Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2667 - 2667
Published: Dec. 23, 2024
Several
research
groups
have
confirmed
that
in
the
pathogenesis
of
chronic
inflammatory
skin
disorder
rosacea,
composition
and
fecal
microbiome
affected
patients
differs
from
healthy
individuals.
We
studied
stool,
blood
microbiomes
rosacea
control
using
16S
rRNA
sequencing.
Our
goals
were
to
determine
1.
whether
characteristics
differ
individuals,
2.
change
experienced
on
can
be
by
alterations
stool
through
mediation
3.
metabolic
activity
changed
skin,
or
play
a
role
rosacea.
The
differed
significantly
both
alpha
beta
diversity,
as
well
abundance
genera.
Only
few
genera
abundances
samples.
most
significant
representatives
microbiome,
Staphylococcus,
Cutibacterium,
Corynebacterium
Neisseria,
cannot
derived
feces
blood.
pathways
associated
with
contributed
production
anti-inflammatory
short-chain
fatty
acids.
While
increased
adenosylcobalamin,
L-isoleucine
thiazole
appeared
protective
effect,
excessive
heme
H2S
likely
contribute
deterioration
pathology.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1360 - 1360
Published: Oct. 25, 2024
There
is
evidence
of
the
effect
probiotic
intake
on
immune
system.
However,
probiotics
may
have
rate
aging
unknown.
The
aim
this
study
to
determine
a
blend
immunity,
redox
state,
inflammation,
and
or
biological
age.
A
group
10
men
14
women
took,
daily
for
2
months,
sachet
with
three
(
Journal of Pharmaceutical Research International,
Journal Year:
2024,
Volume and Issue:
36(3), P. 34 - 46
Published: March 22, 2024
Rosacea
is
a
chronic
inflammatory
dermatological
condition
with
different
clinical
phenotypes,
usually
diagnosed
clinically
and
treated
systemic
topical
medications.
one
of
the
skin
conditions
that
often
believed
to
just
have
cutaneous
manifestation,
but
it
actually
affects
many
systems.
The
correlation
between
rosacea
variety
comorbidities,
including
depression,
gastrointestinal
disorders,
migraines,
autoimmune
conditions,
cardiovascular
diseases
(CVD)
are
noted
in
studies.
There
numerous
risk
factors
for
CVD,
hypertension
(HTN),
diabetes
mellitus
(DM),
metabolic
syndrome
(MS),
dyslipidemia.
CVD
has
high
mortality
rate
should
not
be
overlooked.
patients
must
receive
appropriate
education
regarding
management
addition
rosacea.
We
thought
was
important
conduct
literature
review
investigate
association
associated
CVDs,
since
both
involve
interaction
genetic
factors.
purpose
this
narrative
overview
rosacea,
draw
attention
face,
alert
dermatologists,
cardiologists,
primary
care
physicians
need
immediate
factor
treatment.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 10, 2024
There
is
evidence
from
observational
studies
that
human
microbiota
linked
to
skin
appendage
Disorders
(SADs).
Nevertheless,
the
causal
association
between
and
SADs
yet
be
fully
clarified.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(10), P. 10714 - 10730
Published: Sept. 24, 2024
Chronic
allergic
skin
conditions,
including
atopic
dermatitis
(AD),
are
characterized
by
pruritus,
erythema,
xerosis,
desquamation,
and
inflammation,
significantly
impacting
quality
of
life.
Long-term
steroid
use,
while
common
in
treatment,
carries
the
risk
adverse
effects.
Previous
studies
have
demonstrated
potential
Lactobacillus
paracasei
subsp.
NTU
101
(NTU
101)
alleviating
AD
symptoms
from
a
preventive
perspective.
This
study,
however,
focuses
on
exploring
101’s
therapeutic
investigating
its
effects
regulatory
T
cell
(Treg)
maturation
Th1/Th2
balance.
The
results
revealed
that
administration
effectively
reduced
serum
IgE
levels
inflammatory
infiltration
skin,
leading
to
significant
improvement
both
epidermal
dermal
thickness
model.
Additionally,
modulated
immune
response
increasing
proportion
CD4+/IL-4+
(Th2)
cells
spleen
concurrently
enhancing
FOXP3
expression
CD4+/CD25+
cells,
which
is
critical
for
Treg
development.
modulation
was
further
associated
with
rebalancing
ratio,
achieved
CD4+/IFN-γ+
(Th1)
cells.
Moreover,
influenced
CD4+IL-17+
(Th17)
thereby
supporting
neutrophil
promoting
allergen
clearance,
ultimately
mitigating
symptoms.
These
findings
underscore
not
only
managing
but
also
modulating
key
pathways
involved
pathogenesis
disease,
offering
promising
alternative
or
adjunct
conventional
therapies.
mSystems,
Journal Year:
2024,
Volume and Issue:
9(11)
Published: Oct. 30, 2024
ABSTRACT
Rosacea
is
a
chronic
inflammatory
skin
condition
marked
by
facial
erythema,
telangiectasia,
and
acne-like
eruptions,
affecting
millions
worldwide.
