundances samples. most significant representatives microbiome, Staphylococcus, Cutibacterium, Corynebacterium Neisseria, cannot derived feces blood. pathways associated with contributed production anti-inflammatory short-chain fatty acids. While increased adenosylcobalamin, L-isoleucine thiazole appeared protective effect, excessive heme H2S likely contribute deterioration pathology.

Language: Английский

Probiotics and gut microbiota modulation: implications for skin health and disease management DOI

Elahe Parhizkar,

Parisa Vosough,

Maryam Baneshi

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(3)

Published: Feb. 23, 2025

Language: Английский

Citations

1
Ocular Rosacea: An Updated Review DOI Creative Commons
Karim Mohamed‐Noriega, Denise Loya-García, Guillermo Raúl Vera-Duarte

et al.

Cornea, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Ocular rosacea is a chronic inflammatory disorder affecting the ocular surface, often associated with cutaneous rosacea. This review aims to explore its pathogenesis, treatment approaches, and future directions for management. A of current literature on pathophysiology, clinical features, strategies in adults children (pediatric blepharokeratoconjunctivitis) was conducted. Emerging research immune dysregulation, microbiome alterations, potential therapeutic targets analyzed. involves dysregulation neurovascular systems, toll-like receptor activation complement system involvement leading surface inflammation. Alterations have been implicated disease progression. Treatment emphasize stepwise approach, incorporating skin hygiene, lifestyle modifications, pharmacological interventions. Recent advancements understanding mechanisms led exploration targeted therapies, including biologics small-molecule inhibitors. remains challenging diagnose treat, particularly blepharokeratoconjunctivitis), delayed intervention poor outcomes. multidisciplinary new options, holds promise improving patient care. Further into genetic molecular basis may enable more personalized treatments.

Language: Английский

Citations

0
Crosstalk Between the Skin Environment and Microbial Community in Immune-Related Skin Diseases DOI
Kecheng Liu,

Shuting Deng,

Yuan Zhou

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 15, 2025

Language: Английский

Citations

0
Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial DOI Creative Commons
Vincenzo Nobile, Cother Hajat, Enza Cestone

et al.

Cosmetics, Journal Year: 2025, Volume and Issue: 12(2), P. 34 - 34

Published: Feb. 22, 2025

Well-aging strategies include the use of both oral and topic products to nourish skin from inside out. A clinical–instrumental study was conducted on 96 Caucasian subjects with mild-to-moderate facial aging demonstrate efficacy probiotic (Lactobacillus plantarum PBS067, Lactobacillus reuteri PBS072, rhamnosus LRH020) intake combined topical ectoin sodium hyaluronate. The sebum content, hydration moisturization, profilometry (wrinkle depth smoothness), TEWL, elasticity (R0 R2 parameters), radiance, pores (size impurities) were measured after 4 8 weeks product use. These parameters also integrated through a self-assessment questionnaire align perceived efficacy. One hour serum application, wrinkle reduced by 9.2%, while increased 16.6% radiance 19.1% following cream application. After use, shown respect skin’s hydrolipid film, effectively improve associated aging, detoxify impurities. mechanism behind these improvements linked an enhancement microbiome. Our findings clearly hyaluronate in enhancing health mitigating signs aging.

Language: Английский

Citations

0
Gut microbiome in dermatology – A narrative review DOI Open Access

Varadraj Vasant Pai,

Aswathy Panikaparambil Sarath,

Zenia Kerkar

et al.

Indian Journal of Dermatology Venereology and Leprology, Journal Year: 2025, Volume and Issue: 0, P. 1 - 11

Published: March 4, 2025

The gut microbiome and human body have co-evolved in a synergistic host-microbial relationship. ideal composition of microbiota is an elusive concept, but every individual has unique profile with regional differences. Newer diagnostic techniques helped identify different bacteria their roles health disease. affected by various factors like age, diet, immune system, environmental factors, exercise, drugs. varied metabolism, response, tolerance antimicrobial protection. Diet plays important role maintaining the microbial diversity. Loss homoeostasis results dysbiosis. Dysbiosis many dermatological diseases atopic dermatitis, psoriasis, acne, rosacea, hidradenitis suppurativa, connective tissue disorders other systemic conditions obesity, diabetes, neurological disease malignancy. Reconstitution ecology form bacteriotherapy reintegration certain strains beneficial these disorders.

