The Influence of Microorganisms on the Onset and Development of Colorectal Cancer in Humans: A Descriptive Cross-Reference Study DOI Creative Commons
Dragan Nikolić, Stojan Latinčić,

Jelena Jevtovic

et al.

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 468 - 468

Published: March 15, 2025

Background: The aim of this study is to determine which types microorganisms influence the onset and development colorectal cancer (CRC) in humans. Methods: In patients with CRC, three swabs were taken for microbiological analysis during surgical removal cancer: first swab from surface healthy intestinal mucosa, second tumor, third middle tumor tissue. Results: mucosa colon, most prevalent microorganism was Escherichia coli at 70.5%, followed by Enterococcus spp. (47.7%) Klebsiella/Enterobacter (20.5%). Microbiological tissue showed that E. 72.7%, 40.9%, 25%, Pseudomonas aeruginosa 20%. center tissue, 77.3%, 47.7%, Klebsiella 27%, 18.2%. Conclusion: Certain bacteria can emergence cancer, while other suppress human stool samples prevent CRC.

Language: Английский

Colorectal Cancer: Epidemiology, Risk Factors, and Prevention DOI Open Access
Gholamreza Roshandel, Fatemeh Ghasemi‐Kebria, Reza Malekzadeh

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1530 - 1530

Published: April 17, 2024

Colorectal cancer (CRC) is the third most common and second cause of mortality worldwide. There are disparities in epidemiology CRC across different populations, probably due to differences exposure lifestyle environmental factors related CRC. Prevention effective method for controlling Primary prevention includes determining avoiding modifiable risk (e.g., alcohol consumption, smoking, dietary factors) as well increasing protective physical activity, aspirin). Further studies, especially randomized, controlled trials, needed clarify association between incidence or factors. Detection removal precancerous colorectal lesions also an strategy Multiple factors, both at individual community levels patient preferences, availability screening modalities, costs, benefits, adverse events), should be taken into account designing implementing programs. Health policymakers consider best decision identifying starting age selection strategies target population. This review aims present updated evidence on epidemiology,

Language: Английский

Citations

68
Revealing the association between East Asian oral microbiome and colorectal cancer through Mendelian randomization and multi-omics analysis DOI Creative Commons
Yuheng Gu, Lai Jiang,

敏之 清水

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 17, 2024

Background Colorectal cancer (CRC) poses a global health threat, with the oral microbiome increasingly implicated in its pathogenesis. This study leverages Mendelian Randomization (MR) to explore causal links between microbiota and CRC using data from China National GeneBank Biobank Japan. By integrating multi-omics approaches, we aim uncover mechanisms by which influences cellular metabolism development. Methods We analyzed profiles 2017 tongue 1915 saliva samples, GWAS for 6692 cases 27178 controls. Significant bacterial taxa were identified via MR analysis. Single-cell RNA sequencing enrichment analyses elucidated underlying pathways, drug predictions potential therapeutics. Results 19 significantly associated CRC. Protective effects observed like RUG343 Streptococcus_umgs_2425, while HOT-345_umgs_976 W5053_sp000467935_mgs_712 increased risk. revealed key including JAK-STAT signaling tyrosine metabolism. Drug prediction highlighted therapeutics Menadione Sodium Bisulfite Raloxifene. Conclusion establishes critical role of colorectal development, identifying specific microbial linked further elucidate pathways therapeutics, providing novel insights personalized treatment strategies

Language: Английский

Citations

10
Cell-death induced immune response and coagulopathy promote cachexia in Drosophila DOI Creative Commons
Ankita Singh, Yanhui Hu,

Raphael Lopes

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Tumors can exert a far-reaching influence on the body, triggering systemic responses that contribute to debilitating conditions like cancer cachexia. To characterize mechanisms underlying tumor-host interactions, we utilized BioID-based proximity labeling method identify proteins secreted by Yki act adult Drosophila gut tumors into bloodstream/hemolymph. Among major identified are coagulation and immune-responsive factors wasting phenotypes associated with tumors. The effect of innate immunity is mediated NFκB transcription Relish, dorsal, Dif, which in turn upregulate expression cachectic Pvf1, Impl2, Upd3. In addition, secrete Eiger, TNF-alpha homolog, activates JNK signaling pathway neighboring non-tumor cells, leading cell death. release damage-associated molecular patterns (DAMPs) from these dying cells presumably amplifies inflammatory response, exacerbating wasting. Targeting pathway, or production could potentially alleviate effects

Language: Английский

Citations

1
Unraveling the Role of Fusobacterium nucleatum in Colorectal Cancer: Molecular Mechanisms and Pathogenic Insights DOI Open Access

Linda Galasso,

Fabrizio Termite, Irene Mignini

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 368 - 368

Published: Jan. 23, 2025

Fusobacterium nucleatum, a gram-negative anaerobic bacterium, has emerged as significant player in colorectal cancer (CRC) pathogenesis. The bacterium causes persistent inflammatory reaction the mucosa by stimulating release of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α, creating an environment conducive to progression. F. nucleatum binds penetrates epithelial cells through adhesins such FadA, impairing cell junctions encouraging epithelial-to-mesenchymal transition (EMT), which is associated with advancement. Additionally, modulates host immune system, suppressing activity conditions favorable for tumor growth. Its interactions gut microbiome contribute dysbiosis, further influencing carcinogenic pathways. Evidence indicates that can inflict DNA damage either directly via reactive oxygen species or indirectly environment. it triggers oncogenic pathways, especially Wnt/β-catenin signaling pathway, promotes growth longevity. Moreover, alters microenvironment, impacting behavior, metastasis, therapeutic responses. purpose this review elucidate molecular mechanisms contributes CRC. Understanding these crucial development targeted therapies diagnostic strategies CRC nucleatum.

Language: Английский

Citations

1
The Influence of Microorganisms on the Onset and Development of Colorectal Cancer in Humans: A Descriptive Cross-Reference Study DOI Creative Commons
Dragan Nikolić, Stojan Latinčić,

Jelena Jevtovic

et al.

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 468 - 468

Published: March 15, 2025

Background: The aim of this study is to determine which types microorganisms influence the onset and development colorectal cancer (CRC) in humans. Methods: In patients with CRC, three swabs were taken for microbiological analysis during surgical removal cancer: first swab from surface healthy intestinal mucosa, second tumor, third middle tumor tissue. Results: mucosa colon, most prevalent microorganism was Escherichia coli at 70.5%, followed by Enterococcus spp. (47.7%) Klebsiella/Enterobacter (20.5%). Microbiological tissue showed that E. 72.7%, 40.9%, 25%, Pseudomonas aeruginosa 20%. center tissue, 77.3%, 47.7%, Klebsiella 27%, 18.2%. Conclusion: Certain bacteria can emergence cancer, while other suppress human stool samples prevent CRC.

Language: Английский

Citations

0