Roles of skin microbiota in hidradenitis suppurativa: insights from a two-sample Mendelian randomization analysis DOI Creative Commons
Chenyang Yu, Yan Wei, Huidi Shucheng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with unique lesional dysbiotic features. However, the role of microbiology in pathogenesis HS remains dispute. We aimed to conduct two-sample Mendelian randomization study investigate relationship between microbiota and HS. A was performed using summary statistics from GWAS data European descent two cross-sectional, population-based German cohorts, KORA FF4 (n = 324) PopGen 273). The hidradenitis were obtained FinnGen DF10 (1,070 cases 394,105 controls). Inverse variance weighted (IVW), MR-Egger regression, median, simple mode, MRPRESSO used examine causal association suppurativa. Cochran’s Q quantify heterogeneity instrumental variables. Our suggested that genus Corynebacterium dry significantly after false discovery rate (FDR) correction (odds ratio (OR) 1.04, 95% confidence interval (CI): 1.02–1.06, P 0.0002, FDR adjusted 0.035). Additionally, we found Micrococcus moist (OR 1.10, CI: 1.03–1.18, 0.0060, 0.360), species Streptococcus salivarius 1.03, 1.01–1.05, 0.0070, Propionibacterium granulosum 1.02, 1.00–1.04, 0.0460, 0.970) are potentially before adjustment. No evidence effect reverse direction for on microbial This causally Further studies needed clarify protective probiotics

Language: Английский

Roles of skin microbiota in hidradenitis suppurativa: insights from a two-sample mendelian randomization analysis DOI
Chenyang Yu, Yan Wei, Huidi Shucheng

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 6, 2025

Language: Английский

Citations

0
Gut microbiome in dermatology – A narrative review DOI Open Access

Varadraj Vasant Pai,

Aswathy Panikaparambil Sarath,

Zenia Kerkar

et al.

Indian Journal of Dermatology Venereology and Leprology, Journal Year: 2025, Volume and Issue: 0, P. 1 - 11

Published: March 4, 2025

The gut microbiome and human body have co-evolved in a synergistic host-microbial relationship. ideal composition of microbiota is an elusive concept, but every individual has unique profile with regional differences. Newer diagnostic techniques helped identify different bacteria their roles health disease. affected by various factors like age, diet, immune system, environmental factors, exercise, drugs. varied metabolism, response, tolerance antimicrobial protection. Diet plays important role maintaining the microbial diversity. Loss homoeostasis results dysbiosis. Dysbiosis many dermatological diseases atopic dermatitis, psoriasis, acne, rosacea, hidradenitis suppurativa, connective tissue disorders other systemic conditions obesity, diabetes, neurological disease malignancy. Reconstitution ecology form bacteriotherapy reintegration certain strains beneficial these disorders.

Language: Английский

Citations

0
Causal relationship and potential common pathogenic mechanisms between hidradenitis suppurativa and related cancer DOI Creative Commons
Zexin Zhu,

Xiaoxue Wang

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 12, 2025

Hidradenitis suppurativa (HS) is a chronic, inflammatory and common skin disease. Observation studies have reported the association between HS cancers, however no whether causal relationship exists cancers. This study aimed to explore differential subtypes of cancers by conducting bidirectional Mendelian randomization (MR) analysis. Genome-wide (GWAS) data related 16 were collected. The inverse variance weighted (IVW) method was primarily applied for our MR analysis, MR-Egger, median, simple mode, mode methods used additionally. Heterogeneity, horizontal pleiotropy, potential outliers assessed analysis results. Subsequently, disease-related genes retrieved from GeneCards database. To investigate functions these associated genes, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses conducted. results indicated pancreatic cancer (PAC). Specifically, found elevate risk developing PAC (odds ratio (OR), 1.074; 95% confidence interval (CI) 1.015–1.135; p = 0.013). Conversely, reverse demonstrated that does not exert effect on HS. Furthermore, findings did reveal any significant relationships other types cancer. No evidence heterogeneity or pleiotropy identified in Additionally, we subsequent GO KEGG both are implicated pathways with immune processes. this offer novel regarding HA PAC. Our indicates may influence PAC, which could inform development improved treatment strategies patients suffering However, underlying mechanisms warrant further exploration.

Language: Английский

Citations

0
An updated safety review of hidradenitis suppurativa treatment options DOI

Ruggero Cascio Ingurgio,

Luciano Ibba,

Ângela Alfano

et al.

Expert Opinion on Drug Safety, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Introduction Moderate-to-severe hidradenitis suppurativa (HS) is a chronic inflammatory condition with significant impact on patients' quality of life. Recent advancements in biologics and small-molecule therapies offer new treatment options by targeting diverse pathways.