Language: Английский

Citations

0
The Bidirectional Relationship Between the Gut Microbiome and Mental Health: A Comprehensive Review DOI Open Access

Kanchanbala Rathore,

Neha Shukla, Sunil G. Naik

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

The gut microbiome plays a fundamental role in mental health, influencing mood, cognition, and emotional regulation through the gut-brain axis. This bidirectional communication system connects gastrointestinal CNS, facilitated by microbial metabolites, neurotransmitters, immune interactions. Recent research highlights association between dysbiosis psychiatric disorders, including anxiety, depression, stress-related conditions. Key findings indicate that altered diversity, decreased short-chain fatty acid (SCFA) production, increased neuroinflammation contribute to health disturbances. paper explores mechanism linking brain function, neurotransmitter synthesis, vagus nerve signaling, hypothalamic-pituitary-adrenal (HPA) axis modulation. Additionally, it evaluates potential of microbiome-targeted interventions, such as probiotics, prebiotics, dietary modifications, fecal microbiota transplantation (FMT), alleviating symptoms. Microbiome sequencing bioinformatics advances further support development personalized microbiome-based interventions. Despite promising evidence, challenges inter-individual variability, methodological inconsistencies, need for longitudinal studies remain. Future should focus on standardizing assessment techniques optimizing therapeutic applications. Integrating precision psychiatry with diagnostics holds immense transforming treatment.

Language: Английский

Citations

0
Recent advances in therapeutic probiotics: insights from human trials DOI
Mu-Yeol Cho,

Jeong-Sik Eom,

Eun-Mi Choi

et al.

Clinical Microbiology Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

SUMMARY Recent advances in therapeutic probiotics have shown promising results across various health conditions, reflecting a growing understanding of the human microbiome’s role and disease. However, comprehensive reviews integrating diverse effects subjects been limited. By analyzing randomized controlled trials (RCTs) meta-analyses, this review provides overview key developments probiotic interventions targeting gut, liver, skin, vaginal, mental, oral health. Emerging evidence supports efficacy specific strains combinations treating wide range disorders, from gastrointestinal (GI) liver diseases to dermatological bacterial vaginosis, mental diseases. We discuss expanding microbiome-organ connections underlying mechanisms action. While many clinical demonstrate significant benefits, we acknowledge areas requiring further large-scale studies establish definitive optimal treatment protocols. The addresses challenges standardizing research methodologies emphasizes importance considering individual variations microbiome composition host genetics. Additionally, explore emerging concepts such as oral-gut-brain axis future directions, including high-resolution profiling, host-microbe interaction studies, organoid models, artificial intelligence applications research. Overall, offers update on current state multiple domains health, providing insights into directions potential for revolutionize preventive medicine.

Language: Английский

Citations

0
Characteristics of Gut Microbiota in Rosacea Patients—A Cross-Sectional, Controlled Pilot Study DOI Creative Commons
Anne Guertler,

Pascal Hering,

Cátia Pacífico

et al.