While
antibiotics
remain
common
treatment,
prolonged
use
has
significant
adverse
effects
can
lead
to
antibiotic
resistance.
This
study
evaluated
the
impact
of
combined
probiotics
doxycycline
treatment
on
rosacea,
emphasizing
gut–skin
axis.
Sixty
rosacea
patients
were
randomly
assigned
probiotic,
placebo,
or
control
groups.
After
2-week
participants
underwent
3-month
intervention
with
either
no
further
treatment.
Clinical
outcomes
assessed
at
baseline
after
14-week
intervention.
Our
results
showed
that
probiotic
administration
improved
conditions,
alleviated
inflammation,
reduced
microbiota
diversity
while
enhancing
gut
heterogeneity.
Multivariate
analysis
identified
microbial
markers
distinguishing
group
from
placebo
groups,
some
associated
health
parameters.
intervention,
skin-associated
taxa,
such
as
Aquabacterium
sp.,
UBA4096
sp.
1,
2,
Yimella
indica
,
decreased
in
abundance.
Additionally,
fecal
was
enriched
specific
microbes,
including
Streptococcus
parasanguinis
Erysipelatoclostridium
ramosum
Coprobacillus
cateniformis
showing
abundance
Bacteroides
vulgatus
.
These
changes
sebum
levels
lower
physician’s
global
assessment
score.
Finally,
fewer
resistance
genes,
particularly
tetracycline
detected
compared
supports
existence
axis
application
managing
rosacea.
IMPORTANCE
research
elucidates
management
novel
insights
into
alongside
doxycycline,
dual
benefits
symptom
relief
inflammation
reduction
patients.
The
maps
probiotic-induced
shifts
microbiota,
underscoring
correlating
improvements.
Crucially,
it
deciphers
modulation
probiotics,
proposing
method
curb
therapies.
furnishes
robust
evidence
for
advancing
our
grasp
relationship.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 12, 2024
Introduction
Numerous
factors
influence
hair
health,
including
genetic
predisposition,
hormonal
changes,
stress,
nutritional
deficiencies,
medical
conditions,
or
medications.
With
the
rising
interest
in
maintaining
alternative
approaches
such
as
functional
cosmetics
and
food
products
are
gaining
attention.
Probiotics,
health-beneficial
live
microorganisms,
emerging
potential
candidates
for
improving
health.
Therefore,
this
study
aimed
to
evaluate
effects
safety
of
oral
intake
Latilactobacillus
curvatus
LB-P9
on
Methods
The
was
a
randomized,
double-blind,
placebo-controlled
clinical
trial
involving
participants
(aged
18–60
years
old)
with
mild
moderate
damage.
Participants
were
randomly
assigned
test
(receiving
supplements)
control
placebo)
groups,
respectively.
Efficacy
assessed
using
measures
luster,
elasticity,
participant
satisfaction.
Safety
evaluations
comprised
physical
examinations,
vital
sign
measurements,
laboratory
tests,
observation
adverse
reactions.
Results
Overall,
80
enrolled
trial.
Significant
improvements
observed
satisfaction
group
compared
group.
In
group,
luster
parameter
increased
by
1.65
±
2.30
(L
BNT
)
at
24
weeks
(
p
<
0.001),
indicating
19%
improvement
over
Subgroup
analysis
revealed
significant
among
females
short
hair.
Additionally,
tensile
strength,
reflecting
elasticity
10.27
16.40
(gf/mm
2
=
0.001)
subjective
indicator
satisfaction,
which
improves
survey
scores
decrease,
significantly
decreased
−17.81
14.35
points
after
consuming
than
before
it.
No
reactions
reported,
indicated
no
linked
consumption.
Conclusion
LB-P9,
may
serve
an
management
findings
support
possible
benefits
supplementation
enhancing
elasticity.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2667 - 2667
Published: Dec. 23, 2024
Several
research
groups
have
confirmed
that
in
the
pathogenesis
of
chronic
inflammatory
skin
disorder
rosacea,
composition
and
fecal
microbiome
affected
patients
differs
from
healthy
individuals.
We
studied
stool,
blood
microbiomes
rosacea
control
using
16S
rRNA
sequencing.
Our
goals
were
to
determine
1.
whether
characteristics
differ
individuals,
2.
change
experienced
on
can
be
by
alterations
stool
through
mediation
3.
metabolic
activity
changed
skin,
or
play
a
role
rosacea.
The
differed
significantly
both
alpha
beta
diversity,
as
well
abundance
genera.
Only
few
genera
abundances
samples.
most
significant
representatives
microbiome,
Staphylococcus,
Cutibacterium,
Corynebacterium
Neisseria,
cannot
derived
feces
blood.
pathways
associated
with
contributed
production
anti-inflammatory
short-chain
fatty
acids.
While
increased
adenosylcobalamin,
L-isoleucine
thiazole
appeared
protective
effect,
excessive
heme
H2S
likely
contribute
deterioration
pathology.