Language: Английский

Citations

0
Hidradenitis suppurativa and cardiovascular diseases: A bidirectional Mendelian randomization study DOI Creative Commons

Ping Zhou,

Xin Jiang, Dan Wang

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(7)

Published: July 1, 2024

Abstract Background Prior investigation has indicated a link between Hidradenitis suppurativa (HS) and cardiovascular diseases (CVDs), yet the causal relationship (CR) these conditions remains unresolved. Methods This utilized bidirectional Mendelian randomization (MR) analysis to determine CR HS CVDs. Genetic instruments for both were sourced from genome‐wide association studies (GWAS). The GWAS summary data CVD comprised coronary artery disease (CAD), myocardial infarction (MI), atherosclerosis (CA), ischemic stroke (IS), chronic heart failure (CHF). Four new approaches added inverse variance weighted (IVW) method main analysis: median, MR‐Egger, simple mode, mode. validity of conclusions was verified by sensitivity tests that included leave‐one‐out analysis, heterogeneity, pleiotropy. Results CAD (OR = 1.024; 95%CI: 1.002–1.046, P 0.033), MI 1.001; 1.000–1.002, CA 0.022) identified have positive CR, according IVW analysis. Conversely, no significant either IS or CHF. Furthermore, reverse causation diseases. Conclusion findings this study suggest potential CAD, MI, CA. Additional research is warranted elucidate biological mechanisms underlying associations.

Language: Английский

Citations

1
Follicular Skin Disorders, Inflammatory Bowel Disease, and the Microbiome: A Systematic Review DOI Open Access
Lauren Fleshner, Katie Roster, Banu Farabi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10203 - 10203

Published: Sept. 23, 2024

Follicular skin disorders, including hidradenitis suppurativa (HS), frequently coexist with systemic autoinflammatory diseases, such as inflammatory bowel disease (IBD) and its subtypes, Crohn’s ulcerative colitis. Previous studies suggest that dysbiosis of the human gut microbiome may serve a pathogenic link between HS IBD. However, role (gut, skin, blood) in context IBD various follicular disorders remains underexplored. Here, we performed systematic review to investigate relationship IBD, microbiome. Of sixteen included studies, four evaluated impact diet on patients, highlighting possible yeast-exclusion diets. Ten explored bacterial colonization severity specific microbiota, Enterococcus Veillonella. Two reported immunological or serological biomarkers patients disease, identified common markers elevated cytokines T-lymphocytes. Six investigated concurrently. Our literature highlights complex interplay microbiome, particular focus HS. The results indicate dietary modifications hold promise therapeutic intervention mitigate burden Microbiota analyses identification key are crucial for deeper understanding these conditions. Future research is needed more thoroughly delineate causal versus associative roles both

Language: Английский

Citations

1
Hidradenitis suppurativa pathogenesis: Extrinsic factors DOI
Valdemar Wendelboe Nielsen, Simon Francis Thomsen, Haley B. Naik

et al.

Journal of the American Academy of Dermatology, Journal Year: 2024, Volume and Issue: 91(6), P. S17 - S21

Published: Dec. 1, 2024

Language: Английский

Citations

1
Insights into Gut Microbiome Composition in Hidradenitis Suppurativa: A Comprehensive Examination of Dietary Habits and Environmental Influences DOI Open Access
Edyta Lelonek, Jacek C. Szepietowski

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1776 - 1776

Published: June 5, 2024

This study explores the relationship between dietary habits, environmental influences, and gut microbiome composition in individuals with hidradenitis suppurativa (HS), a chronic inflammatory skin condition. A cohort of 80 participants, equally divided into HS patients healthy controls, was assessed through comprehensive questionnaires capturing demographics, other health-related information. Fecal samples were collected analyzed using next-generation sequencing to examine composition. Despite previous studies suggesting dysbiosis HS, this research found no significant differences alpha-diversity Shannon diversity index groups. However, disparities habits observed, showing higher sugar milk consumption. The also identified correlation coffee consumption presence certain bacterial genera. While did not reveal major diversity, findings on specific components suggest potential targets for therapeutic intervention. These results underscore importance further gut–skin axis its role aiming enhance management strategies modifications lifestyle interventions.

Language: Английский

Citations

0
Roles of skin microbiota in hidradenitis suppurativa: insights from a two-sample Mendelian randomization analysis DOI Creative Commons
Chenyang Yu, Yan Wei, Huidi Shucheng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with unique lesional dysbiotic features. However, the role of microbiology in pathogenesis HS remains dispute. We aimed to conduct two-sample Mendelian randomization study investigate relationship between microbiota and HS. A was performed using summary statistics from GWAS data European descent two cross-sectional, population-based German cohorts, KORA FF4 (n = 324) PopGen 273). The hidradenitis were obtained FinnGen DF10 (1,070 cases 394,105 controls). Inverse variance weighted (IVW), MR-Egger regression, median, simple mode, MRPRESSO used examine causal association suppurativa. Cochran’s Q quantify heterogeneity instrumental variables. Our suggested that genus Corynebacterium dry significantly after false discovery rate (FDR) correction (odds ratio (OR) 1.04, 95% confidence interval (CI): 1.02–1.06, P 0.0002, FDR adjusted 0.035). Additionally, we found Micrococcus moist (OR 1.10, CI: 1.03–1.18, 0.0060, 0.360), species Streptococcus salivarius 1.03, 1.01–1.05, 0.0070, Propionibacterium granulosum 1.02, 1.00–1.04, 0.0460, 0.970) are potentially before adjustment. No evidence effect reverse direction for on microbial This causally Further studies needed clarify protective probiotics

Language: Английский

Citations

0