Life, Journal Year: 2024, Volume and Issue: 14(5), P. 585 - 585

Published: May 1, 2024

Background: Recent studies have suggested a possible connection between rosacea and patients’ gut microbiota. Objective: To investigate the differences in fecal microbial profiles patients with healthy controls. Methods: Gut microbiota of 54 (RP) were analyzed using MiSeq 16S rRNA sequencing. Enterotypes, Firmicutes/Bacteroides (F/B) ratio, significance alpha beta diversity, differential abundance analysis (DAA) calculated compared age- gender-matched controls (CP, n = 50). Results: Significant changes enterotypes F/B ratio observed RP CP (p 0.017 p 0.002, respectively). The showed decreased richness diversity to (Shannon 0.012, inverse Simpson 0.034). Beta also differed both groups (PERMANOVA, 0.006). Fourteen significantly different taxa detected according DAA. Faecalibacterium prausnitzii (coef. −0.0800, 0.008), Lachnoospiraceae ND 3007 group sp. −0.073, < 0.001), Ruminococcaceae −0.072, 0.015) decreased; Oscillobacter 0.023, 0.031), Flavonifractor plautii 0.011, 0.037), Ruminococccaceae UBA 1819 0.010, 0.031) increased CP. Conclusion: alterations present RP. Taxonomic shifts reduced when Larger prospective are needed correlations clinical features translate these findings into future therapeutic approaches.

Language: Английский

Citations

1
Meta‐Analysis of the Efficacy of Intense Pulsed Light and Pulsed‐Dye Laser Therapy in the Management of Rosacea DOI Creative Commons

Qianyu Zhai,

Shaohang Cheng,

Runying Liu

et al.

Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

ABSTRACT Objective The primary aim of this systematic review and meta‐analysis was to synthesize compare the clinical efficacy intense pulsed light (IPL) pulsed‐dye laser (PDL) therapies for management rosacea. Methods literatures were searched in Web Science, PubMed, Embase, Cochrane Library databases identify relevant studies investigating use IPL PDL treatment Screening retrieved articles data extraction performed as per pre‐established inclusion exclusion criteria. outcome measures evaluated included clearance rates, erythema scores, pain scores. Results incorporated from four involving a total 141 participants. did not reveal statistically significant difference between rate achieving greater than 50% (RR = −0.07, 95% CI: −0.19, 0.05). However, group demonstrated significantly higher exceeding 75% compared −0.13, −0.23, −0.04). change index, key measure rosacea severity, similar two modalities (SMD −0.15, −0.55, 0.26). Interestingly, reported notably lower VAS score 1.54, 0.08, 3.00). Conclusion Either or appears be effective exhibits slight advantage substantial (>75%) clearance, while may preferable patients with tolerance post‐treatment discomfort. existing literature directly comparing these laser/light‐based is limited, warranting further well‐designed, large‐scale establish optimal algorithm chronic inflammatory skin condition.

Language: Английский

Citations

1
Ferulic Acid in the Treatment of Papulopustular Rosacea: A Randomized Controlled Study DOI Creative Commons

Xing Wang,

Yitao Xue, Haihui Zhu

et al.

Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

ABSTRACT Background Rosacea is a chronic inflammatory skin disease characterized by flushing, erythema, papules, and pustules on the central face. It affects patient appearance noted for its chronicity, recurrence, resistance to treatment. Effective rosacea treatment requires repairing barrier, reducing inflammation, promoting vasoconstriction. Aims This study aims evaluate efficacy of topical ferulic acid in treating papulopustular impact barrier function. Methods Sixty patients with mild moderate were selected from Department Dermatology at Affiliated Hospital Shandong Second Medical University between January 2023 December 2023. Patients randomly assigned either control group or an observation group, 30 each group. The applied solution affected areas, while used normal saline, both twice daily 6 weeks. Both groups also received 0.1 g doxycycline hydrochloride tablets orally once daily. Skin lesions function assessed using VISIA imaging self‐rating scales before during treatment, adverse reactions recorded. Results After weeks, lesion assessments self‐assessment scores improved significantly baseline, greater improvement compared ( p < 0.05). Indicators results demonstrated rosacea. total effective rate was higher (80.00%) (63.33%) In nine (30.00%) experienced greasy sensation initially, one (3.33%) reported tingling itching, no serious observed. Conclusions Ferulic as adjuvant rosacea, improving minimal reactions.

Language: Английский

Citations

1